2. Inflammation Flashcards
1
Q
List key signs of inflammation
A
- Redness
- Heat
- Swelling
- Pain
- Loss of Function
2
Q
3 stages of inflammation?
A
- Cell activation (resident)
- Vasodilation/Permeability/Cell adhesion
- Exudation
3
Q
When permeability of immune cells increases, which immune cell exits bloodstream into tissues first?
A
Neutrophils first, then monocytes
4
Q
What do macrophages release?
A
Cytokines + Chemokines
5
Q
How NADPH oxidase system used to kill microbes?
A
Super oxygen radicals + NO = Peroxynitrite (kills microbes)
NADPH oxidase forms super oxygen radicals
NO synthase forms NO
NADPH oxidase + NO synthase are lysosomal enzymes
6
Q
Steps of extravasation?
A
- Rolling adhesion
- Tight Binding
- Diapedesis
- Migration
