4. Cell Mediated Immunity Flashcards
Mature Naive T cells express what surface markers (6)
CD4 or CD 8 CD28 HLA class I TCR complex (with CD3) LFA-1 and VLA-4 adhesion molecules Chemokine receptors
Only cell that can activate naive T cells
DC
T cells enter LN through what structure?
High endothelial venules into the cortex
T cell activation (full) leads to the production of what transcription factors
NFAT
NF-KB
AP-1
CD80 (also known as _____) binds to what
B7-1/B7-2
binds CD28 of CD4+ T cells
After Ag recognition from DCs, T cells increase their adhesion through
inducing a high affinity state of integrins and clustering them
Without costimulation of with B7 (CD80) to its receptor _____, T cells will
B7:CD28
T cells will become anergic/not respond
CTLs may require costimulation by _____ when being presented Ag from DCs
CD4+ expression of cytokines
T cell cytokines (5)
IL-2 - T cell survival/prolif/diff signal
IL-4 - IgE class switching
IL-5 - activate eosinophils
IFN-gamma - activate macrophages
TGF-beta - inhibit T cell activation/diff Treg cells
effector T cells differ from naive resting T cells in their ability to
respond to their specific Ag without costimulation from CD80 to their CD28 receptor
T cell memory survival signals
IL-7
IL-15
reactivated by self MHC+ self peptide
Tregs express this molecule to bind CD28 and shut down IL-2 production
CTLA-4
CTLA-4 major function
negative regulation of immune responses; self-tolerance: binds B7-1 B7-2 receptors
PD1 major function
Negative regulation of T cells
expressed on T cells, B cells, myeloid cells
after Ag has arrived in the LN, it takes approximately how many days for effector cells to migrate to the periphery?
5 days
t cell transcription factors are activated within _____ and include _____
minutes - C-Fos
hours - C-Myc
