31_32_Lung cancer therapy Flashcards
What are the three types of lung cancer therapy based on the aim?
Curative, Palliative, and Supportive.
What is ECOG in lung cancer therapy?
An evaluation of how fit the patient is to undergo chemotherapy, immunotherapy, or surgery -> the patient must be fit enough to survive the procedure.
What are the therapy possibilities for lung cancer?
- Surgery,
- chemotherapy,
- immunotherapy,
- targeted therapy
- radiation therapy.
What are the first line therapy options for SCLC stages I-III?
- 6 cycles of cisplatin/carboplatin + etoposide chemotherapy
- radiation of the chest after the 3rd cycle.
What is the first line therapy option for SCLC stage IV?
4-6 cycles of cisplatin/carboplatin + etoposide chemotherapy.
What are the second line therapy options for SCLC?
- Topotecan
- Epirubicin-cyclophosphamide-vincristine (4 cycles).
Is SCLC sensitive to chemotherapy?
Yes, but it always returns.
What is the recommended treatment for NSCLC in stages IA-IIIA?
Surgery
What is neoadjuvant chemotherapy?
Chemotherapy given before surgery to ease resectability.
What is adjuvant chemotherapy?
Chemotherapy given after surgery, typically from stage IB.
What is the recommended treatment for NSCLC in stages IIIB-IV?
Palliative chemotherapy, including targeted and immune therapy.
What is the first-line chemotherapy treatment for NSCLC?
Cisplatin/carboplatin + gemcitabine.
gem(jem) citabine (citadine) - (jem est une citadine)
What are the possible side effects of chemotherapy?
- Myelosuppression (neutropenia, anemia, thrombocytopenia),
- mucositis of the digestive tract,
- nausea, vomiting,
- alopecia,
- fatigue,
- neuropathy,
- renal impairment.
What is targeted therapy in adenocarcinomas?
Examination of mutations in adenocarcinomas to determine the appropriate targeted therapy.
What is the function of EGFR inhibitors?
To inhibit the tyrosine kinase function of the tyrosine kinase domain of the receptors.
What are the three generations of EGFR inhibitors?
- First generation - gefitinib, erlotinib;
- Second generation - afatinib;
- Third generation - osimertinib.