4: Somatosensory System Flashcards

1
Q

What are the 4 Somatosensory Sub-Modalities?

A
  • Touch (Mechanoreceptive)
  • Temperature (Thermoreceptive)
  • Pain (Nociceptive)

&&& Body Position (Proprioceptive) - motor lecture

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2
Q

What is a Dermatome?

A

-Slice/ section of the skin which has axons that enter the spinal cord at a specific spinal route

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3
Q

What are Free Nerve Endings Responsible For?

A

-Temperature & pain reception

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4
Q

What are Meissner Corpuscles Responsible For?

A
  • Detects low freq vic: 2-50Hz
  • Small receptive fields, rapid adaptation
  • Communicants w axon in unknown way
  • Specialized cell outside of the axon
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5
Q

What are Merkel Cells Responsible For?

A
  • Merkel cell = neurite complex
  • Detect static pressure ie. fine spatial discrimination (like brail).. feel gap b/w things
  • Spatial tactile perception/ aqcuity: sensitivity to force of touch
  • Small receptive field, slow adaptation
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6
Q

What are Ruffini Endings Responsible For?

A
  • Skin stretch sensation

- Large receptive fields, slow adaptation

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7
Q

What are Pacinian Corpusles Responsible For?

A
  • Detect high-freq vibrations: 100-200Hz
  • Large receptive field
  • Rapid adaptation
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8
Q

Why do we feel Second Pain?

A

-B/c of the difference in conduction times; when you touch something hot, you’ll first notice that you feel you’re touching something (A-beta), then you’ll feel first pain (A-delta) which will make you withdraw your hand & experience relief.. soon after, second pain will occur & this is when C-fibre axons reach your brain

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9
Q

Explain an Axons Route through the DCML.

A
  • Comes in
  • Ascends ipsolaterally
  • Reaches caudal medulla & synapses
  • 2nd order neuron in mechanosensory pathway receives gluta from neuron
  • -Its axon decussates & ascends to thalamus
  • VPL gets info from somatosensory system
  • -Sends info to cortex
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10
Q

What Happens to a Subject Experiencing Brown-Sequard Syndrome?

A
  • Ipsilateral loss of light touch (touch is always ipsilateral = DCML = A-beta)
  • Contralateral loss of pain & temp (STT)
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11
Q

Explain Mechano-transduction.

A

Mechano-transduction = force that’s turned into an elec signal

Na Channels

  • Produced in cell bod & ganglion & located there
  • Cell memb contains stretch gated ion channels
  • -Open in response to pressure on the cell; the cell is pressed & the membrane stretches, ion channels open b/c of the stretched memb
  • Channels are open & Na goes down its conc grad & cell starts to depol
    • force applied to cell = graded potential = membrane is stretched & more chans will go into the open state
  • -Channels do not get wider, more just open

Weak Stimulus
-May not reach threshold, cell would stretch, ion chans would open, Na would rush in, cell = depol, charge = more but cell may not reach threshold therefore no AP w/o being over threshold

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12
Q

What is a Property of Receptive Fields?

A

-Stimuli touch closer to center will cause +AP to fire than those on periphery

  • If you have two touches that occur simultaneously w/in receptive field, it can be difficult for the brain to understand this
  • -Could mistake two touches for one
  • –^Problem is solved through receptive field overlap
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13
Q

What is the Purpose of a Caliper?

A
  • Piece of metal you can spread (like tweezers) & use to ensure that both pieces will touch your skin @ the same time
  • Helps recognize the two-point discrimination threshold by body region
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14
Q

What are the Benefits of Adaptation?

A
  1. Ignore constant, innocuous stimuli to reduce distraction
  2. Avoid saturation of neuronal firing rates, allowing detection of change in stimuli intensity over a larger range of intensities
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15
Q

What is the Cost of Adaptation?

A
  • Poor judgment of absolute stimulus intensity
  • -Eliminates one-to-one mapping from stimulus intensity to firing rate

However, evolution has selected for adaptation as highly advantageous

  • Benefit is worth the cost
  • If force changes, this will affect your survival
  • -More important to detect change than the exact value of a stim
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16
Q

Explain the 4 Areas of the Primary Somatic Sensory Cortex

A

3a: proprioception
3b: light touch, small RFs - meisner & merkel
1: light touch, large RFs - ruffini & pacinian
2: light touch & proprioception

17
Q

What is a Homunculi?

A
  • Where you can map bod surface onto brain
  • Areas most sensitive have greatest density of receptors
  • # of neurons in homunculus = proportional to relevance in the body
18
Q

What is the Ratunculus?

A
  • A rat homunculus!
  • Rats = nocturnal & don’t see well- rely on whiskers & touch
  • Barrels respond to particular whiskers
  • -Damaged whisker = won’t see cluster of barrels
19
Q

What is Use-Dependent Somatosensory Plasticity?

A
  • The more you use something, the bigger its representation in the homunculus
  • Homunculus changes shape; neurons in brain are taken over by new inputs & change shape
20
Q

What is Deafferentation Plasticity?

A

-Lose a limb & adjacent parts in the homunculus will fill themselves in

21
Q

Explain an axons route through the STT.

A
  • Comes in
  • Axons synapse in spinal cord
  • Second order neurons decussate
  • Synapse in VPL thal & go to layer IV of cortex
22
Q

What is the Function of a Thermoreceptor?

A
  • Respond to temp
  • Have ion chans that open in response to partic stim
  • Cold receptors & warm receptors
  • -Both adapt & respond to change
  • –We experience certain illusions b/c of this
23
Q

Explain the Cold/ Warm Water Temperature Illusion.

A
  • Cold or warm receptors have adapted in their preferred water
  • -Won’t fire as much in lukewarm water

Ie. Warm receptors wont fire as much as cold receptors in lukewarm water in the warm hand
-This is b/c the warm hand has adapted, the receptors are in a state of fatigue- cold receptors are firin more than your warm receptors, so your hand must be cold

  • Brain makes unconscious inferences all the time *
24
Q

Why do Chile Pepper Taste so Hot?

A
  • Capsaicin! –> activates warm receptors
  • -Ion channel on warm receptor, VR1 receptor, opens (heat-gated) chan & Na will come in when they’re open
  • – + temp = + open
  • Capsaicin = lipophilic & will diffuse across the membrane of a free-nerve membrane & hit its binding site: don’t know why binding site exists
  • -Brain makes an inference b/c it’s activated
  • -Unconscious perception of warmth
  • –Some are hotter than others b/c there is more capsaicin
  • -Pathways = in white matter
25
Q

Explain Referred Pain.

A

Lots of organ problems can be felt in diff parts of the body, why? Ie. heart attack & left arm

Convergence!

  • Two axons synapse on the same 2nd order neuron
  • Brain isn’t used to synapse from organ as much as it is from other area & infers that the pain/ excitation is from the other area (usually organ)

Caused by convergence of visceral & cutaneous (skin) afferents onto a single dorsal horn projection neuron

26
Q

Explain the Gate Hypothesis.

A
  • Fall & scrape your knee- lots of APs in nociceptors
  • -They release gluta onto the STT
  • -Neurons decussate & go to other side
  • -You feel lots of pain

-You rub the injured area & cause APs in mechanoreceptors (ie. A-beta) to fire

  • A-beta projects ipsolaterally
  • -Has a collateral!
  • AP reaches branch point & goes in both directions
  • The one that goes down will release gluta onto an inhib local circuit interneuron (another small GABAergic neuron that has a gluta receptor & is inhibited) - will release GABA onto same STT pathway
  • STT neuron receives gluta from nociceptors & GABA from interneuron/ mechanoreceptors
  • -Gluta lets in Na & produces EPSP
  • -GABA lets chloride in & produces IPSP
  • IPSPs & EPSPs counteract w each other

Called “Gate Theory” b/c you can gate pain on/ off

27
Q

Explain Descending Pain Control Pathways.

A

Your brain can reduce pain depending on its mental state!

  • Amygdala indirectly (through midB) projects axons down to the spinal cord
  • Raphe Nuclei
  • -Indirectly activated by amygdala & descends
  • -Syn on axon terminal of enkephalin-containing local circuit neuron
  • –Axoaxonic syn from interN to c-fiber
  • —Opens up K chans (inc in K conductance)
  • —Closes VGCa chans (harder to open now)
  • —Prevents Ca from coming in & = harder to synapse
  • —–Reduces pain message!

Placebo: your brain is causing enkephalin to be released

28
Q

Explain Phantom Limb.

A
  • Neurons in homunculus randomly start to fire lots of APs; you feel pain in a limb you lost
  • Is an illusion