3rd apoptosis, fat degeneration Flashcards
basis of cell injury?
living cell point of no return NECROSIS
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degeneration
The point of no return is the point where Ca2+ influx occurs, membrane integrity destroyed = enzyme leakage.
- reversible cell injury
- accumulation
what happens during the point of no return?
- Calcium influx occur
- membrane integrity is dissolved
- enzyme leakage occurs
3 morphological changes of cell injury?
- cellular swelling / hydropic degeneration
- parenchymel degeneration
- fatty degeneration/accumulation
cellular swelling / hydropic degeneration appearance/cause?
ATP insufficiency and Na pump is not working and the cell takes up water. the cell becomes bigger. the organ is pale.
increased cytoplasm and vacular appearance of the organelles.
-increase in size do to water uptake
-pale appearance of the organ
parenchymel degeneration description.
Characteristic for the toxic affects on parenchymal organs.
characteristic fats of parenchymal organs like the liver and kidney. In microscopy the cell is very similar to hydropic degeneration do to the dilated mitochondria is the characteristic of the cell
-its MACROscopic appearance is like boiled meat: gray and fragile.
fatty degeneration / fat accumulation description?
characteristic of parenchymal organs also (liver and kidney and muscle) those cells of organs that have high lipid metabolism.
define parenchymal vs stroma?
The parenchyma is the functional parts of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, namely, the connective tissues.
fatty acid transport process?
FA = fatty acids
TAG = triacylgrlycerol
- free FA taken up from circulation by liver,
- goes through esterification forming TAG.
- apoprotein is added forming lipoproteins.
- lipoproteins are released to the circulation
-catabolism of FA by the liver forms cholesterin used up for cell membranes. ketone bodies via oxidation are also formed from FA.
where can the process of fatty acid transport be targeted resulting problems?
-obesity/starvation, overloading FA accumulation in liver.
- diabetic patients (glucose resistance) glucose cannot be taken up so the body mobilizes fatty acids instead.
- During oxygen deprivation the whole catabolism is blocked
- alcohol consumption blocked catabolism of FA.
alcohol and malnutrition may block apoprotein adding and lipoprotein synthesis.
CELL ACCUMULATES FAT do to the liver being overloaded by fat or is inhibited from metabolizing fat.
Morphological changes during cell fat accumulation?
cytoplasm fat accumulation, cell nuclei is pushed to the side and the fat accumulation my cause rupture of the cell.
Macroscopy: the organ is yellow colored
microscopy: the cell has a large clear cytoplasm do to the dissolved fat.
causes of fat degeneration/accumulation?
- toxic effect
- protein malnutrition
- diabetes
- obesity
- anoxia
types of fat accumulation?
A. diffuse fat accumulation (occurs in toxic effect)
B. mottled (spotty) (related to anoxia)
Diseases of fat accumulation?
- Steatosis hepatis diffuse
- steatosis diffuse myocardia
Steatosis hepatic diffuse definition?
Diffuse steatosis of liver, the whole liver is enlarged, diffusely colored yellow, caused by alcohol before the cytosis there is steatosis.
steatosis definition?
infiltration of liver cells with fat, associated with disturbance of the metabolism by, for example, alcoholism, malnutrition, pregnancy, or drug therapy.