1S Flashcards
T or F:
The protonated form of a weak acid is more lipid soluble
True
T or F:
Partial agonist does not evoke as great a response as that of the full agonist.
True
Rate of diffusion:
- alveolar membrane 2. small intestines
1>2
T or F:
Weak basic drugs are excreted faster in acidic urine.
True
Increase in A will ?
A. surface area B. rate of diffusion.
increase in B
T or F:
All chemicals are toxic in some individual at some dose.
True
This was the precursor of Pharmacology:
Materia Medica
T or F:
Plant chemicals are different from industrial chemical manufactured drugs.
False
Chemicals which generally have harmful effects:
Poison
Chemicals which are not synthesized in the body:
Xenobiotics
T or F:
Facilitated diffusion employs special carrier molecules to transport the drug molecule against a concentration gradient.
False
T or F:
Quaternary amines are permanently charged thus are always water soluble.
True
Transport of Iron bound to transferrin
Endocytosis / Exocytosis
van der Waals forces are considered as:
Electrostatic
Pharmacologic Response:
- Agonist + Allosteric activator
- Agonist + Allosteric inhibitor
1>2
Drug excretion
Pharmacokinetics
Drug metabolism
Pharmacokinetics
Drug body-interaction
Pharmacokinetics & Pharmacodynamics
Chemicals that binds to a different site and decreases the agonist effect
Allosteric inhibitor
T or F:
Partial agonist evokes a great response as that of the full agonist
False
Rate of diffusion:
- small intestines 2. stomach
1>2
Substances that act on biologic systems at the chemical (molecular) level and alter their functions
Drug
Important in the choice of administration of a particular drug for a particular patient
Pharmacokinetics
T or F:
Drug molecules that are bound to plasma proteins can permeate aqueous pores
False
increase in a will?
A. pH of the medium
B. renal reabsorption of a weak base
increase in B
T or F:
High molecular weight drug have difficulty in diffusing from one compartment to
another.
True
Chemicals that binds to a different site and increases the agonist affinity
Allosteric activator
Interaction of drugs with the internal walls of receptor pockets
hydrophobic
Pharmacologic Response:
- Partial agonist
- Full agonist
1<2
T or F:
Quaternary amines are permanently charged thus are always lipid soluble.
False
T or F:
The unprotonated form of a weak acid is more lipid soluble.
False
Denotes the actions of the drug on the body
pharmacodynamics
Describes the effects of the body on drugs
Pharmacokinetics
Drug absorption
pharmacokinetics
T or F:
Drug molecules that are bound to plasma proteins can not permeate aqueous pores.
True
strong bond between permanently charged molecules.
electrostatic
T or F:
Allosteric inhibition is not overcomed by increasing the dose of agonist.
True
T or F:
Inert binding sites does not affect drug distribution
False
Body of knowledge concerned with the action of chemicals on biologic systems.
Pharmacology
Rate of diffusion:
- skin
- small intestines
1<2
Pharmacologic Response:
- Agonist + Allosteric inhibitor
- Agonist + Allosteric activator
1<2
Drug Distribution
Pharmacokinetics
Plays the major role in deciding whether that drug is appropriate therapy for a particular symptom or disease
Pharmacodynamics
T or F:
The protonated form of a weak acid is more water soluble
False
T or F:
The unprotonated form of a weak acid is more water soluble.
True
These are receptors with no discovered ligands
Orphan receptors
Chemicals that bind to a different site and increases agonist effect
Allosteric activator
Based on Fick’s law the flux would be inversely proportional to:
thickness
Rate of diffusion:
- Alveolar membrane
- Stomach
1>2
T or F:
Allosteric inhibition is can be overcomed by increasing the dose of agonist.
False
Pharmacologic Repsonse:
- Agonist + allosteric activator
- Agonist +allosteric inhibitor
1>2
Drug receptor binding which is not readily broken.
Covalent
Increase in A will?
A. thickness of membrane
B. rate of diffusion
decrease in B
T or F:
Weak basic drugs are excreted faster in acidic urine
True
T or F:
Facilitated diffusion employs special carrier molecules to transport the drug molecule down their concentration gradient.
True
T or F:
Transport of drugs that use special carriers can be saturated and inhibited
True
Substances that act on biologic systems at the chemical (molecular) level and alter their functions.
Drug
Important in the choice of administration of a particular drug for a particular patient:
Pharmacokinetics
T or F:
All substances can be toxic under certain conditions
True
Concerned with toxic effects.
Pharmacodynamics
Plays the major role in deciding whether that drug is appropriate therapy for a particular symptom or disease.
Pharmacodynamics
Determines the group in which the drug is classified.
Pharmacodynamics
T or F:
Weak acid drugs are excreted faster in alkaline urine
true
Facilitated diffusion is classified as
special carriers
T or F:
There should be artificial separation between scientific therapies and alternative complementary medicine.
false
Which of the following is the weakest electrostatic bond
van der waals force
Chemicals with exclusive harmful effects derived from biologic origin:
toxin
Rate of diffusion:
- alveolar membrane
- Stomach:
1>2
T or F:
The protonated form of a weak base is more lipid soluble.
false
T or F:
Weak basic drugs are excreted faster in alkaline urine
false
Secretion of neurotransmitter
endocytosis/exocytosis
Area of pharmacology concerned with the undesirable effects of chemicals on biologic systems
toxicology
Hydrogen bonds between the drug and its receptor are
electrostatic
increase in A will?
A. concentration difference B. rate of diffusion
increase in B
