38- Menarche/Puberty/Menstrual Disorders Flashcards
Menstrual cycle occurs with the maturation of what axis?
Hypothalamic – Pituitary – Ovarian Axis
________ from the hypothalamus stimulate ________ and ________ from the anterior pituitary, which stimulates ________ and ________ from the ovarian follicle.
GnRH FSH LH Estrogen Progesterone
FSH and LH are synthesized and stored in cells called _________.
Gonadotrophs
The normal ovulatory cycle can be divided into what phases?
Follicular Phase
Luteal Phase
This ovulatory cycle phase begins with the onset of menstruation and culminates in the preovulatory surge of LH.
Follicular Phase
This ovulatory cycle phase begins with the onset of the preovulatory LH surge and ends with the first day of menses.
Luteal Phase
Decreasing levels of ________ and ________ from the regressing corpus luteum of the preceding cycle initiate an increase in ________ by a negative feedback mechanism, which stimulates follicular growth and estradiol secretion for the next cycle.
Estradiol
Progesterone
FSH
Separate cellular functions occur in the ovarian follicle. LH stimulates the _______ cells to produce androgens (androstenedione and testosterone). FSH stimulates the ________ cells to convert these androgens into estrogens (E1 and E2).
Theca
Granulosa
Both the LH and FSH are significantly suppressed through the negative feedback effect of the elevated circulating ________ and _________. If conception does not occur, these levels will decline near the end of the luteal phase as a result of corpus luteal regression. ________ with then rise which initiates new follicular growth for the next cycle.
Estradiol
Progesterone
FSH
What are the 5 peptides or biogenic amines from the hypothalamus that affect the reproductive cycle?
– Gonadotropin-releasing Hormone (GnRH)
– Thyrotropin-releasing Hormone (TRH)
– Somatotropin Release Inhibiting Factor (SRIF) or Somatostatin
– Corticotropin-releasing Factor (CRF)
– Prolactin Release-Inhibiting Factor (PIF)
_________ appears to enhance the hypothalamic release of GnRH and induce the midcycle LH surge.
Estradiol
Gonadotropins have an (INHIBITORY/STIMULATORY) effect on GnRH release.
Inhibitory
During early follicular development estradiol levels are low. About 1 week before ovulation, estradiol (E2) levels begin to increase. They generally reach a maximum 1 day before the midcycle _______ peak. After this there is a marked and precipitous fall.
LH
During the luteal phase, _________ reaches a maximum 5-7 days after ovulation and returns to baseline before menstruation.
Estradiol
During follicular development, the ovary secretes only a very small amount of _________. The bulk of it comes from the peripheral conversion of the adrenal pregnenolone and pregnenolone sulfate.
Progesterone
Prior to ovulation, the unruptured luteinizing graafian follicle begins to produce increasing amounts of progesterone. Secretion of progesterone by the ________ ________ reaches a maximum 5-7 days after ovulation and returns to baseline before menstruation.
Corpus Luteum
The number of oocytes is approx. 7 million at 20 weeks gestation. Significant atresia of oogonia occurs so at birth only 1-2 million remain. At puberty with continued atresia only _________ oocytes are available for ovulation with only ________ actually ovulating.
400,000
400
After puberty, primordial follicles undergo sequential development, differentiation, and maturation until a mature graafian follicle is produced. The follicle then ruptures, releasing an ________. Subsequent luteinization of the ruptured follicle produces the ________ ________.
Ovum
Corpus Luteum
At about 8-10 weeks of fetal development, oocytes become surrounded by precursor granulosa cells. This oocyte-granulose cell complex is called a…
Primordial Follicle
In the adult ovary, a graafian follicle forms. The innermost 3-4 layers of multiplying granulosa cells become cuboidal and adherent to the ovum, this is known as the ________ ________.
Cumulus Oophorus
A fluid filled ________ forms among the granulosa cells. This enlarges and the centrally located primary oocyte migrates to the wall of the follicle. The innermost layer of the granulosa cells of the Cumulus Oophorus become elongated and form the ________ ________. This is released with the oocyte at ovulation.
Antrum
Corona Radiata
Preovulatory ______ surge initiates a sequence of biochemical and structural changes that result in ovulation.
LH
Cells on the follicular wall surface degenerate and a _______ forms. The follicular basement membrane bulges through this and when it ruptures, the oocyte is expelled into the peritoneal cavity and ovulation has occurred.
Stigma
After ovulation the granulosa cells of the ruptured follicle undergo luteinization. The luteinized granulosa cells, theca cells, capillaries, and CT form the ________ ________ which produces copious amounts of __________ and some __________.
Corpus Luteum
Progesterone
Estradiol
***Normal functional lifespan of Corpus Luteum is 9-10 days!
If pregnancy does not occur, menses ensues and the Corpus Luteum is gradually replaced by an avascular scar called _______ _______.
Corpus Albicans
Put the following steps of the ovarian cycle in order –
A. The corpus luteum progressively becomes less sensitive to basal LH and dies if levels of LH-like activity (i.e., hCG) do not increase.
B. LH surge induces meiotic maturation, ovulation, and luteinization. The corpus luteum produces high P, along with E and inhibin.
C. FSH recruits a cohort of large antral follicles to enter rapid growth phase. Follicles secrete low amounts of E and inhibin.
D. Pituitary responds to falling E and P by increasing FSH secretion.
E. High P, E, and inhibin negatively feedback on LH and FSH, returning them to basal levels.
F. Declining FSH levels progressively cause atresia of all but 1 follicle, leading to selection of dominant follicle which produces high levels of E.
G. Corpus luteum dies, E and P levels fall.
H. High E has positive feedback on gonadotropes, LH (and some FSH) surges.
I. E and inhibin negatively feedback on FSH.
1) G.
2) D.
3) C.
4) I.
5) F.
6) H.
7) B.
8) E.
9) A.
The endometrium is responsive to circulating progestins, androgens, and estrogens. It is divided into 2 zones, which are…
- Functionalis (Outer Portion)
- - Basalis (Inner Portion)
This layer of the endometrium undergoes cyclic changes in morphology during the menstrual cycle and is sloughed off at menstruation. Contains spiral arteries.
Functionalis (Outer Portion)
This layer of the endometrium remains relatively unchanged during each cycle and after menstruation provides stem cells for the renewal of the other layer. Contains basal arteries.
Basalis (Inner Portion)
The cyclic changes in histophysiology of the endometrium can be divided into 3 stages, which are…
- Menstrual Phase
- Proliferative or Estrogenic Phase
- Secretory or Progestational Phase
What endometrial phase is being described below?
– Only portion of the cycle that is visualized externally.
– Disruption and disintegration of the endometrial glands and stroma, leukocyte infiltration, and RBC extravasation.
– Sloughing of the functionalis layer and compression of the basalis layer.
Menstrual Phase
What is considered cycle day 1?
First day of menstruation
This endometrial phase is characterized by endometrial growth and proliferation secondary to estrogenic stimulation. There is an increase in length of the spiral arteries and numerous mitoses can be seen in these tissues.
Proliferative Phase
During this endometrial phase, following ovulation the secretion of progesterone by corpus luteum stimulates the glandular cells to secrete mucus, glycogen, and other substances. Glands become tortuous and lumens are dilated and filled with these substances. Stroma becomes edematous and mitosis are rare.
Secretory Phase
During the Secretory Phase, spiral arteries continue to extend into the superficial layer of the endometrium and become convoluted. At this point endometrial lining reaches its maximal _________.
Thickness
If conception does not occur by day ______ (secretory phase) the Corpus Luteum begins to regress, secretion of progesterone and estradiol declines, and the endometrium undergoes involution.
23
1 day prior to the onset of menstruation, marked constriction of the _________ arteries occurs resulting in ischemia of the endometrium, leukocytes infiltration, and RBC extravasation. The resulting necrosis causes sloughing of the endometrium resulting in menstruation.
Spiral
The _________ cycle is a terminal event of a physiologic process that enables the uterus to be prepared to receive another conceptus.
Menstrual
Intact coagulation pathway is important in regulating menstruation. Menstruation disrupts blood vessels, but with normal homeostasis the injured vessels are rapidly repaired. Restoration of blood vessels requires successful interaction of ________ and ________ ________.
Platelets
Clotting Factors
Medications such as Warfarin, Aspirin, and Clopidogrel can impair the coagulation system and be associated with…
Heavy bleeding
Initial reproductive health visit should occur between ages ________ years. Provides an opportunity to start patient-physician relationship, build trust, and counsel pt’s and parents regarding healthy behavior. Primary goal of this visit is to provide preventative health care services, including educational information and guidelines, rather than problem-focused care. A general exam, breast exam, and external exam may be indicated.
13-15
An internal exam is not routinely performed unless indicated. Recommended first Pap test is at the age of _______.
21
This vaccine is one series for those who are not previously immunized between the ages of 9-26. It offers protection against cervical cancer, cervical dysplasia, vulvar or vaginal dysplasia, and genital warts.
Human Papillomavirus Vaccine – called Gardasil
***Specifically Gardasil 9!