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Pathology II Exam 3 > 3-Lymphomas > Flashcards

3-Lymphomas Flashcards

1
Q

What is the order of chain rearrangements in a maturing lymphoid cell?

A

Heavy (V -> D ->J ) then light (V -> J)

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2
Q

What are the CD’s on a B precursor before heavy chain rearrangement?

A

CD19, 34. (19 stays always, even when mature)

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3
Q

What are the CD’s on a B precursor after heavy chain rearrangement?

A

CD10 (and still 19)

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4
Q

What are the CD’s on a pre-B cell? Which chain rearrangements have taken place at this stage?

A
  • CD20 (and still 10 and 19)

- both heavy and light chain rearrangements

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5
Q

Mature T cells (2 types) display what CD’s?

A
  • Cytotoxic: CD 8, 3 (3 is a marker for all T cells)

- Helper: CD 4, 3

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6
Q

So, what markers does a mature B cell have?

A

Same as “pre-B” cell!
CD 20, (from final stage)
10, (only if in an active germinal center)
19 (from early precursor stage)

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7
Q

Now let’s think of it the other direction….

A

:)

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8
Q

What cells display CD 19?

A

precursor B & mature B

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9
Q

So all in all, what CD’s are on B precursors?

A

19, 34, then 10.

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10
Q

What cells display CD 20?

A

mature B

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11
Q

What cells display CD 10?

A

precursor & germinal center cells

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12
Q

What cells display CD 3?

A

All T

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13
Q

What cells display CD 4?

A

cortical thymocytes & Helper T

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14
Q

What cells display CD 8?

A

cortical thymocytes & cytotoxic T

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15
Q

What cells display CD 34?

A

myeloid and lymphoid precursors

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16
Q

Germinal centers of lymph node contain?

A

follicular dendritic cell meshwork (stains w/ CD21) and other cells…

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17
Q

What causes a lymph cell to become larger, and gain prominent nucleoli and more cytoplasm?

A

antigen exposure

18
Q

T/F lymphomas can originate from a tissue other than lymph nodes?

A

T

19
Q

A lymphoma lymph node looks histologically different from a REACTIVE lymph node how?

A

lymphoma has effacement of architecture

20
Q

Most important prognostic feature in a non-Hodgkin lymphoma is?

A

histologic subtype

[in Hodgkin it is stage]

21
Q

Which tissues are PRIMARY lymphoid tissues?

A

ones T or B’s mature in (thymus, marrow)

[secondary would be anything else]

22
Q

As T cells mature they move which direction in thymus?

A

toward medulla

[pos then neg selection]

23
Q

T/F the T cell receptor is expressed during T cell maturation in thymus?

A

T

24
Q

Where is MALT found?

A

Waldeyer’s ring, Peyer’s patch, and bronchus

25
Q

What do M cells do?

A

uptake antigen

26
Q

What’s in PALS? What about in white pulp?

A
  • T cells

- B cells

27
Q

What’s in cords of bilroth?

A

macrophages

28
Q

If red pulp of spleen expands, it’s due to?

A 
blood issue (congestion, leukemia etc)
[where white expansion would be lymph reaction or cancer]
29
Q

Nodular lesion in spleen =?

A

Hodkin or diffuse B lymphoma (no mets cuz no lymph afferents and all those immune cells kill blood-borne mets!)

30
Q

What does a centroblast do?

A

Matures in a germinal center to a large cleaved, then small cleaved, then centrocyte (plasma or memory cell). It moves to lighter zone as it matures.

31
Q

Follicular dendritic meshwork stains with what CD?

A

21

[same as what EBV uses to enter B cells!]

32
Q

What does a B cell do when if finds antigen?

A

-Becomes proliferating immunoblast in interfollicular area
-migrates to primary follicle, becomes a centroblast that undergoes somatic hypermutation/prolif to become plasma or memory cell (centrocyte).
[Tingible body macrophages eat the dead B’s]

33
Q

etiology of lymphadenOPATHY?

A

unkown (lymphadenitis is known pathogen)

34
Q

Asteroid bodies mean what?

A

granulomatous lymph node

35
Q

T/F reactive lymphoid hyperplasia regresses w/ antibiotics?

A

F

[and node is tender!]

36
Q

BCL-2 is important why?

A

anti-apoptotic. Find in follicular lymphoma. (BCL-6 is opposite. apoptotic)

37
Q

Many centroblasts and few centrocytes means?

A

cancer

38
Q

EBER is a stain for what?

A

EBV RNA

39
Q

Geographic necrosis of lymph node=?

A

bartonella henselae

40
Q

How do you dx toxoplasma?

A

IgM test. note proliferation of monocytoid B cells.

41
Q

How do you dx toxoplasma?

A

IgM test. note proliferation of monocytoid B cells.

Pathology II Exam 3 (13 decks)

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