3.1 Gustation Olfaction Flashcards
Define flavour
Sensory experience of food and drink
What can food/drink in the mouth activate?
Both gustatory and olfactory afferents (via. diffusion of volatile oderants into the nasal cavity)
What are the different tastes (including extras)
<ul> <li>Salt, sweet, umami, sour, bitter (Many have subtypes bitter & sweet)</li> <li>Includes fat, heat (e.g., chilli)</li></ul>
What areTaste Buds (1)
Taste buds are a collection of taste receptive cells located at the papillae of the tongue (Not all papillae has taste buds). Humans have 2000-5000 taste buds
What are taste cells
<ul> <li>Taste cells are modified epithelial cells, which are made from dedicated stem cells</li> <li>Turnover every 2 weeks (So if taste cells are damaged, taste will return in 2 weeks if stem cells are not damaged)</li></ul>
Structure (2) of taste cells
<ul> <li>Apical surface <ul> <li>Taste pore for sampling solution [Exposed to saliva (whatever is in saliva can activate things within the tip of taste buds)]</li> </ul> </li> <li>Basal surface <ul> <li>Communicate with gustatory afferents</li> </ul> </li></ul>
Selectivity (2) of taste cells
“<ul> <li>There are 3 types of taste cells in a single taste bud: Each has a different sensitivity</li><li>Although 1 taste cell can respond to several stimuli, they have a preferential response to a single taste</li></ul><div><img></img><br></br></div>”
Final Output of Gustation
Final output from taste buds is processed centrally to achieve tastant selectivity
Sensory Transduction ofSimple Tastes?
Detected through ion channels
Sensory Transduction: Salt (1)
<ul> <li><ul><li>Salt detects Na+ ions and Na+ depolarises taste cells via. amiloride sensitive Na+ channels</li> </ul> </li></ul>
Sensory Transduction: Sour
<ul> <li>Sour detects H+ (intracellular acidification/pH levels)</li> <li>Organic acids (vs. inorganic acids) are more effective in lowering intercellular pH</li> <li>Increased acidity blocks K+ leak channels (depolarise)</li> <li>Also opens Na+ Channel (depolarise)</li></ul>
Sensory Transduction: Complex Tastes
Activate GPCRs, which activate intracellular pathways, ultimately leading to depolarisation of membrane through opening of channels
Sensory Transduction: Sweet
<ul> <li>Activate heterodimer G protein T1R2 and T1R3 receptors</li> <li>Receptors are coupled to phospholipase C, which: <ul> <li>Modulate K+ channels</li> <li>Release Ca2+ from intracellular Ca2+ stores</li> <li>Openings TRPM5 channels, which causes Ca2+ influx</li> </ul> </li></ul>
Sensory Transduction: Umami
<ul> <li>Activate heterodimer G protein T1R1 and T1R3 receptors <ul> <li>T1R1 and T1R3 responds to glutamate, enhanced by inosine</li> </ul> </li> <li>Receptors are coupled to phospholipase C, which: <ul> <li>Modulate K+ channels</li> <li>Release Ca2+ from intracellular Ca2+ stores</li> <li>Openings TRPM5 channels, which causes Ca2+ influx</li> </ul> </li></ul>
Sensory transduction:Bitter (2)
<ul> <li>Activates homodimer T2R receptor</li> <li>Several types:Come in genetically different forms</li></ul>