4 Flashcards

1
Q

Ursula presents to the GP with a neck lump. What information from the patient’s history and examination could the GP seek?

A
History
-previous infection
-previous neck lumps
-family history f any cancers
-duration
-how the lump has changed over time
-any pain 
-red flags (i.e. weight loss, night sweats, changes in voice which can imply laryngeal or pharyngeal cancer)
-age
Examination
-any other abnormal signs
-location of lump 
-palpation features
-is it mobile?
-moving on swallowing?
-sticking out your tongue?
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2
Q

Other than lymphadenopathy what are other causes of neck lumps?

A

-large thyroid gland
Dermoid cyst
-lipoma
-abscess

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3
Q

Explain the location and features of some neck lumps

A
  • Lipoma: benign fatty tissue growth, mobile, located around thyroid gland area, can wrap fingers around it
  • Thyroglossal duct cyst: over on sticking tongue out
  • Goitre: moves on swallowing, can’t get fingers around it
  • Salivary gland cancer: pain on eating, just under parotid gland
  • Lymphadenopathy: lump is hard
  • branchial-cleft cyst: fluid-filled near SCM, usually happens in kids
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4
Q

James is 40 and sustains a head injury after falling from his motorcycle. He was not wearing a helmet. He hit his head on the pavement and was knocked unconscious for up to a minute. On regaining consciousness he was alert and orientated and was able to stand up. He had a few minor grazes on his elbow. He declined the option of going to hospital and instead return home. Several hours later, his parents find him on the chair, confused and drowsy.

An intracranial haemorrhage is suspected. What type intracranial haemorrhage is most likely? What vessel is the most likely source of the bleeding?

A

Extradural and middle meningeal artery

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5
Q

Rose is 85 and was found wandering the streets disorientated and confused. She was taken to the hospital and her vital signs are BP 140/90, PR 72, RR 16, temp 36.8C, oxygen saturation on air 98%. There are no other signs on physical examination and she appears comfortable though a little agitated. CXR, blood tests and urinalysis are all normal.
What could the differential diagnosis be for a pt. Presenting with confusion? Which diagnosis is most likely in this case? What vessel is the most likely source of bleeding?

A
  • meds
  • UTI
  • any chest infections
  • hypoglycaemia
  • hypoxia
  • intracranial haemmorhage: subdural (most likely)
  • Bridging vein (most likely vessel)
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6
Q

Luther is 50 and presents with a headache. He complains of the light hurting his eyes and finds it painful when the doctor tries to flex his neck. He feels nauseous and vomited several times. He has felt generally unwell the last 3 days, with a sore throat and a fever. Vital signs show: temp. 38C, PR 100, BP 125/60, RR 18, and o2 saturation’s 100% on air.
What is the most likely cause for the patient’s clinical signs and symptoms?

A

-Meningitis

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7
Q

Arnold is 65 and goes to GP after having monocular blindness affecting the right eye. He described the visual loss like a black curtain falling over the eye, lasting 10 min before he regained normal vision. No other signs were present. GP suspects a type of transient ischaemic attack and has done a test to find a stenosis of an artery in the neck.

In which vessel is the stenosis?

A

-internal carotid artery

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8
Q

What is the cortical homunculus?

A
  • a distorted representation of how different parts of the brain represents different motor functions of the body
  • similar to a person hanging upside down from a monkey bar
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9
Q

Where in the brain will the motor fibres decussate to the opposite side?

A

-at the medullary pyramids

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10
Q

Is there contralateral cortical control of the cranial nerves? Why or why not?

A

-cranial nerves branch out before the medullar pyramids so decussation does not occur

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11
Q

What is one similarity and difference between the cranial nerves and spinal nerves?

A

S: part of the peripheral nervous system
D: relate to brainstem (except 2 which arise from forebrain), spinal nerves are from spine
-cranial nerves arise at irregular intervals from CNS while spinal nerves arise in segments

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12
Q

How many cranial nerves are there?

A

24 in total

-12 pairs

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13
Q

What structures do the cranial nerves supply? What is the exception?

A
  • supply structures of the head and neck

- except vagus nerve (CN X0 also supplies structures in thorax and abd

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14
Q

What are the different types that the axons of the cranial nerves can be?

A
  • purely special sensory: such as smell, sight, hearing, 3 CN
  • purely motor: innervation muscles, 5 CN
  • mixed sensory and motor: like spinal nerves
  • +/- autonomic (hitch-hike): only 4 CN carry autonomic
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15
Q

What is the brainstem?

A
  • Adjoins the brain to the spinal cord
  • Continuous with spinal cord caudally
  • vital role in regulation of cardio-respiratory function and maintaining consciousness
  • location of majority of cranial nerve nuclei
  • ascending sensory and descending motor fibres between brain and rest of body run through the brainstem
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16
Q

How many cranial nerve arise from each part of the brainstem and forebrain?

A
  • forebrain (extension of brain and not brainstem) 2 CNs
  • midbrain: 2 CNs
  • Pons: 4 CNs
  • medulla: 4 CNs
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17
Q

Describe the olfactory nerve (CN 1)

A

-one nose so CN 1
-arise from fibres of olfactory nerves (in roof of nasal cavity), to cribiform foramina, to olfactory bulb, to olfactory tract to temporal lobe (uncus)
-is a special sensory nerve for olfaction (sense of smell)
-paired anterior extensions of forebrain rather than a “true” cranial nerve
Clinical points
-not often tested: may just ask about difficulties/changes in sense of smell
-if you are testing formally, test one nostril at a time
-loss of sense of smell: anosmia
-commonest cause of anosmia is cold, respiratory tract infection
-head injury can also cause anosmia (secondary to shearing forces and/or basilar skull fracture)
-tumours at base of frontal lobes (within anterior cranial fossa) may involve CN 1

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18
Q

Describe the optic nerve (CN 2)

A

-2 eyes so cranial nerve 2
-is a special sensory nerve for sight
-paired anterior extension of forebrain rather than a “true” cranial nerve
-part of the visual pathway
-impulses generated by cells within retina in response to light: generates action potentials which propagate along optic nerve
-via other components of the visual pathway they reach primary visual cortex where they are perceived as vision
-arise from retinal ganglion cells (back of eye), to axons from optic nerve (originate from optic disc), then exits back of orbit via optic canal, then the fibres cross and merge at optic chiasm
Clinical points
-visual acuity tests (ex. Snellen chart which is the letters chart)
-visual fields
-pupillary light responses (to see if optic nerve is working)
-seen directly with ophthalmoscope (i.e. optic disc= point at which nerve enters the retina)
-carries extension of meninges: nerve affected when raised ICP
-swollen optic disc (papillodema)

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19
Q

What does the optic nerve do?

A

Carries sensory fibres from one eye (retina)

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20
Q

What does the optic chiasm do?

A
  • mixing of sensory fires from right and left optic nerves

- continues further into brain to become optic tract

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21
Q

What is the optic tract

A

-contains sensory info from part of right eye and part of left eye

22
Q

What happens if the optic nerve, optic chiasm or optic tract is damaged?

A
  • if optic nerve is damaged, then only one eye is affected
  • if optic chiasm or optic tract is damaged, then both eyes could be affected
  • different lesions within the visual pathway give very different patterns of visual loss (Ex. Retinal detachement, optic neuritis, pituitary tumour, stroke)
  • pituitary tumours compress optic chiasm, causing bilateral visual symptoms (bitemporal hemianopia)
23
Q

Where does the optic nerve start?

A

At the opthalmic disc

24
Q

Describe the visual pathway

A
  • extends back from the retina towards the primary visual cortex found within the occipital lobe
  • there is communication from the optic tracts with brainstem (midbrain) to allow for certain visual reflexes
  • ex. Pupillary reflexes to light
25
Q

What are the two cranial nerves of the forebrain?

A
  • optic nerve (CN2)

- olfactory nerve (CN1)

26
Q

What are the two cranial nerves of the midbrain?

A
  • oculomotor (CN3)

- trochlear (CN4)

27
Q

Describe the oculomotor nerve (CN3)

A

-runs lateral in the cavernous sinus
-pupillary light reflexes from optic nerve (involuntary)
-sends out message to sphincter pupillae muscle to constrict
-arises from midbrain to cavernous sinus to superior orbital fissure
-is a motor (M and A) nerve and carries autonomic parasympathetic fibres (one of the 4)
-controls most of the muscles that move the eyeball (extra-ocular muscles)
-muscle of the eye lid (Levator Palpebrae Superioris), opens eyelid
-innervates sphincter pupillae muscle (which constricts pupil)
-autonomic fibres to pupil will move eye
CLinical points
-inspect eyelids and pupil size
-test eye movements and pupillary reflexes (ex. To light)
-pathology can cause pupillary dilation and/or double vision (diplopia)
-“down and out” position with severe ptosis (eyelid droops) since levator palpebrae superioris isnt working
Causes for injury/pathology of the nerve
-raised ICP (tumour/haemorrhage)
-aneurysm (posterior communicating artery)
-cavernous sinus thrombosis
-vascular (secondary to diabetes/hypertension: typically pupil sparing)

28
Q

Why is the oculomotor vulnerable when ICP is raised?

A
  • may get compressed between tentorium cerebelli and part of temporal lobe
  • parasympathetic fibres are located outside of the nerve so they get squished first, causing pupils to dilate
  • squashing occurs from outside to in
  • tentorium cerebelli is very close to oculomotor nerve
  • with increased ICP the uncus can squish against the tentorium cerebelli causing compression
29
Q

Describe the trochlear nerve (CN4)

A

-arises from midbrain, to cavernous sinus, to superior orbital fissure
-purely motor nerve
-innervates ONE of the muscles that move the eyeball (extra-ocular muscle) the SUPERIOR OBLIQUE
-is the only nerve that EMERGES from the DORSAL aspect of the brainstem
-has the longest intracranial route
-all other cranial nerves come from the ventral side
Clinical points
-test eye movements (test CN 3, 4, and 6 at the same time
-diplopia: double vision, muscles will shift in position because weak
-rare and often subtle (patients correct the diplopia with tilt of the head)
-congenital palsies: in children but cause is uncertain
-head injury: common cause of acquire acute CN 4 injury or RAISED ICP (from any cause, even minor ones without loss of consciousness)

30
Q

What are the four cranial nerves arising from the pons?

A
  • trigeminal (CN 5)
  • abducens (CN 6)
  • facial (CN 7)
  • vestibulocochlear (CN 8)
31
Q

Describe the trigeminal nerve (CN 5)

A

-has 3 branches that have an extensive distribution supplying skin of the face and scalp and deep structures of the face
-arise from the pons Into trigeminal ganglion
-trigeminal ganglion will split into Va, Vb, Vc
-Va goes into superior orbital fissure and then goes into the orbit
-Vb goes into foramen rotundum and then goes into pterygopalatine fossa
-Vc goes into foramen ovale and then goes into infratemporal fossa
-is a general sensory and motor nerve
-function is the main sensory nerve supplying skin of face and part of scalp
-sensory to deeper structures within head (ex. Paranasal air sinuses, nasal and oral cavity, anterior part of tongue (general sensation NOT taste), and meninges
-motor to muscles of mastication (Vc only)
Clinical Points
-test by checking sensation (to touch) in areas of its dermatomes (Va, Vb, Vc)
-test muscles of mastication (jaw jerk) and corneal reflex
-# of branches vulnerable in orbital/facial trauma and fractures
-# of conditions can involve branches of the trigeminal nerve (ex. Trigeminal neuralgia shingles)

32
Q

What is opthalmic shingles?

A
  • rep. The dermatome of the opthalmic nerve
  • can affect very front surface of the eye
  • will potentially scar eye affect vision
33
Q

What is a corneal ulcer?

A

-extremely painful because many sensory nerves

34
Q

What are the branches of the trigeminal divisions?

A

CN Va (Opthalmic division)
-frontal, lacrimal, and nasociliary (enter into the orbit through superior orbital fissure)
-frontal continues out of orbit as supraorbital and supratrochlear nerves
-branches into forehead
CN Vb (Maxillary division)
-many branches
-note infraorbital nerve and superior alveolar nerves (anterior, middle and posterior)
-superior alveolar (teeth): innervate upper teeth and gums
CN Vc (Mandibular division)
-inferior alveolar, continues as mental nerve: innervates lower teeth and gums
-auriculotemporal
-lingual

35
Q

Describe the frontal, lacrimal and nasociliary branches of the opthalmic division

A
  • many sensory branches from the eye, conjunctive, orbital contents, and structures within or deep to its dermatomal distribution
  • frontal branch exits the front of orbit as supraorbital and supratrochlear (carrying sensory info from forehead)
36
Q

Describe the branches of the maxillary division

A
  • infraorbital nerve runs through the floor of Brit
  • carries sensory from area of cheek and lower eye lid
  • is susceptible to injury in orbital floor fractures
  • lose sensation in eye bag area
  • like punching someone in the eye
  • there are a number of other branches (including the superior alveolar nerves)
  • carries sensory from deep structures of the face (nasopharynx, nasal cavity, maxillary sinus), upper teeth and gums
  • nerve blocks such as by dentists, max fax (superior alveolar nerves)
37
Q

Describe the branches of the mandibular division

A
  • inferior alveolar nerve runs through the bony canal in mandible, exiting as mental nerve (via mental foramen)
  • carries sensory from area of area mental protuberance (chin), lower lip and gum
  • susceptible to injury in mandibular fractures
  • Lingual nerve carries general sensory from the anterior part of the tongue
  • auriculotemporal carries general sensory from part of ear, temple area/lateral side of head and scalp and TMJ
38
Q

Describe the abducens nerve (CN 6)

A

-Arises from lower pons (junction between pons and medulla)
-runs upwards before being able to pass into cavernous sinus
-enters into orbit via superior orbital fissure
-purely motor nerve
-innervates one muscles that moves the eye (extra-ocular muscle): LATERAL RECTUS
Clinical points
-tested using eye movements (tests 3, 4, and 6)
-patients present with diplopia
-microvascular complication (diabetes/hypertension) can affect nerve
-susceptible to injury in raised intracranial pressure (ex. Due to bleed, tumour)

39
Q

I am not a ‘true’ cranial nerve but an extension of the central nervous system, who am I?

A

-olfactory nerve (CN 1) and optic nerve (CN 2)

40
Q

I carry an extension of the meninges and patients can report abnormalities in my function when there is raised intracranial pressure, who am i?

A

-olfactory nerve (CN 1) and optic nerve (CN 2)

41
Q

I arise from the dorsal aspect of the midbrain, who am I?

A

Trochlear nerve (CN 4)

42
Q

I am vulnerable to compression from raised intracranial pressure during my route, as i run over the medial part of the petrous bone in close proximity to the edge of the tentorium cerebelli, who am I?

A

Oculomotor nerve (CN 3))

43
Q

I only innervate one of the muscles that move the eye and I arise from the pons, who am I?

A

Abduces nerve (CN 6)

44
Q

How can we remember what muscles CN 4 and CN 6 innervate?

A

SO4 LR6: superior oblique CN 4, lateral rectus CN 6

45
Q

I am one of the branches of the trigeminal nerve but I do not pass through the lateral wall of the cavernous sinus, who am I?

A

Mandibular branch (Vc) of trigeminal nerve

46
Q

One of my distal (extracranial) branches is the buccal nerve, who am I?

A

Facial nerve (CN 7)

47
Q

I pass through the foramen ovale and into the infratemporal fossa, who am I?

A

Mandibular branch (Vc) of trigeminal nerve

48
Q

I pass through the foramen rotundum into the pterygopalatine fossa, who am I?

A

Maxillary division (Vb) of trigeminal nerve

49
Q

We each have a route through the cavernous sinus, who are we?

A

CN 3, 4, 5 (except mandibular) and 6

Oculomotor, trochlear, trigeminal, aduces

50
Q

What dense CT is found running the length of the (medial) longitudinal fissure and to what structures does this attach anteriorly and posteriorly?

A
  • structure is the falx cerebelli

- attaches anteriorly to crista galli and posteriorly to occipital ridge

51
Q

What dense CT runs between the inferior part of the occipital lobes and the cerebellum below?

A

Tentorium cerebellum

52
Q

What are ventricles in the brain?

A
  • 4 ventricles in brain
  • small cavities that contain CSF
  • the arachnoid granulation produces CSF