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M- Pathology > 4 Smith > Flashcards

4 Smith Flashcards

1
Q

Virus size

A

20-1000nm

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2
Q

Virus structure

A

Virion
Nucleic acid (genome)
Protein shell (capsid)
Phospholipid membrane surrounding capsid (envelope)

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3
Q

Virus capsids are composed of

A

repeating protein subunits (capsomers) arranged in helical or icosahedral symmetry

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4
Q

Nucleocapsid

A

capsid + genome

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5
Q

Positive strand RNA genome is when…

A

mRNA sense is translated into viral proteins

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6
Q

Negative strand RNA genome is when…

A

Genome is complementary to mRNA. The mRNA is obtained by transcribing the virus genome as a template

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7
Q

Monopartite

A

Genome is a single nucleic acid molecule

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8
Q

Segmented virus

A

Genome contains several nucleic acid molecules

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9
Q

Viral genome size

A

3-1200kb

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10
Q

Virus classification

A 
Viridae (families)
Virinae (subfamilies)
Genera
Species
Strains
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11
Q

What are arboviruses?

A

Transmitted by biting insects

Arthropod borne viruses

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12
Q

Examples of viruses with double stranded DNA genome

A

Papovaviridae (papillomavirus)
Adenoviridae (Adenovirus)
Herpesviridae (HSV, VZV, EBV)
Poxviridae (Variola, Myxoma, Orf)

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13
Q

Examples of viruses with single stranded DNA genome

A

Parvovirus

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14
Q

Examples of viruses with Double stranded RNA genome

A

Reoviridae (Blue tongue, Rotaviruses)

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15
Q

Examples of viruses with positive single stranded RNA genome

A

Picornaviridae (Polio, Hep A, FMDV)
Calciviridae (Norovirus)
Rubella, Hep C, Swine fever, SARS

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16
Q

Examples of viruses with negative single stranded RNA genome

A

Influenza, Measles, CDV, Mumps, Rabies

17
Q

Examples of viruses with positive single stranded RNA genome with DNA intermediate

A

Retroviridae (HIV)

18
Q

Examples of viruses with double stranded DNA genome with RNA intermediate

A

Hepadaviridae (Hep B)

19
Q

Measurement of viruses

A

EM - quantification of particles
PCR - sensitive, quantification of particles
Plaque assay

20
Q

Plaque assay

A

Dilution series of virus
Add susceptible cells
Cells destroyed by virus = plaque
Each plaque derives from one infectious virus particle

21
Q

Three phases of virus replication

A

Adsorption and penetration
Eclipse phase
Assembly and release

22
Q

Latent period

A

Time taken to make new particles

23
Q

Mean burst size

A

Av no. of virus particles per cell

24
Q

Virus - neutralising antibodies

A

Antibodies against receptor binding proteins inactivate the virus

25
Q

Eclipse phase

A

No virus particles present

M- Pathology (7 decks)

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