4. Clinical autoimmunity Flashcards
SLE risk factors
-female
-afro Caribbean
-genetics
-sunlight, smoking
levels of dsDNA in SLE
high
levels of complement proteins in SLE
low
explain why people with SLE could appear SOB
inflammation of pleural membrane causes pleuritic chest pain so patient takes shallow breaths to try avoid pain
when is the joint pain worst with SLE? why?
mornings as cytokine levels highest, gels up joint
constitutional symptoms for lupus
fever, fatigue, wight loss, night sweats, poor appetite
how to differentiate between facial flushing and rash?
flushing would not be felt with eyes closed
SLE treatment
-lifestyle modification, sunscreen
-DMARDs: hydroxyquinolone, azathioprine
-steroids: prednisolone
severe SLE extra treatment
IV cyclophosphamide
RA risk factors
female
genetics
environment
pattern of joint pain in RA
bilateral, small joints
scans for RA
xray
USS
autoantibodies in RA
rheumatoid factor
anti CCP
anti Ro and La
antinuclear
RA treatment
DMARDs: methotrexate
steroids: prednisolone
combination therapy usually
