4🅱️ // miller workshop Flashcards
antibodies can act as what
antibodies can act as drugse
xamples of antibodies that act as drugs
Humira antibody
what does the Humira antibody do
binds to cytokine TNF-a to inhibit inflammation that would otherwise cause autoimmune diseases
why do TNF-a s need to be inhibited
they cause inflammation which can lead to autoimmune diseases
what is an antibody drug conjugate
when an antibody is raised to target a specific cell (tumour)
the antibody normally has a side chain with a linker and a warhead that is cytotoxic
positive of conjugated antibody drug conjugates
theyre very effective with little side effects
very specific ,, well targetted
whats a negative of antibody drug conjugates
theyre very expensive
dna to m rna
Transcription
what happens after dna is transcribed into mrna
exits the nuc
associates with ribosome
is translated into a protein using trna (has an aa associated with it)
recombinant dna technology
allows us to make proteins from dna artificially
why can antibodies not be administered orally
they are made up of amino acids,, enzymes such as protease will hydrolyse them,,, they will no longer be effective.
antibodies are proteins
parts of an antibody
heavy chain
light chain
constant portion // region
variable region // portion
disulphide bonds between heavy and light chain
part of the antibody that binds to the cell
variable region
whats special about the constant region
evryone has the same constant region
polyclonal
when body releases a bunch of b cells which all produce different antibodies