392 - Non-Hodgkin Lymphoma Flashcards
What demographic group does Burkitt lymphoma occur in?
Adolescents or young adults
What are the genetics of Burkitt lymphoma?
t(8;14) translocation of c-myc (8) and heavy-chain Ig (14)
What genes are on chromosome 8 and 14 that relate to non-hodgkin lymphomas?
translocation of c-myc (8) and heavy-chain Ig (14)
Which 2 NHL’s have t(14,18)?
DLBCL, follicular lymphomas
What are the 4 non-hodgkin neoplasms of mature B-cells?
- Burkitt
- DLBCL
- mantle cell
- follicular lymphomas
What are the 2 non-hodgkin neoplasms of mature T cells?
- Adult T-cell lymphoma
2. Mycosis fungoides/ Sézary syndrome
How does Burkitt lymphoma appear histologically?
Starry sky appearance, sheets of lymphocytes with interspersed macrophages
What two forms of Burkitt lymphoma are there?
- Endemic form in Africa - jaw lesion
2. Sporadic form - pelvis or abdomen lesion
What populations does DLBCL affect?
Usually older adults, but 20% in children
What is the genetic abnormality that → DLBCL?
t(14,18)
What is the most common type of non-Hodgkin lymphoma in adults?
DLBCL
What population does mantle cell lymphoma affect?
Older males
What is the genetic abnormality in mantle cell lymphoma?
t(11,14): 11 = cyclin D1 and 14 = heavy chain Ig
What CD marker can help identify mantle cell lymphoma?
CD5+
What population is affected by follicular lymphoma?
adults
Genetic abn in follicular lymphoma?
t(14,18) - translocation of heavy-chain Ig (14) and bcl-2 (18)
What chromosome is heavy chain Ig on?
14
What chromosome is bcl-2 on?
18
What is the function of bcl-2?
inhibits apoptosis
How does follicular lymphoma present?
Painless “waxing and waning” lymphadenopathy
What causes adult T-cell lymphoma?
HTLV-1 (a
What risk factor is associated with HTLV-1 transmission?
IV drug abuse
How does Adult T-cell lymphoma present?
- Cutaneous lesions
- lytic bone lesions
- hypercalcemia
Which populations are particularly susceptible to Adult T-cell lymphoma?
Populations in:
Japan
West Africa
Caribbean
How does mycosis fungoides/Sezary syndrome present?
Adults present with cutaneous patches, plaques/tumors with potential to spread to lymph nodes and viscera
Which CD marker is present in mycosis fungoides/Sezary syndrome?
CD4+
