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1S Q2 (mom) Flashcards

1
Q

This receptor is usually inhibited rather than activated

a. Regulatory proteins
b. Enzyme
c. Transport protein
d. Structural protein

A

b

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2
Q

The best characterized drug receptors are:

a. Regulatory protein
b. Enzyme
c. Transport protein
d. Structural protein

A

a

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3
Q

Binding with these molecules will result to no detectable changes in the function of the biologic system

a. Effector
b. Receptor
c. Inert Binding Site
d. Spare Receptor

A

c

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4
Q

Produces full maximal effect when receptors are saturated

a. Full agonist
b. Partial agonist
c. Competitive antagonist
d. Irreversible antagonist

A

a

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5
Q

Produces less than the full effect, even when it has saturated the receptors:

a. Full Agonist
b. Partial Agonist
c. Competitive Antagonist
d. Irreversible Antagonist

A

b

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6
Q

Secondary messenger that mediate most hormonal response

a. cAMP
b. Calcium
c. PIP
d. cGMP

A

a

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7
Q

The dose at which 50% of the test population exhibit unintended effects:

a. ED50
b. LD50
c. MD50
d. TD50

A

d

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8
Q

Maximal efficacy & potency are derived from this

a. Graded dose-response relationship
b. Quantal-dose response relationship
c. both
d. neither

A

a

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9
Q

Decreased sensitivity acquired as a result of exposure to the drug

a. Idiosyncratic
b. Tolerance
c. Hyporeactive
d. Hypereactive

A

b

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10
Q

Down regulation which varies the drug response is due to:

a. Variation in drug concentration
b. alteration in endogenous ligands
c. alteration in receptor
d. changes in 2nd messenger

A

c

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11
Q

measured with a graded dose-response curve but not with quantal dose response curve

a. Maximal Efficacy
b. Potency
c. Clinical sensitivity
d. Tachyphylaxis

A

a

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12
Q

Drug interaction wherein one drug enhances the effect of another by inhibiting its metabolizing enyzme

a. Additive
b. Antagonism
c. Synergistic
D. Potentiation

A

d

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13
Q

binds to the drug inhibited

a. competitive antagonist
b. irreversible antagonist
c. chemical antagonist
d. physiologic antagonist
e. None of the above

A

c

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14
Q

binds to the drug receptor

a. competitive antagonist
b. irreversible antagonist
c. chemical antagonist
d. physiologic antagonist
e. None of the above

A

a

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15
Q

binds via covalent bonds

a. competitive antagonist
b. irreversible antagonist
c. chemical antagonist
d. physiologic antagonist
e. None of the above

A

b

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16
Q

utilizes another regulatory pathway

a. competitive antagonist
b. irreversible antagonist
c. chemical antagonist
d. physiologic antagonist
e. None of the above

17
Q

receptor dimerization

a. lipid soluble drug
b. intracellular enzymatic
c. ligand-gated ion channel
d. tyrosine kinase mediated
e. g-protein mediated

18
Q

epinephrine

a. lipid soluble drug
b. intracellular enzymatic
c. ligand-gated ion channel
d. tyrosine kinase mediated
e. g-protein mediated

19
Q

insulin

a. lipid soluble drug
b. intracellular enzymatic
c. ligand-gated ion channel
d. tyrosine kinase mediated
e. g-protein mediated

20
Q

GABA

a. lipid soluble drug
b. intracellular enzymatic
c. ligand-gated ion channel
d. tyrosine kinase mediated
e. g-protein mediated

21
Q

used by neurons in synapse

a. lipid soluble drug
b. intracellular enzymatic
c. ligand-gated ion channel
d. tyrosine kinase mediated
e. g-protein mediated

22
Q

increase cGMP phosphodiesterase

a. Gt1, Gt2
b. Gi1, Gi2, Gi3
c. Golf
d. Gq
e. Gs

23
Q

increase phospholipase C

a. Gt1, Gt2
b. Gi1, Gi2, Gi3
c. Golf
d. Gq
e. Gs

24
Q

increase adenylyl cyclase

a. Gt1, Gt2
b. Gi1, Gi2, Gi3
c. Golf
d. Gq
e. Gs

25
Q

decrease adenylyl cyclase

a. Gt1, Gt2
b. Gi1, Gi2, Gi3
c. Golf
d. Gq
e. Gs

26
Q

opens cardiac K+ channels

a. Gt1, Gt2
b. Gi1, Gi2, Gi3
c. Golf
d. Gq
e. Gs

27
Q

With spare receptors:
1. Kd
2. EC50

a. 1>2
b. 1<2
c. 1=2

28
Q

Drug Affinity:
1. Kd = 10
2. Kd = 100

a. 1>2
b. 1<2
c. 1=2

29
Q

Margin of Safety:
1. Therapeutic index = 2
2. Therapeutic index = 50

a. 1>2
b. 1<2
c. 1=2

30
Q
  1. ED50
  2. Efficacy

a. increase in 1 is followed by an increase in 2
b. increase in 1 is followed by a decrease in 2
c. increase in 1 will not affect 2

31
Q
  1. TD50
  2. Drug Safety

a. increase in 1 is followed by an increase in 2
b. increase in 1 is followed by a decrease in 2
c. increase in 1 will not affect 2

32
Q
  1. Irreversible antagonist
  2. Emax

a. increase in 1 is followed by an increase in 2
b. increase in 1 is followed by a decrease in 2
c. increase in 1 will not affect 2

33
Q
  1. EC50
  2. Potency

a. increase in 1 is followed by an increase in 2
b. increase in 1 is followed by a decrease in 2
c. increase in 1 will not affect 2

34
Q

T or F:

LD50 is the median toxic dose and means that 50% of the individuals manifested the toxic effects

35
Q

T or F:

A very safe drug might be expected to have a very large toxic dose and a much larger effective dose

36
Q

T or F:

Drug interactions are expected to produce adverse effects

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