324 Flashcards
What needs GTP to work? What does it use it for?
Microtubules
What subunits are microtubules made of?
Alpha and beta tubulin
What end do microtubules grow from?
+ (beta_ end.)
What is the structure of microtubules?
13 alpha-beta strands in a ring
What do lamins do? What part of cytoskeleton do they associate with?
Cell development and migration, connect with basement membrane, int. filaments
Do intermediate fils associate eith motor proteins
No
TABLE 9.1
Int filaments structure
2 helixes to make tetramer, 1 protein strand to make a dimer
Do intermediate filaments need energy molecules?
No
Microfilaments subunits
Actin
What type of adhesions do microfils have?
Focal
What motor proteins and other proteins do microfils associate with?
Myosins
Do all microfilaments face the same direction?
Yes
microfilaments- pointed end +/-
-
How do microfilaments grow?
Treadmilling, actin falling off 1 end, adding more to other end
What structure is thinnest? Is it hollow?
microfilaments, no, bc one strand
Do microfilaments need energy input? If so, what type?
Yes, ATP
How do microfilaments grow?
Both ends.
What type of cells is keratin mostly associated with?
Epithelial
What does keratin bind to nuclear envelope? Why is this important?
Desmosomes/hemidesmosomes, cell integrity
What does keratin do?
Links nucleus to cytoskeleton and plasma membrane, preserves cell integrity
What are neurofilaments associated with?
Microtubule support in axon extensions, maintaining neuronal integrity
Tetramer structure
N/C terminuses on both sides, 8 in 1 filament,units lined up. No ATP needed to make this happen
