4. Inflammatory Bowel Disease Flashcards
1
Q
How common is it?
A
Quite common, rising incidence
UC slightly more common than Crohn’s
2
Q
Who does it affect?
A
Peaks in 2nd-4th decades
3
Q
What causes it?
A
Chronic inflammation
Unclear - combination of genetic factors and autoimmunity
4
Q
What risk factors are there?
A
Smoking (more with Crohn’s), family history
5
Q
How does it present?
A
Abdo pain, fatigue, anorexia and diarrhoea PR bleeding (UC) Weight loss (CD)
6
Q
What signs might the patient have on examination?
A
Abdo distension, guarding, rebound tenderness on palpation (UC)
Diffuse abdo tenderness, clubbing (children), perianal disease
7
Q
Which other conditions might present similarly?
A
Anorexia, bullimia
Sarcoidosis
Diverticulitis
Colon cancer
8
Q
What treatments are there?
A
Aminosalicylates, immunosuppressants, antibiotics
Proctocolectomy (UC), surgery to close fistulas etc (Crohn’s)
9
Q
How would you investigate?
A
FBC, ESR, CRP, U+E, LFT (+ ferritin, B12, folate for CD) Stool sample Faecel calprotectin AXR, colonoscopy --Skip lesions in CD --Mucosal inflammation in UC
