30: Drugs for Thyroid

Question 1

a hypothyroid drug besides levothyroxine that is T3 instead of T4

Answer 1

liothyronine

Question 2

what can amiodarone cause in the thyroid?**

Answer 2

Type II amiodarone-induced thryotoxicosis (it literally destroys the thyroid)

Question 3

what is amiodarone prescirbed for?

Answer 3

arrhythmias

Question 4

dose of iodine in amiodarone vs daily recommended intake

Answer 4

1. amiodarone daily dose: 7.4mg Iodine

2. daily recommended dosee: 0.15mg

Question 5

__% of pts taking amiodarone will develop thyrotoxicosis

Answer 5

3%

Question 6

type I vs type II amiodarone-induced thyrotoxicosis

Answer 6

1. Type 1: pts with underlying thyroid path (nodular goiter, Graves)
2. Type 2: amiodarone causes sub-acute thyroiditis

Question 7

thioamides MOA

Answer 7

block iodine organification

Question 8

PTU vs Methimazole MOAs

Answer 8

1. PTU: blocks T3/T4 synthesis + peripheral conversion

2. Methimazole: blocks synthesis only but 10x more potently

Question 9

enzymes that synthesizes T3/T4 in thyroid

Answer 9

thyroperoxidase

Question 10

which drug has the AEs of anaplastic anemia, liver inflammation

Answer 10

Methimazole

Question 11

purpose of potassium iodine

Answer 11

protects from radiation exposure

Question 12

six drugs/classes that impair Levothyroxine

Answer 12

1. antacids, PPIs, sucralfate
2. cholestyramine
3. Fe
4. orlistat