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Alex's FA - Heme/Onc > 392 - Non-Hodgkin Lymphoma > Flashcards

392 - Non-Hodgkin Lymphoma Flashcards

1
Q

What demographic group does Burkitt lymphoma occur in?

A

Adolescents or young adults

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2
Q

What are the genetics of Burkitt lymphoma?

A

t(8;14) translocation of c-myc (8) and heavy-chain Ig (14)

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3
Q

What genes are on chromosome 8 and 14 that relate to non-hodgkin lymphomas?

A

translocation of c-myc (8) and heavy-chain Ig (14)

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4
Q

Which 2 NHL’s have t(14,18)?

A

DLBCL, follicular lymphomas

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5
Q

What are the 4 non-hodgkin neoplasms of mature B-cells?

A
  1. Burkitt
  2. DLBCL
  3. mantle cell
  4. follicular lymphomas
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6
Q

What are the 2 non-hodgkin neoplasms of mature T cells?

A
  1. Adult T-cell lymphoma

2. Mycosis fungoides/ Sézary syndrome

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7
Q

How does Burkitt lymphoma appear histologically?

A

Starry sky appearance, sheets of lymphocytes with interspersed macrophages

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8
Q

What two forms of Burkitt lymphoma are there?

A
  1. Endemic form in Africa - jaw lesion

2. Sporadic form - pelvis or abdomen lesion

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9
Q

What populations does DLBCL affect?

A

Usually older adults, but 20% in children

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10
Q

What is the genetic abnormality that → DLBCL?

A

t(14,18)

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11
Q

What is the most common type of non-Hodgkin lymphoma in adults?

A

DLBCL

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12
Q

What population does mantle cell lymphoma affect?

A

Older males

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13
Q

What is the genetic abnormality in mantle cell lymphoma?

A

t(11,14): 11 = cyclin D1 and 14 = heavy chain Ig

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14
Q

What CD marker can help identify mantle cell lymphoma?

A

CD5+

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15
Q

What population is affected by follicular lymphoma?

A

adults

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16
Q

Genetic abn in follicular lymphoma?

A

t(14,18) - translocation of heavy-chain Ig (14) and bcl-2 (18)

17
Q

What chromosome is heavy chain Ig on?

A

14

18
Q

What chromosome is bcl-2 on?

A

18

19
Q

What is the function of bcl-2?

A

inhibits apoptosis

20
Q

How does follicular lymphoma present?

A

Painless “waxing and waning” lymphadenopathy

21
Q

What causes adult T-cell lymphoma?

A

HTLV-1 (a

22
Q

What risk factor is associated with HTLV-1 transmission?

A

IV drug abuse

23
Q

How does Adult T-cell lymphoma present?

A
  1. Cutaneous lesions
  2. lytic bone lesions
  3. hypercalcemia
24
Q

Which populations are particularly susceptible to Adult T-cell lymphoma?

A

Populations in:
Japan
West Africa
Caribbean

25
Q

How does mycosis fungoides/Sezary syndrome present?

A

Adults present with cutaneous patches, plaques/tumors with potential to spread to lymph nodes and viscera

26
Q

Which CD marker is present in mycosis fungoides/Sezary syndrome?

A

CD4+

Alex's FA - Heme/Onc (6 decks)

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