4 Lymphoma Flashcards
Which lymphomas are childhood lymphomas?
Burkitt, Hodgkin. (the named ones)
90% of all lymphoma/leukemia are what type?
Mature B cell type. (ones with “chronic” in the name)
Name the lympoma association: EBV
Burkitt, Hodgkin
Name the lympoma association: HTLV-1
T cell lympoma
Name the lympoma association: HHV-8
primary effusion lymphoma, Kaposi
Name the lympoma association: H. Pylori
MALT lymphoma
Name the lympoma association: B. Burdorferi?
cutaneious marginal zone lymphoma
When should you biopsy a node?
Large, lasts over a month, keeps getting bigger.
CLL can become what kind of lymphoma?
small lymphocytic lymphoma
Which is the most common lymphoma?
Large B (2nd is follicular)
Follicular lymphoma is slow or fast onset?
Slow and hard to detect! Think ADULTS!
Follicular lymphoma histo & immunohisto looks like?
- follicles w/o polarization or tingible body macrophages
- CD20, Bcl-2, CD10 [esp Bcl-2!!]
name the Bcl-2 gene rearrangement
T 14:18
Diffuse large B cell lymphoma would present clinically as?
rapidly enlarging node or mass.
Diffuse large B cell lymphoma histo & immunohisto?
- Large cells, starry sky (due to lots of apoptosis)
- CD19, 20 (same as a normal B cell)
Diffuse large B cell lymphoma has what genetic changes?
- somatic IgV heavy chain
- t 14:18 of Bcl-2
Better prognosis Large B lymphoma is which type?
germinal center type, which is negative for MUM1 (unlike activated B cell type)
Tx for B Large B lymphoma?
rituximab (anti-CD20) (watch for tumor lysis syndrome)
Jaw/orbit mass lymphoma?
Burkitt lymphoma endemic type (kids)
abdominal mass lymphoma?
Burkitt sporadic type (kids)
Burkitt lymphoma doubles how quickly? What is its immunohisto marker? Genetic change?
Mantle cell lymphoma has what immunohisto? genetics?
- CD 5
- t11:14
Mantle cell lymphoma has what immunohisto? genetics?
- CD 5
- t11:14 affecting cyclin D1
Mantle cell lymphoma prognosis?
Excellent
Marginal zone lymphoma is slow of fast-progressing?
SLOW
Marginal zone lymphoma key example is? immunohisto?
- H. Pylori MALT lymphomas!
- CD 19 & 20 (like all B cells)
Marginal zone lymphoma histo?
-scattered large cells!!!
Hodgkin lymphoma:what main 2 types exist?
Classic & nodular lymphocyte predominant.
Should you tx a single node Hodgkin with chemo?
No, excise. Chemo causes recurrence.
Hodgkin immunohisto? Presentation?
- CD15, CD30 (they are germinal center cells)
- big node, or mediastinal mass. Sometimes constitutional symptoms. Bimodal ages affected.
Hodgkin histo?
- inflammatory background
- sclerosis if “nodular sclerosing” type.
CLL (or SLL: small lymphocytic leukemia when hematogenous involvement) has what histo?
- small lymphocytes, clumped chromatin. “snickerdoodle”
- Pale “prolymphocytes”
CLL can transform to SLL or to?
Diffuse Large B
CLL immunohisto? prognosis?
- CD5, CD23.
- Great!
As a rule, low or high grade lymphomas are curable?
HIGH grade!
[high grade affect all ages, while low grade affect elderly]