394 - 395 - Leukemias Flashcards
What populations are most often affected by ALL?
Age < 15 years, Down syndrome patients
How does T-cell ALL present?
mediastinal mass (leukemic infiltration of the thymus)
What are the blood smear and bone marrow findings in ALL?
↑ lymphoblasts
What serum markers are present in ALL?
- TdT+ (marker of pre-T and pre-B cells)
2. CD10+ (pre-B cells only)
How responsive is ALL to therapy?
It is the most responsive leukemia to therapy
What are some places especially at risk for ALL spread?
CNS and testes
What translocation in ALL is associated with a better prognosis?
t(12, 21)
What lymphoma is considered the counterpart to CLL?
small lymphocytic lymphoma (SLL)
What is the difference b/w SLL and CLL?
CLL has ↑ peripheral blood lymphocytosis or bone marrow involvement
What is the normal age range for CLL patients?
> 60 years
What markers indicate CLL?
CD20+, CD5+
IS CLL of T or B cell origin?
B cell
What is the presentation and course of CLL?
Often asymptomatic, progresses slowly
What is found in the peripheral blood smear in CLL?
smudge cells
What condition involving RBCs is associated with CLL?
autoimmune hemolytic anemia