4-14-13 Flashcards
Young kid with high Total bilirubin and absent/very low direct bilirubin think Crigler-Najjar syndrome. Defect in what enzyme?
Glucuronyl transferase
Treatment of Crigler-Najjar type 1 and 2?
Type 1 liver transplant the only cure.
Type 2 phenobarbital to decrease hyperbilirubinemia.
Phototherapy to decrease chance of kernicterus
Name some sxs of diverticulitis
Left side Abd pain. Constipation and flatus. Fever, elevated WBC, Tachycardia and tenderness.
How Strep. pneumo protect itself?
Inactivation of complement and IGA proteases.
How Staph. aureus protect itself?
It makes protein A that binds to the Fc portion of IgG thus preventing Opsonization.
Penumocystis jiroveci causes lungs problems with neonates and HIV. Stained with? Appearance>
Methenamine silver. Roughly spherical with sharply outlined walls.
Decrease Tissue Oxygen Tension is the same thing as saying?
Tissue Hypoxia
Severed right optic nerve causes what during the light test on the right eye.
No pupillary constriction in the Rt and Lt eye.
Light on the left will cause constriction of both eyes if CN3 is intact.
Anti-GAD antibodies ( anti- glutamic acid decarboxylase) is seen in what condition?
DM type 1.
Barr bodies are seen when?
Whenever somatic cells have two XX like in normal female or any other genetic condition that causes two or more X chromosome.
Filtered Load = GFR x Plasma Concentration
.
Pseudomonas often affects pts with cystic fibrosis. What is the MOA of cell damage?
Exotoxin A = inhibits eEF2 = decreases protein synthesis.
Uncontrolled HTN can cause Aortic Dissection.
.
Benzodiazepines works on GABAa by what mechanism?
It increases the frequency of the GABAa channel opening.
Barbiturates works on GABAa by what mechanism?
It increases the duration of the GABAa channel opening.
