3.5 - Inhibition of DNA synthesis

Question 1

What kind of drugs are cipro/levo/moxifloxacin?
What kind of bacteria is it used to treat?
What are some precautions while taking it?

Answer 1

Fluoroquinolones
–> Gram -, aerobic
–> Choice drug for pneumonia, intra-abdominal infections, B. anthracis
–> Binds to Calcium, iron, magnesium, aluminum
–> Avoid during pregnancy d/t potential effect on cartilage development + can cause tendinopathies

Question 2

What are tendinopathies?

Answer 2

Injury + rupture of tendons

Question 3

What kind of bacteria is metronidazole used to treat?
What are some adverse effects?

Answer 3

Treats Gram- anaerobic bacteria
–> Intra-abdominal infections, trichomoniasis, bacteria vaginosis, aquatic protozoa, giardiasis (bever fever)

Adverse Effects
–> Metallic taste
–>Vertigo
–> Disulfiram effect

Question 4

What kind of medication if nitrofurantoin?

Answer 4

Antibiotic that effects DNA synthesis
–> Mostly used to treat UTIs