3. Innate Immune Cells and their Roles in Immunity Flashcards
1
Q
Where are complement proteins synthesised?
A
Liver
2
Q
Which pathway is associated with the antibody-antigen complex?
A
Classical pathway
3
Q
Which pathway is associated with pathogens?
A
Alternative pathway
4
Q
C3a effect?
A
Inflammatory mediator
5
Q
C3b effect?
A
Opsonisation and activating C5 to induce MAC
6
Q
C5 effect?
A
MAC
7
Q
C3 deficiency causes?
A
Pyogenic bacterial infections
8
Q
Terminal pathway deficiency of MAC causes?
A
Recurrent infections by Neisseria gonorrhoea or Neisseria meningitidis
9
Q
Deficiency of early components (decreased clearance of dead cells/bacteria) causes?
A
Autoimmunity (ex. SLE)
10
Q
Complement inhibitors deficiency (overactivation) causes?
A
Hereditary Angioedema
