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3SQ1 Flashcards

1
Q

Carbon tetrachloride

a. Halogenated Aliphatic Hydrocarbons
b. Aromatic Hydrocarbons

A

a. Halogenated Aliphatic Hydrocarbons

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2
Q

Xylene

a. Halogenated Aliphatic Hydrocarbons
b. Aromatic Hydrocarbons

A

b. Aromatic Hydrocarbons

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3
Q

This is a tridentate iron chelator is used to treat iron overload caused by blood transfusion

a. Dimercaprol
b. Deferoxamine
c. Deferasirox
d. Deferiprone

A

c. Deferasirox

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4
Q

Clinically used as chelator of choice for iron poisoning

a. Dimercaprol
b. Deferoxamine
c. Deferasirox
d. Deferiprone

A

b. Deferoxamine

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5
Q

Isolan

a. Organochlorine pesticide
b. Organophosphorus pesticide
c. Carbamate pesticide
d. Botanical pesticides

A

c. Carbamate pesticide

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6
Q

Diazinon

a. Organochlorine pesticide
b. Organophosphorus pesticide
c. Carbamate pesticide
d. Botanical pesticides

A

b. Organophosphorus pesticide

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7
Q

Pyramat

a. Organochlorine pesticide
b. Organophosphorus pesticide
c. Carbamate pesticide
d. Botanical pesticides

A

c. Carbamate pesticide

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8
Q

These herbicides generate N-nitrosodimethylamine
(NDMA) which is a potent human carcinogen:

a. Chlorophenoxy
b. Glyphosate
c. Bipyridyl

A

a. Chlorophenoxy

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9
Q

This is a brownish irritant gas associated with fires and causes silo-filler’s disease:

a. Carbon monoxide
b. Sulfur dioxide
c. Nitrogen oxide
d. Ozone

A

c. Nitrogen oxide

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10
Q

“This is a colorless, tasteless, odorless and nonirritating gas byproduct of incomplete combustion”

a. Carbon monoxide
b. Sulfur dioxide
c. Nitrogen oxide
d. Ozone

A

a. Carbon monoxide

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11
Q

This combines tightly but reversibly with oxygen binding sites of hemoglobin

a. Carbon monoxide
b. Sulfur dioxide
c. Nitrogen oxide
d. Ozone

A

a. Carbon monoxide

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12
Q

Environmental pollutant used in coolant materials of
air-conditioning systems:

a. Polychlorinated biphenyls (PCBs)
b. Asbestos
c. Perfluorinated Compounds (PFCs)
d. Endocrine Disruptors

A

c. Perfluorinated Compounds (PFCs)

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13
Q

Exposure to this may come from batteries, electroplating or galvanizing:”

a. Arsenic
b. Beryllium
c. Cadmium
d. Mercury

A

c. Cadmium

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14
Q

The organic form of this heavy metal may cause encephalopathy:

a. Arsenic
b. Beryllium
c. Cadmium
d. Lead
e. Mercury

A

d. Lead

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15
Q

This confers special properties to alloys and metals

a. Arsenic
b. Beryllium
c. Cadmium
d. Lead
e. Mercury

A

b. Beryllium

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16
Q

This interferes with heme synthesis:

a. Arsenic
b. Beryllium
c. Cadmium
d. Lead
e. Mercury

A

d. Lead

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17
Q

Clinically used for treatment of radioactive cesium contamination

a. Succimer
b. Unithiol
c. Penicillamine
d. Prussian Blue

A

d. Prussian Blue

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18
Q

Major effect of organochlorine pesticides

a. Respiratory depression
b. Cholinergic stimulation
c. Hyperreactive airways
d. CNS stimulation

A

d. CNS stimulation

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19
Q

Damages the lung infrastructure that produces the surfactant

a. CO
b. Ozone
c. Hydrogen sulfide
d. NO

A

d. NO

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20
Q

True of carbamate poisoning compared to
organophosphates EXCEPT

a. Less risk of poisoning because of larger therapeutic index
b. Spontaneous reactivation of cholinesterase is more rapid
c. Pralidoxime is indicated for both to reverse its effects
d. Clinical effects are of shorter duration

A

c. Pralidoxime is indicated for both to reverse its effects

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21
Q

Concerned with the toxic effects of chemical and physical agents on populations and communities of living
organisms within defined ecosystems

a. Occupational toxicology
b. Environmental toxicology
c. Ecotoxicology
d. Industrial toxicology

A

c. Ecotoxicology

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22
Q

Least affected by halohydrocarbons

a. Liver
b. Kidneys
c. Heart
d. Lungs

A

d. Lungs

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23
Q

Second-line oral chelator for patients with transfusional iron overload due to thalassemia

a. Deferiprone
b. Deferoxamine
c. Penicillamine
d. Deferasirox

A

a. Deferiprone

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24
Q

Interacts with sulfhydryl groups, inhibiting enzymes and altering cell membranes

a. Lead
b. Arsenic
c. Mercury
d. More than 2 choices are correct

A

d. More than 2 choices are correct

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25
Q

Interference with the action of essential cations, (Ca+2,
Fe+2, & Zn+2)

a. Lead
b. Arsenic
c. Mercury
d. More than 2 choices are correct

A

a. Lead

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26
Q

Environmental pollutant used as heat transfer fluid, lubricating oil and flame retardants:

a. Perfluorinated Compounds (PFCs)
b. Polychlorinated biphenyls (PCBs)
c. Asbestos
d. Endocrine Disruptors

A

b. Polychlorinated biphenyls (PCBs)

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27
Q

Environmental pollutant used in coolant materials of air conditioning systems:

a. Perfluorinated Compounds (PFCs)
b. Polychlorinated biphenyls (PCBs)
c. Asbestos
d. Endocrine Disruptors

A

a. Perfluorinated Compounds (PFCs)

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28
Q

Genetically modified crops were developed to have resistance to this type of herbicide:

a. Chlorphenoxy
b. Glyphosate
c. Bipyridy

A

b. Glyphosate

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29
Q

These herbicides generate N-nitrosodimethylamine (NMDA) which is a potent human carcinogen

a. Chlorphenoxy
b. Glyphosate
c. Bipyridyl

A

a. Chlorphenoxy

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30
Q

Clinically used for treatment of radioactive cesium contamination

a. Succimer
b. Unithiol
c. Penicillamine
d. Prussian Blue

A

d. Prussian Blue

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31
Q

This is a bidentate iron chelator is used as a second line chelator for patients with transfusional overload
due to thalassemia

a. Dimercaprol
b. Deferoxamine
c. Deferasirox
d. Deferiprone

A

d. Deferiprone

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32
Q

This is a tridentate iron chelator is used to treat iron overload caused by blood transfusion

a. Dimercaprol
b. Deferoxamine
c. Deferasirox
d. Deferiprone

A

c. Deferasirox

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33
Q

Clinically used for copper poisoning like in Wilson’s disease

a. Edetate Calcium Disodium
b. Deferoxamine
c. Penicillamine
d. Succimer
e. Dimercaprol

A

c. Penicillamine

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34
Q

This is metabolized by methylation and eliminated majority thru the kidneys

a. Arsenic
b. Beryllium
c. Cadmium
d. Lead

A

a. Arsenic

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35
Q

This confers special properties to alloys and metals

a. Arsenic
b. Beryllium
c. Cadmium
d. Lead
e. Mercury

A

b. Beryllium

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36
Q

“Exposure to this may come from batteries, gasoline and paints:”

a. Arsenic
b. Beryllium
c. Cadmium
d. Lead
e. Mercury

A

d. Lead

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37
Q

“Exposure to this may come from batteries, electropainting or galvanizing:”

a. Arsenic
b. Beryllium
c. Cadmium
d. Lead
e. Mercury

A

c. Cadmium

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38
Q

“This is can be eliminated majority thru the kidneys, feces, sweat and breastmilk

a. Arsenic
b. Beryllium
c. Cadmium
d. Lead
e. Mercury

A

d. Lead

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39
Q

Parathion

a. Organochlorine pesticide
b. Organophosphorus pesticide
c. Carbamate pesticide
d. Botanical pesticides

A

b. Organophosphorus pesticide

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40
Q

Trichlorfon

a. Organochlorine pesticide
b. Organophosphorus pesticide
c. Carbamate pesticide
d. Botanical pesticides

A

b. Organophosphorus pesticide

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41
Q

Least concern of preventive systems in the workplace

a. Oral
b. Transdermal
c. Inhalational
d. Injection

A

a. Oral

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42
Q

Chronic exposure

a. Intense, rapid absorption
b. Detoxifying systems overwhelmed
c. Accidental discharge of chemicals
d. Repetitive handling of a chemicals

A

d. Repetitive handling of a chemicals

43
Q

Long-term effect of organophosphate poisoning secondary to its action on NTE enzyme

a. OPIDP
b. Progressive chronic axonal neurotoxicity
c. Cardiac failure
d. Progressive weakness of respiratory muscles

44
Q

True of carbamate poisoning compared to organophosphates EXCEPT

a. Less risk of poisoning because of larger therapeutic index
b. Spontaneous reactivation of cholinesterase is more rapid
c. Pralidoxime is indicated for both to reverse its effects
d. Clinical effects are of shorter duration

A

c. Pralidoxime is indicated for both to reverse its effects

45
Q

Primary route of entry of chemicals in industrial setting

a. Oral
b. Transdermal
c. Inhalational
d. Injection

A

c. Inhalational

46
Q

A colorless irritant gas generated from combustion of fossil fuels

a. Carbon monoxide
b. Sulfur dioxide
c. Nitrogen oxide
d. Ozone

A

b. Sulfur dioxide

47
Q

This has severe irritant effects on the eyes and mucous membranes.

a. Carbon monoxide
b. Sulfur dioxide
c. Nitrogen oxide
d. Ozone

A

b. Sulfur dioxide

48
Q

This is a brownish irritant gas associated with fires and causes sil-filler’s disease:

a. Carbon monoxide
b. Sulfur dioxide
c. Nitrogen oxide
d. Ozone

A

c. Nitrogen oxide

49
Q

Perchloroethylene

a. Halogenated Aliphatic Hydrocarbons
b. Aromatic Hydrocarbons

A

a. Halogenated Aliphatic Hydrocarbons

50
Q

Chloroform

a. Halogenated Aliphatic Hydrocarbons
b. Aromatic Hydrocarbons

A

a. Halogenated Aliphatic Hydrocarbons

51
Q

Parenteral chelator of choice for Iron poisoning OR Clinically used chelator of choice for iron poisoning

a. Prussian blue
b. Deferoxamine
c. Penicillamine
d. Deferasirox

A

b. Deferoxamine

52
Q

Seizures

a. Arsenic
b. Lead
c. Mercury
d. More than 2 choices are correct

53
Q

Deleterious effect of chemical pollutants to the environmental and living organisms

a. permissible exposure limit
b. Hazard
c. risk
d. ecotoxicology

A

d. ecotoxicology

54
Q

Allowable limits to chemical substance before symptoms of toxicity occurs

a. permissible exposure limit
b. Hazard
c. risk
d. ecotoxicology

A

a. permissible exposure limit

55
Q

<24 hours of exposure

a. acute
b. subacute
c. subchronic
d. chronic

A

b. subacute

56
Q

1 month of repeated exposure

a. acute
b. subacute
c. subchronic
d. chronic

A

c. subchronic

57
Q

1-3 mos of repeated exposure

a. acute
b. subacute
c. subchronic
d. chronic

A

d. chronic

58
Q

dose delivered at a single event

a. acute
b. subacute
c. subchronic
d. chronic
e. None of the above

A

e. None of the above

59
Q

colorless; tasteless; seen in generators

a. carbon monoxide
b. sulfur dioxide
c. nitrogen oxide
d. ozone
e. all of the above

A

a. carbon monoxide

60
Q

bluish, irritating gas found in burning fossil fuel

a. carbon monoxide
b. sulfur dioxide
c. nitrogen oxide
d. ozone
e. all of the above

61
Q

delayed onset pulmonary edema

a. carbon monoxide
b. sulfur dioxide
c. nitrogen oxide
d. ozone
e. all of the above

A

b. sulfur dioxide

62
Q

brownish irritant gas

a. carbon monoxide
b. sulfur dioxide
c. nitrogen oxide
d. ozone
e. all of the above

A

c. nitrogen oxide

63
Q

farmers are most susceptible to this gas due to the farm fires

a. carbon monoxide
b. sulfur dioxide
c. nitrogen oxide
d. ozone
e. all of the above

A

c. nitrogen oxide

64
Q

combining of the gas to hemoglobin

a. carbon monoxide
b. sulfur dioxide
c. nitrogen oxide
d. ozone
e. all of the above

A

a. carbon monoxide

65
Q

HH, 40/M, farmer sought consult because of multiple hyperkeratotic skin bumps on his hands and feet. You are suspecting an exposure to a chemical. You are thinking of arsenic poisoning. Classify the ff:

gastrointestinal symptoms

a. acute intoxication
b. chronic intoxication

A

a. acute intoxication

66
Q

HH, 40/M, farmer sought consult because of multiple hyperkeratotic skin bumps on his hands and feet. You are suspecting an exposure to a chemical. You are thinking of arsenic poisoning. Classify the ff:

respiratory symptoms

a. acute intoxication
b. chronic intoxication

A

a. acute intoxication

67
Q

HH, 40/M, farmer sought consult because of multiple hyperkeratotic skin bumps on his hands and feet. You are suspecting an exposure to a chemical. You are thinking of arsenic poisoning. Classify the ff:

hair and nail manifestation

a. acute intoxication
b. chronic intoxication

A

b. chronic intoxication

68
Q

as single agent in acute arsenic and inorganic mercury poisoning

a. succimer, dimercaptosuccinic acid (DMSA)
b. Edetate calcium disodium
c. Dimercaprol
d. Unithiol
e. Deferoxamine

A

c. Dimercaprol

69
Q

parenteral chelator of choice for iron intoxication

a. succimer, dimercaptosuccinic acid (DMSA)
b. Edetate calcium disodium
c. Dimercaprol
d. Unithiol
e. Deferoxamine

A

e. Deferoxamine

70
Q

water soluble chelator of lead

a. succimer, dimercaptosuccinic acid (DMSA)
b. Edetate calcium disodium
c. Dimercaprol
d. Unithiol
e. Deferoxamine

A

a. succimer, dimercaptosuccinic acid (DMSA)

71
Q

used to treat children with blood lead level concentration >45mcg/dl

a. succimer, dimercaptosuccinic acid (DMSA)
b. Edetate calcium disodium
c. Dimercaprol
d. Unithiol
e. Deferoxamine

A

a. succimer, dimercaptosuccinic acid (DMSA)

72
Q

water soluble analog of dimercaprol for arsenic and mercury intoxication

a. succimer, dimercaptosuccinic acid (DMSA)
b. Edetate calcium disodium
c. Dimercaprol
d. Unithiol
e. Deferoxamine

A

d. Unithiol

73
Q

prevents the reverse metal-induced inhibition of sulfhydryl containing enzymes

a. succimer, dimercaptosuccinic acid (DMSA)
b. Edetate calcium disodium
c. Dimercaprol
d. Unithiol
e. Deferoxamine

A

a. succimer, dimercaptosuccinic acid (DMSA)

74
Q

antidote used to a warfare agent called lewesite

a. succimer, dimercaptosuccinic acid (DMSA)
b. Edetate calcium disodium
c. Dimercaprol
d. Unithiol
e. Deferoxamine

A

c. Dimercaprol

75
Q

problem and disadvantage of this agent for acute arsenic poisoning is it redistributes the metal

a. succimer, dimercaptosuccinic acid (DMSA)
b. Edetate calcium disodium
c. Dimercaprol
d. Unithiol
e. Deferoxamine

A

c. Dimercaprol

76
Q

a chelator that protective against mercury and arsenic poisoning however has no FDA approval for any indication

a. succimer, dimercaptosuccinic acid (DMSA)
b. Edetate calcium disodium
c. Dimercaprol
d. Unithiol
e. Deferoxamine

A

d. Unithiol

77
Q

activated charcoal would not be effective for the ff, EXCEPT:

a. alcohol
b. barbiturate
c. cyanide
d. iron

A

b. barbiturate

78
Q

which of the following do not enhance the elimination of poisons?

a. activated charcoal
b. urinary retention
c. urine acidification
d. dialysis

A

b. urinary retention

79
Q

alkalinization therapy would be effective for excretion of:

a. amphetamines
b. barbiturates
c. theophylline
d. phenytoin

A

a. amphetamines

80
Q

which antidote is a competitive inhibitor at receptor site?

a. atropine
b. ethanol
c. chelating agent
d. digoxin-fab

A

a. atropine

81
Q

which neutralizing agent is used for caustic agents?

a. egg white albumin
b. starch
c. sodium bicarbonate
d. potassium permanganate

A

d. potassium permanganate

82
Q

antidote for cyanide poisoning:

a. esmolol
b. ethanol
c. fomepizole
d. hydroxocobalamin

A

b. ethanol

83
Q

dimercaprol/BAL is contraindicated in the following, EXCEPT:

a. arsenic
b. cadmium
c. copper
d. methylmercury

84
Q

used to establish safe ambient air concentrations for many chemicals found in the workplace

a. ADI
b. OSHA
c. PEL
d. TLV

85
Q

concerned with the toxic effects of chemical and physical agents on populations and communities of living organisms within defined ecosystems

a. ecotoxicology
b. environmental toxicology
c. occupational toxicology
d. industrial toxicology

A

a. ecotoxicology

86
Q

genetically modified crops were developed to have resistance to this type of herbicide:

a. bipyridyl
b. chlorphenoxy
c. glycophosate

A

c. glycophosate

87
Q

exposure to this may come form batteries, gasoline and paints:

a. beryllium
b. cadmium
c. lead
d. mercury

88
Q

damages the lung infrastructure that produces the surfactant

a. CO
b. Hydrogen sulfide
c. ozone
d. NO

89
Q

major concern with chronic exposure to benzene

a. aplastic anemia
b. CNS depression
c. GI bleeding
d. Respiratory irritation

A

a. aplastic anemia

90
Q

primary route of entry of chemicals in the industrial setting

a. oral
b. inhalational
c. transdermal
d. injection

A

b. inhalational

91
Q

inhalation of this may cause progressive pulmonary fibrosis

a. beryllium
b. cadmium
c. both
d. neither

92
Q

result of overzealous treatment of CO poisoning:

a. ARDS
b. asthma
c. perfluorinated compounds
d. polychlorinated biphenyls

A

c. perfluorinated compounds

93
Q

FDA approved oral treatment of iron overload caused by blood transfusions

a. deferiprone
b. penicillamine
c. deferoxamine
d. deferasirox

A

d. deferasirox

94
Q

this dimercapto chelating agent exhibits protective effects against the action of mercury and arsenic has reported allergic reactions including Steven-Johnson syndrome

a. succimer
b. penicillamine
c. prussian blue
d. unithiol

A

d. unithiol

95
Q

parenteral chelator of choice for iron poisoning:

a. prussian blue
b. penicillamine
c. deferoxamine
d. deferasirox

A

c. deferoxamine

96
Q

methyl chloroform

a. aromatic hydrocarbons
b. halogenated aliphatic hydrocarbons

A

b. halogenated aliphatic hydrocarbons

97
Q

toluene

a. aromatic hydrocarbons
b. halogenated aliphatic hydrocarbons

A

a. aromatic hydrocarbons

98
Q

carbofuran

a. botanical pesticides
b. carbamate pesticide
c. organochlorine pesticide
d. organophosphorus pesticide

A

b. carbamate pesticidec

99
Q

dieldrin

a. botanical pesticides
b. carbamate pesticide
c. organochlorine pesticide
d. organophosphorus pesticide

A

c. organochlorine pesticide

100
Q

malathion

a. botanical pesticides
b. carbamate pesticide
c. organochlorine pesticide
d. organophosphorus pesticide

A

d. organophosphorus pesticide

101
Q

torsades de pointes

a. arsenic
b. lead
c. mercury
d. all of the given

A

a. arsenic

102
Q

seizures

a. arsenic
b. lead
c. mercury
d. all of the given

103
Q

clinically used for chelation of lead as well as zinc and manganese

a. dimercaprol
b. edetate calcium disodium
c. succimer
d. penicillamine

A

b. edetate calcium disodium

104
Q

clinically used for copper poisoning like in Wilson’s disease

a. dimercaprol
b. edetate calcium disodium
c. succimer
d. penicillamine

A

d. penicillamine

aaa pp (5 decks)

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