34 Spleen Flashcards
what is special about splenic and short gastric arteries
end arteries
where is splenic vein located compared to splenic artery
postern-inferior
what does the spleen do
antigen-processing center for macrophages
what is the largest producer of IgM
spleen
what is the spleen made up
85% red pulp 15% white pulp
what does red pulp do
filter for aged or damaged RBCs
what causes pitting
removal of abnormalities in RBC membrane
what are howell-jolly bodies
nuclear remnants
what are heinz bodies
hemoglobin
what is culling
removal of less deformable rbis
what does white pulp do/contain
immunologic function; contains lymphocytes and macrophages, bacterial clearance, but no preexisting antibodies
what does the white pulp remove?
poorly opsonized bacteria, particles, cell debris
where does antigen processing occur? between what cells?
white pulp. between macrophages and helper T cells
anatomy of the spleen
what is tuftsin, what does it do, where is it made
an opsonin. facilitates phagocytosis. produced in spleen
what is properdin, what does it do, where is it made
activates alternate complement pathway
produced in spleen
where does hematopoiesis occur and when?
occurs in spleen before birth and in conditions like myeloid dysplasia
what’s the spleen’s function in terms of platelets
reservoir
where are accessory spleens usually found, in what percent?
20%. found at the splenic hilum.
