36/37: WBC Pathology- Fang

Question 1

lymphoma v. leukemia

Answer 1

lymphoid neoplasms arising as discrete masses

lymphoid or myeloid neoplasms with involvement of blood and bone marrow

Question 2

CD20 =

CD3 =

Answer 2

B cell marker

T cell marker

Question 3

B cell markers

Answer 3

CD 19
CD 20
Lamda light chain

Question 4

most tumors are ______ in 10-20 yo

Answer 4

lymphoma

Question 5

stage = ?

single lymph node REGIONS (not nodes!) or extralymphatic site

Answer 5

I

Question 6

stage = ?

two or more LN REGIONS or extralymphatic site on same side of DIAPHRAGM

Answer 6

II

Question 7

stage = ?

LN REGION or extralymphatic site on both side of the DIAPHRAGM

Answer 7

III

Question 8

stage = ?

disseminated or diffuse involvement of one or more extralymphatic sites

Answer 8

IV

Question 9

A v. B staging of lymphoma

Answer 9

a- asymptomatic

b- fever, night sweats or 10% weight loss

Question 10

what b-cell lymphomas arise from the germinal center?

mantle zone?

Answer 10

follicular AND burkitt

mantel cell

Question 11

key characteristics of follicular lymphoma

Answer 11

middle age
widespread disease at diagnosis

peripheral and central lymphadenopathy
splenomegaly
BM 50%

Question 12

low grade v. high grade follicular lymphoma

Answer 12

low- mostly centrocytes

high- greater than 15 centroblasts/hpf

Question 13

+ = CD 19, CD 20, CD 10, Bcl-2

• = CD5 CD3

Answer 13

follicular lymphoma

Question 14

key characteristics mantle cell lymphoma

Answer 14

50-60 yo
male
generalized lymphadenopaty with BM and liver involvement
splenomegaly 50%
lymphomatoid polyposis

Question 15

lymphomatoid polyposis indicates…

Answer 15

mantle cell lymphoma

Question 16

+ = CD 19/20, CD5, Cyclin D1

• = CD23, CD3

Answer 16

mantle cell lymphoma

Question 17

three types of burkitt lymphoma

Answer 17

endemic/African (4-7 yo)(EBV+)(jaws, facial bones)

Sporadic (30 yo)(abdominal, ielo-cecal)

Immunodeficiency (HIV/AIDS)(nodal, bone marrow)

*all at risk for CNS involvement

Question 18

**diffuse monomorphic infiltrate of intermediate size round to slightly irregular lymphoid cells with multiple peripherally placed nucleoli

Answer 18

Burkitts lymphoma

Question 19

“starry sky pattern” or tingible body macrophages

Answer 19

burkitts lymphoma

Question 20

\+ = CD 10, CD19, CD 20
- = bcl-2

Answer 20

burkitt lymphoma

Question 21

occur only in adults, CD52 involved in pathogenesis

Answer 21

adult t cell leukemia/lymphoma

mature t cell neoplasm caused by HTLV1

not common in US

Question 22

CD4+

flower cells

Answer 22

adult t cell leukemia/lymphoma

Question 23

CD 4+

cerebriform nuclei

Answer 23

mycosis/fungoides/sezary syndrome

skin is always involved

Question 24

epidermal plaque phase followed by tumor phase in dermis

Answer 24

mycosis fungoides

Question 25

leukemia and generalized exfoliative erythroderma simultaneoulsy

Answer 25

sezary syndrome

Question 26

abrupt stormy onset likely due to mediastinal mass

Answer 26

Tcell ALL

Question 27

sheets of monotonous blasts

Answer 27

Tcell ALL

Question 28

CD34+
TdT+
CD1a+
cytoplasmic CD3 + (not surface CD3)

Answer 28

Tcell ALL

Question 29

CD30+
ALK-1+
EMA+

Answer 29

ALCL

anaplastic large T cell lymphoma

Question 30

pleiomorphic with Hallmark cells

Answer 30

ALCL

hallmark cells are medium sized with kidney shaped nuclei