38 (+) strand RNA viruses

Question 1

Picorna characteristics?

Answer 1

+ strand icosahedral RNA family

Question 2

T/F picorna’s have a canyon?

Answer 2

T

Question 3

How do picorna’s get ribosomes to translate their RNA?

Answer 3

VPg cap instead of 5’ cap and IRES site (internal ribosome entry site)

Question 4

picorna’s make how many polypeptides?

Answer 4

1. Then they cleave it.

Question 5

What kind of polymerase do picornas have?

Answer 5

RDRP

Question 6

Capsids are made of what subunits?

Answer 6

protein->subunit->capsomer->capsid

Question 7

Picorna’s enter body how?

Answer 7

Oral. Of picornas, only rhino’s are destroyed by acid.

Question 8

HepA causes what?

Answer 8

ACUTE hepatitis not chronic.

Question 9

How do you diagnose Hep A?

Answer 9

HepA IgM

Question 10

Name the enteroviruses and the disease they cause?

Answer 10

• Polio
• Coxsackie A (aseptic meningitis, hand-foot-mouth herpangina, febrile pharyngitis)
• Coxsackie B (endocarditis)

Question 11

Where does polio go after it enters the GI?

Answer 11

GI->blood->neurons->CNS. paralysis.

Question 12

What is the polio LIVE vaccine?

Answer 12

Sabin (not Salk)

Question 13

Flaviviruses are most like what other virus family? How are they different?

Answer 13

Picorna (but enveloped and always enter the cell by way of endosomes)

Question 14

West Nile uses what amplifying hosts and vector?

Answer 14

• Amplify bird, (dead end human & horse)

- mosquito

Question 15

Dengue & Yellow fever use what amplifying hosts and vector?

Answer 15

• human, chimp

- aedes mosquito

Question 16

T/F antibodies to dengue provide immunity?

Answer 16

F, they make the disease worse by getting it into macrophages (produces Hemorrhagic Fever/Shock Syndrome!!)

Question 17

What age group should ALL get Hep C screened?

Answer 17

Hippies (so if you were born a bit before the 70’s basically) (sex, IV drug)

Question 18

Hep C is the NUMBER ONE cause of what?

Answer 18

liver transplant

Question 19

Where does Hep C replicate?

Answer 19

hepatocytes

Question 20

What causes damage to our bodies in Hep C virus?

Answer 20

T cells destroy hepatocytes

Question 21

What is Hep C treatment?

Answer 21

Brand new polymerase inhibitor (big $, Mike needs to invest stock in this)

Question 22

What are the Toga’s and their diseases?

Answer 22

• Rubella-German measles

- Alphaviruses (EEV, WEV, Chikungunya)- encephalitis and arthritis

Question 23

What virus family are Toga’s most like? How are they different?

Answer 23

• Flavi (even follow same amplifying hosts-birds- as WNV!)

- Togas are bigger, and make more than just 1 polypeptide

Question 24

How is Rubella transmitted?

Answer 24

respiratory, intrauterine (bigger prob!)

Question 25

Congenital rubella causes?

Answer 25

deaf, blind, retardation, heart dz

Question 26

How are toga’s treated?

Answer 26

rubella has a live vaccine, that’s all.

Question 27

Corona’s are most like what virus family? How are they different?

Answer 27

• toga

- helical, enveloped

Question 28

Name the corona’s and disease they cause?

Answer 28

• SARS: alveoli damage till you can’t breathe
• MERS: similar
• 3 that cause common cold

Question 29

How are corona’s spread?

Answer 29

respiratory

Question 30

How is SARS spread?

Answer 30

Chinese bat->civet cat->human

Question 31

How is MERS spread?

Answer 31

bats->camels->humans in Saudi Arabia

Question 32

Name the calci’s and the disease they cause?

Answer 32

• Norwalk, Norwalk-like (diarrhea vomit)

- Hep E (hepatitis ACUTE ONLY)

Question 33

How are calci’s transmitted?

Answer 33

fecal-oral

Question 34

T/F calci’s can be cultured?

Answer 34

F (T as of this year by adding gut bacteria)

Question 35

Hep E is a problem in what countries?

Answer 35

developing countries

Question 36

How are calci’s treated or prevented?

Answer 36

None