10. Pulmonary emergencies Flashcards
What is Adult respiratory distress syndrome (ARDS)?
It is a severe inflammatory reaction of the lungs that leads to pulmonary damage.
What are the characteristics of ARDS?
It is a syndrome of acute respiratory failure characterized by hypoxemia (type 1) and bilateral pulmonary infiltrates on chest imaging.
What are the systemic causes of ARDS?
Systemic causes of ARDS include sepsis (most common), trauma, shock, and acute pancreatitis.
What are the primary causes of lung damage that can lead to ARDS?
Primary causes of lung damage that can lead to ARDS include pneumonia, aspiration, inhaled toxins, and drowning incidents.
What is the pathophysiology of ARDS?
Tissue damage (pulmonary or extrapulmonary) leads to the release of inflammatory mediators, which causes an inflammatory reaction and migration of neutrophils into alveoli, leading to injury to alveolar capillaries and endothelial cells (diffuse alveolar damage).
What are the phases of ARDS?
The phases of ARDS include the exudative phase, hyaline membrane formation, and organizing phase.
What is the management of ARDS?
The management of ARDS includes
- supportive care such as mechanical ventilation,
- oxygen therapy, and fluid management,
- treatment of underlying cause,
- prevention through early recognition and treatment of sepsis, trauma, and other systemic causes.
What is the mechanism behind impaired gas exchange in ARDS?
Exudation of neutrophils and protein rich fluid into alveoli : formation of hyaline membranes
What are the clinical features of ARDS?
Acute dyspnea, tachypnea, tachycardia, cyanosis, and diffuse crackles.
What are the Berlin criteria for ARDS diagnosis?
- Acute onset,
- bilateral opacities on CXR or CT,
- hypoxemia with PaO2/FiO2 < 300mmHg,
- respiratory failure that cannot be fully accounted for by HF or fluid overload.
What is the treatment for ARDS?
- Oxygenation
- Lung protective ventilation (low tidal volume, low plateau pressure…)
- supportive care (fluid management, furosemide)
- Treat underlying cause
What is respiratory alkalosis?
It is a condition characterized by a decrease in carbon dioxide levels in the blood, leading to an increase in blood pH.
What is PaO2/FiO2?
It is a ratio used to assess the severity of hypoxemia in patients with respiratory failure.
What is the complete blood count used for in sepsis/pneumonia?
It is used to detect leukocytosis, which is an increase in the number of white blood cells, in patients with sepsis/pneumonia.
What is lung-protective ventilation?
It is a ventilation strategy that uses low tidal volume, low plateau pressure and PEEP > 5cmH2O to prevent alveolar distention and barotrauma.
What is PEEP?
PEEP stands for positive end-expiratory pressure and is a pressure applied at the end of expiration to keep the alveoli open.
What is pneumonia?
It is an inflammation of the distal small airways, alveoli, and the interstitium, which is associated with exudate accumulation in the alveolar space.
What is the difference between typical and atypical pneumonia?
Typical pneumonia has a sudden onset of fever and productive cough, while atypical pneumonia has a gradual onset of unproductive cough and dyspnea.
What is ventilator-associated pneumonia (VAP)?
Pneumonia occurring in patients on mechanical ventilation breathing machines in hospitals (typically in the ICU).
What are the gram-negative pathogens commonly associated with VAP?
Pseudomonas aeruginosa, Enterobacteriaceae (E.coli), Acinetobacter spp.
What are the symptoms and signs of pneumonia? (8)
- Fever,
- cough,
- sputum,
- dyspnea,
- chest pain,
- shortened sound with percussion,
- auscultation: fine crepitation (temporary), rales,
- X-ray shadow.
What laboratory tests are used to diagnose pneumonia?
- ↑ CRP,
- neutrophil granulocytes,
- ESR,
- LDH,
- GOT,
-↑ procalcitonin in severe sepsis (may increase in lung cancer), - ↓ renal function.