25: Thyroid Flashcards
euthyroid sick
critically ill pt but labs dont fit pattern for primary, secondary or tertiary thyroid dysfunction
what can cause euthyroid sickness?
protein shifts, protective effects of decreased metabolism, maladaptive processes
two major concerns about thyroid surgery
- recurrent laryngeal nerve damage
2. removal of parathyroid glands
Explain thyroglobulin to T3/T4
- Synthesized in colloid
- Iodine transported into cell and incorporated into TG -> iodinated tyrosines
- Tg endocytosed and cleaved -> T3 and T4
Diseases in IgG4-related disease
- Mikulicz’s syndrome
- Reidel’s thyroiditis
- Autoimmune pancreatitis
- Inflammatory pseudotumor
- Multifocal fibrosclereosis
- Idiopathic retroperitoneal fibrosis
- Inflammatory aortic aneurysm
What does radioisotope scanning for the thyroid look for?
Hyperfunction
Hot vs cold nodules of the thyroid
Both are most likely to be benign, but if one is going to be malignant its more likely cold
C cells of the thyroid do..?
Calcitonin secretion
which euthyroid condition is painful?
granulomatous thyroiditis
histo of reidel thyroiditis
fibrosis, cells with perinuclear hoff
what thyroid CA does age majorly affect staging?
papillary thyroid carcinoma
where does diffuse sclerosing variant of papillary thyroid carcinoma metz to?
lung, bone, brain, liver
mutation in medullary carcinoma of the thyroid
RET
mnemonics for papillary, follicular, and medullary thyroid carcinoma
- papillary: Papi Larry and psaMOMMA adopted Orphan Annie and her cousins RET and BRAF
- Follicular: 8PAX of RASberry Follicles next to a bundle of Mushrooms
- Medullary: RET & blue (cell) haired MEDiC (c-cells) Amy(loid) needs to TONE it down (calcitonin) on saving MEN
