36/37: WBC Pathology- Fang Flashcards
lymphoma v. leukemia
lymphoid neoplasms arising as discrete masses
lymphoid or myeloid neoplasms with involvement of blood and bone marrow
CD20 =
CD3 =
B cell marker
T cell marker
B cell markers
CD 19
CD 20
Lamda light chain
most tumors are ______ in 10-20 yo
lymphoma
stage = ?
single lymph node REGIONS (not nodes!) or extralymphatic site
I
stage = ?
two or more LN REGIONS or extralymphatic site on same side of DIAPHRAGM
II
stage = ?
LN REGION or extralymphatic site on both side of the DIAPHRAGM
III
stage = ?
disseminated or diffuse involvement of one or more extralymphatic sites
IV
A v. B staging of lymphoma
a- asymptomatic
b- fever, night sweats or 10% weight loss
what b-cell lymphomas arise from the germinal center?
mantle zone?
follicular AND burkitt
mantel cell
key characteristics of follicular lymphoma
middle age
widespread disease at diagnosis
peripheral and central lymphadenopathy
splenomegaly
BM 50%
low grade v. high grade follicular lymphoma
low- mostly centrocytes
high- greater than 15 centroblasts/hpf
+ = CD 19, CD 20, CD 10, Bcl-2
- = CD5 CD3
follicular lymphoma
key characteristics mantle cell lymphoma
50-60 yo male generalized lymphadenopaty with BM and liver involvement splenomegaly 50% lymphomatoid polyposis
lymphomatoid polyposis indicates…
mantle cell lymphoma
+ = CD 19/20, CD5, Cyclin D1
- = CD23, CD3
mantle cell lymphoma
three types of burkitt lymphoma
endemic/African (4-7 yo)(EBV+)(jaws, facial bones)
Sporadic (30 yo)(abdominal, ielo-cecal)
Immunodeficiency (HIV/AIDS)(nodal, bone marrow)
*all at risk for CNS involvement
**diffuse monomorphic infiltrate of intermediate size round to slightly irregular lymphoid cells with multiple peripherally placed nucleoli
Burkitts lymphoma
“starry sky pattern” or tingible body macrophages
burkitts lymphoma
\+ = CD 10, CD19, CD 20 - = bcl-2
burkitt lymphoma
occur only in adults, CD52 involved in pathogenesis
adult t cell leukemia/lymphoma
mature t cell neoplasm caused by HTLV1
not common in US
CD4+
flower cells
adult t cell leukemia/lymphoma
CD 4+
cerebriform nuclei
mycosis/fungoides/sezary syndrome
skin is always involved
epidermal plaque phase followed by tumor phase in dermis
mycosis fungoides
leukemia and generalized exfoliative erythroderma simultaneoulsy
sezary syndrome
abrupt stormy onset likely due to mediastinal mass
Tcell ALL
sheets of monotonous blasts
Tcell ALL
CD34+
TdT+
CD1a+
cytoplasmic CD3 + (not surface CD3)
Tcell ALL
CD30+
ALK-1+
EMA+
ALCL
anaplastic large T cell lymphoma
pleiomorphic with Hallmark cells
ALCL
hallmark cells are medium sized with kidney shaped nuclei
