3- TISSUE RENEWAL, REGNERATION, and REPAIR Flashcards
The process by which there is extensive deposition of collagen.
Fibrosis
Results in the complete restitution of the lost damage or tissue.
Regeneration
The following are examples of labile tissues EXCEPT:
A. Skin epithelia
B. Oral cavity
C. Parenchymal cells of the liver
D. Lining mucosa of all the excretory ducts
C. Parenchymal cells of the liver
Mechanism of stem cells in which with each stem cell division, one of the daughter cells retains its self-renewing capacity while the other enters differentiation.
Obligatory asymmetric replication
Stem cell mechanism in which there is a balance between self-renewing and differentiated cells.
Stochastic differentiation
A change in differentiation of a cell from one type to another is known as ________________.
Transdifferentiation
The capacity of a cell to transdifferentiate into diverse lineages is referred to as ___________.
Developmental plasticity
Somatic stem cells generate rapidly dividing cells called __________.
Transit amplifying cells
The liver contains stem cells/progenitor cells in the _____________.
Canals of Hering
Neural precursor cells are found in which two areas of the adult brain.
Subventricular zone and dentate gyrus of the hippocampus
This is the rate limiting step for replication in the cell cycle.
Restriction point between G1 and S.
This step in cell cycle monitors the integrity of DNA BEFORE replication.
G1/S checkpoint
Aids in cell scattering and proliferation.
HGF/Scatter factor
Most potent growth factor for vasculogenesis and angiogenesis.
VEGF
Growth factor responsible for migration and proliferation of fibroblasts, smooth muscles
PDGF
Growth factor that acts as a growth inhibitor and a potent fibrinogenic agent.
TGF-B
The following are biochemical pathways that utilize intrinsic tyrosine kinase activity EXCEPT:
A. PI3 Kinase Pathway
B. MAP-kinase Pathway
C. IP3 Pathway
D. cAMP Pathway
D. cAMP Pathway
Mobilization of endothelial stem cells and has a role in inflammation.
A. VEFGR-1
B. VEFGR-2
C. VEFGR-3
D. None of the above
A. VEFGR-1
Acts on lymphatic endothelial cells to induce lymphangiogenesis.
A. VEFGR-1
B. VEFGR-2
C. VEFGR-3
D. None of the above
C. VEFGR-3
Located in endothelial cells and many other cells types and considered to be the main receptors for vasculogenic and angiogenic effect on VEGF.
A. VEFGR-1
B. VEFGR-2
C. VEFGR-3
D. None of the above
B. VEFGR-2
Also known as the wear and tear pigment.
Lipofuschin
Provide resilience and lubrication to many types of CT (cartilage in joints).
Hyaluronan
This is the most abundant glycoprotein in BM.
Laminin
Mobilization of endothelial stem cells and has a role in inflammation.
A. VEFGR-1
B. VEFGR-2
C. VEFGR-3
D. None of the above
A. VEFGR-1
