3 - Exchange and Transport Sytems Flashcards

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1
Q

What materials need to be exchanged

A

Oxygen , co2 ( respiratory gases)
Glucose, fatty acids, vitamins, minerals (nutrients)
Excretory products ( urea and co2)
Heat

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2
Q

What 2 ways can substance exchange take place

A

Passively ( diffusion / osmosis )
Actively ( active transport)

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3
Q

How do organisms evolve to meet the needs of SA:volume ration

A

Flattered shape so that no cell is ever to far away from the surface
Specialised exchange surface with larger areas to increases SA to volume ratio

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4
Q

Simple diffusion of materials across the surface can only meet needs of……

A

Relatively inactive organisms

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5
Q

Why are there Features of specialised exchange surface

A

To allow effective transfer of material across them by diffusion or activate transport

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6
Q

What are the features of specialised exchange surfaces

A

Large SA to VOL ration to increase. The rate rate of exchange
Very thin so diffusion distance is show and therefore crosses the exchange surface rapidly
Particallly permeable to allow selected material to cross without obstruction
Movement of environment medium eg, air to maintain gradient

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7
Q

How do you calculate rate of diffusion

A

Surface area x differnce in concentration
____________________________________________
Length of diffusion pathway

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8
Q

Where are exchange surfaces located usually and why

A

Inside
As easily damaged

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9
Q

Why do small organisms not need an exchange surface

A

Diffusion across their body surface is suffocating as the distances are short (less that 0.5mm)
Surface area is relatively large

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10
Q

Area of circle formula

A

Pi r ^2

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11
Q

Area of a square formula

A

B x h x l

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12
Q

area of a sphere

A

4/3 pi r ^3

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13
Q

Surface area of a sphere

A

4pi r ^2

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14
Q

What do large organisms do to meet demands of O2 / minerals

A

A specialised exchange surface

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15
Q

What 3 ways does gas exchange happen in insect s

A

1) along a diffusion gradient
2) muscle contraction
3) using water potentials

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16
Q

How does gas exchange age in insects a long a diffusion gradient

A

conc of oxygen decreases along a tracheol
Causes diffusion gradient between atmosphereic O2 and cells
CO2 works in the opposite direction as cells respire

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17
Q

Is diffusion quicker in air or water

A

Air

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18
Q

How does gas exchange in insects
( contraction of muscle )

A

Mass transport
Contraction of muscles in an insect squeeze air in and out which speeds up exchange

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19
Q

How does gas exchange in insects
( water potential)

A

The ends of the tradheoles are filled with water
During active periods, muscle cells around tracheoles carry out aerobic respiration
Produces lactate which us soluble thus lowers water potential of the muscle cells

Water therfore move into cells from the tracheoles by osmosis. The water in the end of the tracheoles decrease in volume thus increasing the amount of water which may fit in

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20
Q

If you increase air into the tracheoles in an insect what does it lead to

A

Greater evaporation of water

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21
Q

How can you reduce water loss from insects

A

Hairs whichh trap water
The spiricles close most of the time

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22
Q

What are spiracles

A

Pores at the end of tracheoles om surface of insect
They can open and close by valves

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23
Q

What can happen when spiracles are open

A

Water Vapor can evaporate so insects may have them closed

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24
Q

Why do spiracles open periodically

A

To allow gas exchange

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25
Q

What are the similarities between stomata and spiricles

A

Open and close to reduce water loss
Positioned on the outside of the organism

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26
Q

Differences of spiracles and stomata

A

Spiracles have valves
Stomata have guard cells

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27
Q

Limitations of insects

A

Relies a lot on diffusion
Requiring a short diffusion pathway
The insect therefor has to be relative,y small
(Super hornets defy this)

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28
Q

what does photosynthesis use and release

A

Use co2
Release O2

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29
Q

What gases dowm respiration requires and which gas is released

A

Requires O2
Releases CO2

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30
Q

What reduces gas exchange with external air
In plants

A

At time gases for, one process can be used by the other
(respiration and photosynthesis)

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31
Q

Where does most of the O2 go from photosynthesis in plants and where does some go

A

Most diffuses out of lease but some used in respiration

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32
Q

Describe how gasses move out of leaves

A

Diffusion in the gaseous phase ( more rapid than in water )
No living cell is far from external air + therfore sources of O2 and CO2
short diffusion pathway, air spaces to provide very large Sa:V of loving tissues

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33
Q

Is there any specific transport system for gases in plants.

A

No there are just adaptations that cause raid diffusion

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34
Q

How does a leaf have a short diffusion pathway

A

As no cell is far away from the stomata
As airspace’s interconnect cells

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35
Q

Adaptations in plants for rapid diffusion

A

Shot diffuion pathway
Large SA od mesophyll cell for rapid diffusion

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36
Q

Where are the stomata located

A

Underside of leaves

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37
Q

What are stomata surrounded by

A

Guard cells
Which open and close the stomata pore

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38
Q

What do guard cells do

A

Control the rate of gaseous exchange and prevent loss of too much water by evaporation

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39
Q

What are the layers of a leaf blade

A

Waxy cuticle
Upper epidermis
Palisade layer }
Air spaces } spongy mesophyll
Lower epidermis }

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40
Q

What are phloem and xylem known as

A

Vascular bundle

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41
Q

What does the phloem transport

A

Sucrose + minerals

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42
Q

What does the xylem transport

A

Water + minerals

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43
Q

How many times denser us water than air and with what fraction of O2

A

1000 times denser with 1/30th the O2

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44
Q

How many time more viscous than air is water

A

100x

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45
Q

For fish Moving water in and out under water would use too much energy So what do they do

A

Only in one direction in counter current with bloof
Counter current flow maintains a favourable conc. gradient across the entire exchange surface

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46
Q

How do fish obtain the oxygen needed form the water

A

By the gills
As water flows of the bill surface respiratory gases are each edged between the blood and water
As % of dissolved oxygen in water is much less than air there are high rate of oxygen extraction form water

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47
Q

T or f
Fish have a closed circulatory system

A

Yes

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48
Q

What does it mean that fish have a closed circulatory system

A

The blood is entirely contained within the vessel

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49
Q

Do fish have a double circuit system

A

No single

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50
Q

What is a gill cover called

A

Operculum

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51
Q

What is inspiration

A

Mouth open

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52
Q

What is expiration in fish

A

Mouth closed

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53
Q

Describe fish gills

A

Many folded which are supported and kept apart for each other by the water
This gives them a high SA

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54
Q

How does gas exchange occur in fish

A

Diffusion vetween the water and blood across the gill memebrane and capillaries
The operculum permits exit of water and acts as a pump

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55
Q

Describe inspiration in fish

A

Oral valve opened
Mouth cavity expands taking in water through open mouth
Operculum is closed and moved outwards to assist water intake

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56
Q

Descirbe expiration in fish

A

Oral valve shirt s
Mouth cavity contracts forces water back across the gills
Operculum is open

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57
Q

What is rhe bony bar in fish called

A

Branchial arch

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58
Q

Describe how gas exchange rate in fish is optimised

A

A constant steam of oxygen rich water flows over the gill filaments in the opposite direction to the direction of blood flow through the gills. This is called counter current flow

Blood flowing through the fill capillaries Will encounter water of increase ot oxygen content , so the conc gradient for O2 across the grill is manintian across the entire distance of the hill lamella

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59
Q

What would happen if fish exchanged gas is parallel current flow

A

Wouldn’t achieve the same oxygen extraction r stem as conc across frill would quickly equalise

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60
Q

What vessel takes blood away form the bill

A

Efferent vessel

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61
Q

What vessel brings deoxygenated blood to the gill

A

Afferent vessel

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62
Q

What are gill plates

A

Folds in lamellase
Single cell layer
It’s the Exchange surface

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63
Q

What is the thickest part of the stomatal cell

A

Inner wall

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64
Q

What is the type of plant derived form a seed which contains two cotyledons

A

Dicotyledonous

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65
Q

What needs to be exchanged within the environment in an organism

A

Oxygen and nutrients
Waste products, co2 urea
Heat

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66
Q

How easy the exchange of substances depends on what

A

the organisms surface area to volume ratio

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67
Q

In single celled organisms how do substances exchange
And how fast

A

Can diffuse directly out of or into the cell across the cell surface membrane.
Diffusion rate is quick becuase of the small distance the substance have to travel

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68
Q

How does a single felled organism exchange surface and how fast

A

Diffuse directly across the cell surface membrane
Diffusion rate is quick becuase of the small distance

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69
Q

In multicellular animals why is diffusion across the outer membrane too slow

A

Some cells are deep within the body (there is a large distance between them and the outside environment)
Larger animals have a low surface area to volume ratio. It’s difficult to exchange enough substances to supply a large volume of animal through a relatively small outer surface

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70
Q

How do multicellular organism exchange substances

A

Exchange organs
Mass transport (eg, blood to carry glucose and O2, and I o ants water and solutes)

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71
Q

What 2 things does the rate of heat loss depend on

A

Shape and Size

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72
Q

Why does the rate of heat loss depend on surface area

A

Is an organism has a large volume it’s SA is relatively small, this makes it harder for it to lose heat from its body, if an organism is small is has a relatively large SA so heat is lost more easily. This means smaller organisms need a relatively high metabolic rate in order to generate enough heat to stay warm

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73
Q

How does shape effect rate of heat loss

A

Animals with a compact shape have a small surface area relative to their volume ratio - minimising heat loss form the surface
Animals weight less compact shape have a larger surface area relative to volume thus increases heat loss form the surface
Weather an animal is compact or not depends on the temp of the environment

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74
Q

Animals with hight surface area to volume ration tend to lose more water. How have some small desert mammals adapted

A

Kidney structure adaptations so they they produce less urine to compensate

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75
Q

To support their high metabolic rates what to small mammals livening in cold regions do

A

Need to eat large amounts of high energy food such as seeds or nuts

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76
Q

What adaptations do small mammals have when weather gets could

A

Thick layers of fur
or hibernate

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77
Q

How have larger organisms libing in hot regions adapted

A

Eg,
Elephants lathe flat ears to increase Sa to vol rayon
Hippos spend most day in water (behavioural adaptation)

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78
Q

What are Xerophytes
+ examples

A

Plants with are adapted to survive in very dry conditions
Marram grass / cacti

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79
Q

Feature or marram grass

A

Lives on Sandy ground where there is little water + may be very salty
Thick cuticle to reduce water loss
Stomata in pits
Pits surrounded by hairs, there trap layers of moisture outside stomata reducing diffusion gradient so less water is lost in transpiration

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80
Q

What are hinge cells

A

Allows leaf of marram grass to roll up when short of water so that stomata are not exposed to wind or dry air

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81
Q

What are some general features of xerophytes

A

Long shallow spread our roots
Swollen succulent stem
Leaves reduced to spikes
Round shape
Hairs on surface to reflect light

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82
Q

Why do xerophytes have long shallow spread out roots

A

Absorbs more water

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83
Q

Why do xerophytic plants have swollen succulent stem

A

To retain water

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84
Q

Why do xerophytic plants have leaves reduces to spikes

A

To reduce water loss ( as reducing SA to volume ration)

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85
Q

Why do xerophytic plants have leaves reduces to spikes

A

To reduce water loss ( as reducing SA to volume ration)

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86
Q

Why do xerophytic plants have round shape

A

Reduces SA to volume ratio

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87
Q

What do most exchange surfaces have in commmen

A

Large surface area
Thin
steep conc. gradient

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88
Q

Explain gass exchange in fish

A

Water, containing oxygen, enters the fish through its mouth and passes out through the gills.

2) Each gill is made of lots of thin plates called gill filaments,
which give a big surface area for exchange of gases.

3) The gill filaments are covered in lots of tiny structures called
lamella
(plural = lamellae)
lamellae, which increase the surface area even more.
4) The lamellae have lots of blood capillaries and a thin surface layer of cells to speed up diffusion.

5) blood flows through the lamellae in one direction and water flows in the opposite direction. This is called a counter current system. It maintains a large conc gradient between water and the blood. Thus conc of oxygen in the water is always high than in the blood so as much oxygen as possible diffuses form the water into the blood

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89
Q

Insects have microscopic air filled pipes called what?

A

Tracheae

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90
Q

Describe gas exchange in insects

A

Air moves into the tracheae through pores called spiracles

Oxygen travels down the conc gradient towards the cells

The tracheae branch off into smaller tracheoles which have thin permeable walls and go to individual cells. This means that oxygen diffuses directly into the respiring cells.

Carbon dioxide for the cells move down its own conc gradient gradient towards the spiracles to be released into the atmosphere

Insects use rhythmic abdominal movements to move air in and out of spiracles

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91
Q

What gases are needed in plants and why

A

CO2 FOR photosynthesis
o2 for respiration

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92
Q

What is the main gas exchange surface for dicotydonous plants

A

Mesophyll cells

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93
Q

What are th spores in the epidermis of the leaf called

A

Stomata
(Singular stoma )

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94
Q

How are you mesophyll cells adapted for their function

A

Larger SA

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95
Q

What controls the opening and closing of the stomata

A

Guard cells

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96
Q

How do insects minimise water loss

A

Close their spiracles using muscles
Also waterproof waxy cuticles all over their body and tiny hairs aorund their spiracles, both which reduce evaporation

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97
Q

How does water levels effect the opening or closing of stomata

A

Water enetrees the guar d cells making them turgid which opens the stomatal pore.
If a plant gets dehydrated the guard cells lose water and become flaccid which closes the pore

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98
Q

What are xerophytes

A

Plants adapted for life in warm dry windy habitats where water loss is a problem

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99
Q

What are some xerophytic adaptations

A

Stomata sunk in pits that trap moist air, reducing the concentration gradient of water between the leaf and the air. This reduces the amount of water diffusing out of the leaf and evaporating away.
• A layer of ‘hairs’ on the epidermis — again to trap moist air round the stomata.
• Curled leaves with the stomata inside, protecting them from wind (windy conditions increase the rate of diffusion and evaporation).
• Areduced number of stomata, so there are fewer places for water to escapes.
• Wary, waterproof cuticles on leaves and stems to reduce evaporation.

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100
Q

What must a gas exchange surface be like

A

Thin
Large SA
constantly ventilated

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101
Q

any factor that effects a gas exchange surface will effect what

A

Efficiency of gas exchange

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102
Q

Why do we need a breathing system

A

-all aerobic organisms require constant O2 to release ATP
- Build up of co2 - toxic to body (as acidic and can cause harm to enzyme action / organelles) - -volume O2 needed and vol ifCO2 removed is greater than that can be delt with by diffusion alone
- mammals also need to maintain body temp + have high metabolic c respiratory rates

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103
Q

Where are the lungs loacted in humans

A

In thorax protected by rib cage

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104
Q

Why can’t lungs exits outside the body

A

Air is not dense enough to support and protect the delicate structures
They would also dry out if outside the body

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105
Q

What is pulmonary ventilation

A

Total volume of air moved into the lung in one minute

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106
Q

Pulmonary ventilation calculation

A

Pulmonary ventilation = tidal volume X ventilation rate

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107
Q

What is tidal volume

A

Volume of air normally taken in at each breath when the body is at rest

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108
Q

What is tidal volume usually around

A

5dm-3

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109
Q

What is ventilation rate

A

The number of breaths taken in one muinet

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110
Q

What is ventilation rate normally

A

12-20 breaths in healthy adult

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111
Q

Units for ventilation rate

A

Dm3 min-1

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112
Q

Describe inspiration

A

The external intercostal muscles contract, while internal intercostal muscles relax

The ribs are pulled upwards and outwards, increasing the volume of the thorax

Diaphragm muscles contract, causing it to flattern, also increases the volume of the thorax

The increased volume of the thorax results in reduction of pressure in the lungs

Atmospheric pressure is now greater than pulmonary pressure, and so air s forced into the lungs

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113
Q

Describe expiration

A

The internal intercostal muscles contract, external intercostal muscles relax

Ribs move down and in, decreasing thorax volume

diaphragm muscles relax, returns to its upwardly domes position, decreasing volume of thorax

Decreased volume of thorax in cereals pressure in lungs

Pulmonary pressure is now greater that that of the atmosphere and so air is forced out of the lungs

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114
Q

Explain how air gets to the alveoli

A

as you breathe in air enters the trachea
The trachea splits into two bronchi - one bronchus leading to each lung
Each bronchioles then branched off into smaller tubes called bronchioles
The bronchioles end in small ‘air sacs’ called alveoli

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115
Q

What does ventilation consist of

A

Inspiration
Expiration

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116
Q

Is inspiration active or passive

A

Active

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117
Q

Is expirationactive or passive

A

Passive

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118
Q

Can expiration be forced

A

Yes

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119
Q

What happens during forced expiration

A

External intercostal muscles relax and inter costal muscles contract, pulling the rib cage further down and in
during this time , the movement of the two sets of intercostal muscles is said to be antagonistic

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120
Q

What is each alveolus made from

A

Single layer of thin , flat cells called alveolar epithelium

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121
Q

What are alveoli surrounded by

A

Network of capillaries

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122
Q

Descirbe gas exchange in the alveoli

A

O2 diffused out of the alveolu across the alveolar equilibrium m and into haemoglobin in the blood

Co2 diffuses into the alveoli from, the blood and is breathed out

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123
Q

Alveoli adaptation for gas exchange

A

Thin - short diffusion pathway
Large SA
Steel conc gradient - maintained by the flow of blood and ventilation

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124
Q

What is forced expiratory volume (FEV)

A

The maximum volume of air that can be breathed out in 1 second

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125
Q

What js forced vital capacity (FVC)

A

Maximum volume of air it is possible to breathe forcefully out of the lungs after a deep breath in

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126
Q

How can you figure out tidal volume, ventilation rate

A

Spirometer

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127
Q

How does TB effect the lungs

A

When someone becomes affected with tuberculosis bacteria, the immune system cells build a wall around the bacteria in the lungs. This form small, hard lumps known as tubercles
Infected tissue within the tubercles die and the gas is exchange surfaces damaged so tidlevolume is decreased
Reduce tide avoid means less can be inhaled at each breath so in order to take enough oxygen, they have to breathe faster so ventilation rate is increased .
Common symptoms therefore include persistent cough , coughing up blood and mucus, chest pains, shortness of breath and fatigue

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128
Q

How does fibrosis affect the lungs?

A

Fibrosis is the formation of scar tissue in the lungs. This can be result of infection exposure to a substance like asbestos or dust.
Scott tissue was thicker less elastic than normal lung tissue
Means lungs are less able to expand them so can’t hold as much air as normal so tidle volume is reduced There is a reduction in rate of gas exchange and diffusion slow across a thicker scarred membrane.
Symptoms include shortness of breath, dry cough, chest, pain, fatigue, and weakness

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129
Q

How does asthma affect the lungs?

A

Asthma is respiratory condition where airways become inflamed and irritated
During an asthma attack, the smooth muscle lining of the bronchioles contracts and a large amount of mucus is produced. This causes construction of the airways, making it difficult to breathe airflow in and out of the lungs is reduced so less oxygen enters the alveoli and moves into the blood reduced airflow means the forced expiratory volume is reduced Symptoms include wheezing, tight chest and shortness of breath

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130
Q

What is the effect of emphysema on the lungs

A

Emphysema is a lung disease caused by smoking and long-term exposure to air pollution. This causes inflammation, which tracks phagosites the area the phaosites producd anenzyme that breaks down the elastin, which is a protein found in the wars of the alveoli elastin is elastic. It helps alveoli to return to the normal shape after inhaling an exhaling Loss of elastin means I can’t recoil to as well. It was destruction of the alveoli wall which reduces the surface area of the alveoli so the rate of gas is exchanged decreases. The symptoms often include shortness of breathe and wheezing

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131
Q

What is the result of a reduction in gas exchange rate?

A

Less oxygen is able to diffuse into the bloodstream, the body cells receives less oxygen, and the rate of aerobic respiration is reduced. This means less energy is released, so the suffers often feel tired and weak.

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132
Q

Does correlation mean one thing causes another?

A

Not always

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133
Q

What should be the condition of your dissecting tools?

A

Clean, sharp and free from rust as blunt tools don’t cut as well and can be dangerous

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134
Q

In a lung dissection, how could you inflate the lungs?

A

Attach a piece of rubber tubing to the trachea and pump air into the lungs, using a foot or bicycle pump. Lungs will deflate by themselves because the last in the walls of the elastin in the walls of the alveoli

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135
Q

What is the trachea supported by?

A

C shaped rings of cartilage

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136
Q

How should you cut open the trachea in a lung dissection

A

Cartilage is tough you won’t open the trachea it’s best to cut it length way down the gap in the sea shaped rings use dissecting scissors or scalpels

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137
Q

How should you dissect a fish gill?

A

Place on a dissection tray,
gills are located on either side of a fish head, and they’re protected on each side by a bony flap called the operculum and supported by Gil arches
to remove the gillspush back to the operculum, use scissors to remove the gills . Cut each arch through the bone at the top and the bottom

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138
Q

How to carry out dissection on an insect

A

Fix insect dissecting board with pins to hold it in place,
Cut and remove a piece of exoskeleton from along the length of the insects abdomen. You can examine this trachea optical microscopes.

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139
Q

Ethical issues of dissecting animals

A
  • morally wrong to kill animals just for dissections (however many dissections that are carried out in schools involve animals that have already been killed for meat)
  • Concerns that animals used for dissection are not always raised in a humane way, (they may be subject to overcrowding, extremes or temps or lack of food or they may not be killed humanely)
  • if animals are raised in school it’s important they are looked after properly and killed humanely to minimise suffering or distress
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140
Q

Features of the alveoli

A
  • larger Sa to vol ratio
  • movement of internal medium (eg, blood flow) maintain a diffusion gradient
  • movement of environmental medium (air constantly moving in)
  • very thin
    -Partially permeable
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141
Q

Capillaries around the alveolu are ………, so what do red blood cells have to do

A

Thin
Squeeze through which increases the Sa of contact - they are also slowed so allows more time for diffusion

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142
Q

What % of oxygenated air is oxygen

A

21%

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143
Q

What % of oxygenated air is Co2

A

0.04%

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144
Q

What % of deoxygenated air is oxygen

A

16%

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145
Q

What % of deoxygenated air is co2

A

0.4%

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146
Q

What is digestion

A

The process by which larger molecules are hydrolysed by enzymes into small molecules which can be absorbed and assimulated

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147
Q

What does assimulated mean (digestion )

A

A part of the new composition

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148
Q

What does salivary amylase do

A

Hydrolysis alternate glycosidic bonds in starch to Disaccharide maltose in mouth

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149
Q

What maintains the PH in mouth and why

A

Minerals
For amylase optimum ( neutral)

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150
Q

why does no further breakdown happen in the stomach from amylase

A

Acidic conditions denature the amylase enzyme

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151
Q

Food in Small intestines - the remaining starch to maltose is broken down by what

A

pancreatic amylase hydrolase

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152
Q

What PH is the small intestines and how is it maintained

A

7-8
Bile

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153
Q

Maltose disaccharide is then hydrolysed into ……….. by ……….. in the ………..

A

Alpha glucose
Maltase
Ileum

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154
Q

How does maltase in the ileum work

A

Muscles in the intestine walls push food along ileum ( it’s epithelial lining produces the disaccharide maltose)

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155
Q

Is maltose secreted into the lumen of ileum

A

No

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156
Q

What is maltase a part of

A

The cell surface membrane of the epithelium cells of the ileum

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157
Q

What can maltase be described as

A

Maltase is membrane bound disaccharridase

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158
Q

Where is sucrase

A

Found in memebrane of the small intestines

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159
Q

Where is lactase found

A

Small intestine linning

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160
Q

What are proteins hydrolysed be

A

Peptidases

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161
Q

What do endopepridases hydrolyse

A

The peptide bond between amino acid in the centre of the molecule

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162
Q

What does exopeptidase hydrolyses

A

Terminal peptide bonds between amino acids at the end of each molecule , they release dipeptides and single amino acids

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163
Q

What does dipeptidase hydrolyse

A

The bond between 2 amino acids

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164
Q

Where are dipeptidase found

A

Part of the CSM of ilium epithelial cells
( they are membrane bound )

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165
Q

What hydrolysis lipids

A

Lipase

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166
Q

Where is lipase produced

A

Pancrease

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167
Q

What do lipase specifically hydrolyse to form what

A

Ester bonds found in triglycerides to form fatty acids and monoglycerides

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168
Q

What is a monoglyceride

A

Glycerol and 1 fatty acid

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169
Q

How does lipase work

A

fats and oils firstly split into tiny droplets called micelles by bile salts made in the liver (emulsification) this increases surface area so that the action of lipases is sped up

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170
Q

Why can’t large biological molecules cross cell membranes
And what does this mean

A

Too big
Can’t be absorbed form the gut into the blood

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171
Q

How can large molecules be broken down into smaller momlecukes

A

Hydrolysis reactions

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172
Q

What are hydrolysis reactions

A

Breaks bonds by adding water

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173
Q

Why are differnt enzymes needed to catalyse the breakdown of differnt food molecules

A

As enzymes only work with specific substrates

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174
Q

What is amylase

A

A digestive enzyme that catalyses the conversion of starch int the smaller sugar maltose

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175
Q

How does amylase digest starch

A

Hydrolysis of glycosidic bonds in starch

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176
Q

Where is amylase produced

A

Salivary glands
Pancrease (releases amylase Into small intestines)

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177
Q

What are membrane bound disaccharides and what do they do

A

Enzymes that are attached to the cell membrane of epithelial cells losing the ileum
Break down disaccharides into monosaccharides (involving hydrolysis of glycosidic bonds)

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178
Q

What enzyme breaks down maltose into what

A

Maltase
Glucose + glucose

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179
Q

What enzyme breaks down sucrose into what

A

Sucrase
Glucose + fructose

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180
Q

What enzyme breaks down lactose into what

A

Lactase
Glucose + galactose

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181
Q

How can monosaccharides be transported across the cell membrane of ileum epithelial cells via what

A

Transporter proteins

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182
Q

What does lipase catalyse the breakdown of into what

A

Lipids into monoglycerides and fatty acids

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183
Q

How does lipase work

A

Involves hydrolysis of ester bonds in lipids

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184
Q

Where are lipases made and where do they work

A

Pancrease
Small intestines

185
Q

Where are bile salts produced and what do they do

A

Produced by liver and emulsify lipids
Causes the lipids to from small droplets

186
Q

Why is bile salts important

A

Several small lipid droplets have a bigger surface area than a single large droplet
So the formation of small droplets greatly increases the surface area of lipid that’s available for lipases to work fro,

187
Q

Once Lipid has been broken down, the moniglycerides and fatty acids stick with bile salts to from what

A

Tiny structures called micelles

188
Q

What are protease?

A

Enzymes that catalyse the conversion of proteins into amino acids by hydrolysing the peptide bonds between amino acids

189
Q

What is endopeptidase?

A

Ask to hydrolyse peptide bonds within a protein

190
Q

Examples of endopeotidase
+ where they are synthesised + secreated

A

Trypsin
Chymotrtpsin
Pancrease - small intestines

Pepsin
Released into stomach by cells in stomach linning - only works in acidic conditions (hcl in stomach)

191
Q

What is exopeptidases

A

Act to hydrolyse peptide bonds at the end of the protein molecule
They remove single amino acids from proteins

192
Q

Examples of exopeptidase

A

Dipeptidases work specifically on depeptides
They act to separate rhe two amino acid that make up andipeptide by hydrolysing the peptide bond between them

Oftern loacted in CSM of epithelial cells in the small intestines

193
Q

How is glucose absorbed in gut

A

By active transport with sodium ions via co transport proteins

194
Q

How is galactose absorbed

A

Active transport with sodium ions via cotransporter proteins

195
Q

How is fructose absorbed

A

Facilitated diffusion through a differnt transporter protein

196
Q

What do micells help to move, monoglycerides and fatty acids towards? 

A

Epithelium,

197
Q

Because micelles is constantly break up and reform they can release…………. Amd …………. Which allow them to be………

A

Monoglycerides
Fatty acids
Absorbed

198
Q

Are whole micelles taken up across the epithelium

A

No

199
Q

How are fatty acids and monoglycerides moved across epithelium cell membrane

A

They are lipid soluble so can diffusion directly

200
Q

How are amino acids absorbed

A

Sodium ions are actively transported out of the epithelial cells into the ileum itself.
They then diffuse back into the cells through sodium-dependent transporter proteins in epithelial cell membranes, carrying the amino acid with them

201
Q

What does RBC contain

A

Haemoglobin

202
Q

What is haemoglobin

A

Large protein with a quaternary structure (4 polypeptide chains)

Each chain has a ham group which contains iron ion and gives it its red colour

203
Q

What can haemoglobin bedescribed of having for oxygen

A

A high affinity for oxygen

204
Q

How many O2 can each haemoglobin molecule carry

A

4

205
Q

In the lungs, what joins to haemoglobin to form what

A

Oxygen
oxyhemoglobin

206
Q

Is haemoglobin to oxyhemoglobin reversible

A

Yes

207
Q

Is heamoglobin found in many differnt organisms

A

there are many chemically similar types of haemoglobin found in many differnt organisms , all of which carry out the same function

208
Q

The partial pressure of oxygen (pO2) is a measure of what

A

Oxygen concentration

209
Q

The greater the conc of dissolved oxygen in cells, the …….. the partial pressure

A

Higher

210
Q

The partial pressure of carbon dioxide (pCO2) is a measure of what

A

The conc of CO2 in a cell

211
Q

Haemoglobin affinity for oxygen varies depending on what

A

It’s partial pressure of oxygen

212
Q

Oxygen loads onto haemoglobin to form oxyheamoglbin where there’s a ……
PO2
Oxyheamoglobun unloads its oxygen where there is a …….. pO2

A

High
Lower

213
Q

Where does oxygen enter the blood capillaries
+ how

A

At the alveoli in the lungs
Alveoli have high pO2 so oxygen loads onto haemoglobin to from oxyhemoglobin

214
Q

when a cell respires what happens to the pO2

A

It lowers

215
Q

Where does red blood cells deliver oxyhemoglobin

A

To respiring tissue

216
Q

What does a dissociation curve show

A

How saturated the haemoglobin is which oxygen at any partial pressure

217
Q

What does 0% saturation on a dissociation curve mean

A

None of the haemoglobin molecules are carrying any molecules

218
Q

What does 100% saturation on a dissociation curve mean

A

every haemoglobin molecule is carrying the maximum of 4 molecules of oxygen

219
Q

Why is a dissociation curve s shaped

A

When haemoglobin combines with the first O2 molecule, its shape, alters in a way that makes it easier for other molecules to join two, but as the haemoglobin starts to become saturated it gets harder for more oxygen molecules to join as a result, the curve has a steep bit in the middle where it’s really easy for oxygen molecules to join the shallow bit each and is where it’s harder when the curves steep a small change inO2 cause a big change the amount of oxygen carried by the haemoglobin

220
Q

haemoglobin gives up its oxygen more readily at .,…….. partial pressures of co2

A

Higher

221
Q

When cells respire what do they produce and what does this raise

A

Co2
PCO2

222
Q

what is rhe Bohr effect

A

When cells respire, they produce CO2, which raises the PCO2. This increases the rate of oxygen unloading( the rate of which Oxy haemoglobin disassociates to form oxygen and haemoglobin) so the dissociation curve shifts, right. the saturation of blood with oxygen is lower for the given PO2, meaning that more oxygen is being released

223
Q

How organisms that live in environments with low concentration of oxygen adapted the haemoglobin to help survive in that particular environment

A

They have haemoglobin with a higher affinity oxygen than human haemoglobin, so their dissociation curves to the left of ours

224
Q

How have organisms that are very active and a high, oxygen demand adapt the haemoglobin to help them to survive

A

Haemoglobin with a lower affinity for oxygen than human haemoglobin the curve is to the right of the human one

225
Q

Haemoglobin + oxygen —> ?
What is special about this reaction

A

Oxyhaemoglobin
It’s reversible

226
Q

Haemoglobin that bind readily with oxygen has what

A

A high affinity for oxygen

227
Q

Describe the structure of haemoglobin

A

Globular protein
4 polypeptide chains
Each chain contains one haem (iron ) group

228
Q

Hb + 4O2 —> ?

What is special about out this reaction

A

Hb(O2)4
It’s reversible

229
Q

Secondary structure of haemoglobin

A

Coiled into alpha helix

230
Q

Tertiary structure of haemoglobin

A

Folded into precise shape

231
Q

Quaternary structure of haemoglobin

A

4 polypeptide chains are linked together to from an almost spherical molecule. Each polypeptide is associated with haemorrhaging group containing ferrous ion ( Fe 2+) . Each ion can bind with a single o2

232
Q

How many oxygen can bind with one haemoglobin protien

A

4

233
Q

Units of oxygen conc

A

Sa O2%
(Oxygen saturation - o2 bound to haemoglobin in blood)

234
Q

For blood leaving the lungs what is the usual oxygen concentration

A

95 -99%

235
Q

What is the PH like at gas exchange surfaces and why

A

higher due to low lever of acidic CO2 as it is constantly being removed

236
Q

How does higher PH effect haemoglobin

A

Changes the shape into one that loads O2 readily amd increases the affinity of haemoglobin for O2, so it’s not released while being transported in blood to tissues

237
Q

Why is there a lower PH at tissues

A

Co2 is being produced by respiring cells
Co2 lowers the PH

238
Q

How does lower PH effect haemoglobin

A

Changed the shape of haemoglobin into one with a lower affinity for O2

239
Q

Describe the effect of heamoglobin transporting oxygen when there is a higher rate of respiration

A

More Co2 produced
Lowwer PH
Greater haemoglobin shape change
More O2 unloaded
More O2 for respiration available

240
Q

Adaptation of ileum to the function of absorbing products of digestion

A

Thin epithelium - once cell thick to increase diffusion rate
Microvilli increasss Sa for absorption
Lacteal

241
Q

What is the lacteal

A

Tiny lymphatic vessel

242
Q

What does the lacteal absorb

A

Fatty cards and glycerol

243
Q

What do blood capillaries absorb

A

Glucose and amino acids

244
Q

How does glucose and fructose and galactose and amino acids absorbed by ileum

A

Diffusion and co-transport

245
Q

Absorption of triglycerides

A

• mono glycerices and fatty acids remain associated with bile salts after emulsification. Form miceues - tiny (4-7 m diamerer)
- as muscles contract and digestive procucus move through ileum the miceues come unto contact with epithelium cells linning the villi.
• here miceles break down releasing one monoglycendes and fatty acids
• as non-polas morecules oncy easy diffuse acoss the csm ento
Epithelial cells
• once inside epithelial cells, monoglycedes and fatty acids are transported to endoplasmic reticulum where they are recombined to form triglycerides
• This process starts in ER and continues un Golgi apparatus :
Triglycerides associated with cholesterol and upoproteins to form chylomicrons . special particles adapted for transport of lipids

Chlyomicrons move out of epithelium cells via excocytosis
They then reach lymphatic capillaries called lacteals (found in centre of each villus)

From the lacteal chylomicrons pass via lymphatic vessels, into the blood system. The triglycerides in the chylomicrons are hydrolysed by an enzyme in the endothelial cells or blood capillaries form where they diffuse into cells

246
Q

Describe the route taken by the blood around the heart

A

Deoxygenated
Vena cava
Right atrium
Right ventricle
Pulmonary artery

Lungs
Oxygenated
Pulmonary vein
Left atrium
left ventricle
Aorta

247
Q

Why do larger organisms need a transport system

A

They have a smaller surface area to volume ratio
So they can’t obtain all O2/glucose they need by diffusion
They need specialised circulator + gas exchange system

248
Q

What 2 reasons increases need for a transport system

A

The lower SA to volume ration and the more active

249
Q

Features of a transport system

A

Water liquid (blood) that readily dissolves substances and can be moved easily around

A closed system of branching vessels to distribute the transport medium to all parts of the organism

A mechanism for moving the transport medium

A mechanism to ensure flow is one direction + a awYbod controlling flow to meet demand

250
Q

In mammals
They have a ……. Blood systems because

A

Closed
The blood is confined to vessels

251
Q

What are the 3 types of vessels

A

Arteries
Veins
Capillaries

252
Q

What vessel brings deoxygenated blood to the heart

A

Vena cava

253
Q

What vessel brings deoxygenated blood to the lungs

A

Pulmonary artery

254
Q

What vessel brings oxygenated bloof to the heart

A

Pulmonary vein

255
Q

What vessel brings oxygenated blood away form the heart to the rest of the body

A

Aorta

256
Q

What vessels are linked with the liver

A

Hepatic

257
Q

Do (most of the time ) arteries have oxygenated or deoxygenated blood

A

Oxygenated

258
Q

Do (most of the time ) veins have oxygenated or deoxygenated blood
- what is the exception

A

Deoxygenated
in the heart

259
Q

What vessels are linked with the kidneys

A

Renal

260
Q

What vessels are linked with the lower limbs

A

Iliac

261
Q

Does haemoglobin change irs affinity for O2

A

Yes under differnt conditions

262
Q

How does HB change its. Affinity fro O2

A

Chages shape in the presents of certain substances
Eg. CO2

263
Q

How does co2 change HB affinity

A

Changes shape of HB
So HB combines more loosely to O2
This causes O2 to be released

264
Q

Does a gas exchange surface or respiring tissue have …..
Have a high o2 conc

A

Gas exchange surface

265
Q

Does a gas exchange surface or respiring tissue have …..

High co2 conc

A

Respiring tissues

266
Q

Does a gas exchange surface or respiring tissue have …..
Low affinity of HB for O2

A

respiring tissues

267
Q

Does a gas exchange surface or respiring tissue result in O2 being associated

A

Gas exchange

268
Q

What is the degree of oxygenation of haemoglobin determined by

A

The partial pressure p(O2) in the surroundings

269
Q

If P(o2) is lower
does HB carry low O2 or high O2

A

Low

270
Q

Why does HB a have a reduced affinity for O2 in presents of Co2

And what is thus called

A

Co2 diffuses into blood to from carbonic acid
Which forms hydrogencarbonate ions that diffuse into plasma
Hydrogen ions remain in the RBC and are mopped up by HB to form haemoglobinic acid
The acid forces unloading of O2 and the Bohr shift effect

271
Q

What way does the Bohr effect shift the curve

A

To the right

272
Q

Why do animals with a larger Sa to vol ration shift the curve to the right

A

They loose heat quickly
So have a high metabolic rate to generate lots of heat
This shifts the O2 dissociation curve to the right
More O2 is neeed in respiring tissues, their Hb unloads it at a higher ppO2

273
Q

Living in an environment with little oxygen requires a
haemoglobin that….

A

Readily combinds with o2

274
Q

An organism with a high metabolic rate needs to

A

release
oxygen readily into the tissues.

275
Q

Why do differnt haemoglobins have differnt oxygen affinit y

A

The shape of the molecule, haemoglobin
molecules have different sequences of amino
acids (different primary protein structure).
❑The shape of the haemoglobin molecules
determines their affinity for oxygen.

276
Q

What are the 3 types of HB

A

Grabbers
Hoarders
Spenders

277
Q

Give an example of a grabber Hb
And which way will the curve shift

A

animals that live at high altitude
To the right

278
Q

Give an example of a hoarder Hb
And why

A

Lugworms are not very active, they spend most of
their time covered by seawater in their burrows.
▪ Oxygen diffuses into their blood from sea water
and haemoglobin transports it to tissues.
▪ When the tide goes out, the lugworm no longer
has oxygenated water to circulate and so it needs
to extract as much oxygen as possible from the
water left in the burrow which contains less and
less oxygen. It has haemoglobin with a high
affinity for oxygen – hoarders

279
Q

Give an example of spenders HB
And why
Which way does the curve shift

A

birds / fish

Flying and swimming are energy demanding processes
They need more o2 for respiration and so their Hb dissociation curve shifts right so more O2 is releases in tissues at higher ppO2

280
Q

What 3 ways is the flow of blood maintained

A

Pumping action of the heart
Contraction of skeletal muscles
Inspiratory movements

281
Q

Describe the path of boood through the blood vessels form the heart

A

Arteries - Carry blood away form heart into…
Arterioles -
Capillaries
Venules
Veins

282
Q

What are arterioles

A

Smaller arteries that control blood flow from artieries to capillaries

283
Q

Learn layers of arteries, capillaries and veins form a diagram

A
284
Q

What blood vessel has the widest lumen

A

Vein

285
Q

Why do some blood vessels have ….
A tough outer layer

A

To Resists pressure changes form both sides

286
Q

What are the tough outer layer of blood vessels made form

A

Connective tissues

287
Q

Why do some blood vessels have ….
A muscle layer

A

To contract to control flow of blood

288
Q

Why do some blood vessels have ….
Elastic layer

A

To maintain blood pressure by stretching and springing back

289
Q

Why do some blood vessels have ….
Thin inner linning (endothelium)

A

Smooth to prevent friction
Thin to allow diffusion

290
Q

Describe the layers of arteries

A

Thick muscle layer
Thick elastic layer
Overall large thickness
No valves

291
Q

Why do arteries have….
A thick muscle layer

A

So can be constricted and dialated to control blood flow

292
Q

Why do arteries have….
Thick elastic layer

A

Blood pressure needs to be kept High in arteries in order to reach extermeties of body
They are stretched at each beat of the heart
It recoils when it relaxes

293
Q

Why do arteries have….
Overall large thickness

A

Stops the vessels bursting under pressure

294
Q

Why do arteries have….
No valves

A

Blood is under constant high pressure and doesn’t flow backwards

295
Q

What is the exception to arteries having no valves

A

The arteries leaving the heart

296
Q

What are the layers of arterioles

A

Muscle layer thicker than arteri3s
Elastic layer thinner than arteries

297
Q

Is the blood in the arterioles under higher or lower pressure than in the artery’s

A

Lower

298
Q

Why do arterioles have….
Muscle layers thicker than arteries

A

Allows constriction of the lumen in order to control blood flow into capillaries

299
Q

Why do arterioles have…
Elastic layer thinner than arteries

A

Blood pressure is lower

300
Q

Is the blood in veins under high pressure

A

No

301
Q

Describe the vein structure

A

Muscles relatively thin
Elastic layer relatively thin
Overall thickness small
Valves

302
Q

Why do veins have…
Relatively thin muscles

A

Doesn’t control flow to the tissues

303
Q

Why do veins have…
Relatively thin elastic layer

A

Low pressure will not cause them to burst

304
Q

Why do veins have…
Overall small thickness

A

No need for thick walls as pressure is low
It also allows them to be easily flattened aiding flow of blood

305
Q

Why do veins have…
Valves

A

Ensures blood doesn’t flow backwards
Body muscles contract
Veins compressed
Pressures blood within them
Forcing blood along vein

306
Q

What is the function of capillaries

A

To exchange O2, CO2, glucose between blood and cells

307
Q

Why is it an advantage for blood to move slowly in capillaries

A

Allows more time for exchange of materials

308
Q

What is the structure of capillaries

A

Thin walls
Numerous + highly branched
Narrow
Narrow lumen
Pores in endothelium

309
Q

Why do capillaries have…
Thin walls

A

So short diffusion pathway between blood and cells

310
Q

Why is capillaries being numerous and highly branching an advantage

A

It creates a larger Sa

311
Q

Why are capillaries narrow

A

Permeate tissue so that no cells far away form a capillary
And a narrow lumen - RBC squeeze flat against the side to bring them closer to the cell

312
Q

Why do capillaries have…
Pores in endothelium

A

Allow WBCs to escape

313
Q

What does blood transport

A

Respiratory gases
Products of digestion
Metabolic wastes
Hormones

314
Q

What supplies blood to the heart

A

Coronary arteries

315
Q

What is tissue fluid

A

The fluid that surrounds cells in tissues

316
Q

What is tissue fluid made from,

A

Small molecules that leaves the blood plasma
Eg, o2, H2O and nutrients

317
Q

Does tissue fluid contain RBC

A

No

318
Q

Why Donets tissue fluid contain RBC

A

They are too large to be pushes through capillary walls

319
Q

Cells take on ……. And …… from the tissue fluid and release……

A

Oxygen
Nutrients
Metabolic waster

320
Q

Where in the capillaries do substances move out of the capillaries
And how

A

The capillary bed
By pressure filtration

321
Q

What is pressure filtration

A

1) at the start of the capillary bed nearest the arteries, the hydrostatic pressure inside the capillaries is greater than tge hydrostatic pressure in the tissue fluid

2)This difference in hydrostatic pressure means an overall outward pressure forces fluid out of the capillaries and into the spaces around the cells, forming tissue fluid.

3) As fluid leaves, the hydrostatic pressure reduces in the capillaries
— so the hydrostatic pressure is much lower at the venule end of the capillary bed (the end that’s nearest to the veins).
4) Due to the fluid loss, and an increasing concentration of plasma proteins (which don’t leave the capillaries), the water potential at the venule end of the capillary bed is lower than the water potential in the tissue fluid.

5) this means that some water re-enters the capillaries form the tissue fluid at the venue end by osmosis

322
Q

Where does and excess tissue fluid go

A

drain3d into the lymphatic system
Which transports this excess fluid from the tissues and puts it back into the circulatory system

323
Q

Where is the heart loacted

A

Between lungs
Enclosed by pericardium

324
Q

What is used to aid movement of heart.

A

pericardium fluid

325
Q

What does rhe pericardium protect the heart from

A

Over expansion

326
Q

What is the valve between the right atrium and right ventricle

A

The tricuspid valve

327
Q

What is the valve between left atrium and left ventricle

A

Mitral valve

328
Q

What is the valve between right ventricle and pulmonary artery

A

Pulmonary valve

329
Q

What is the valave between aorta and left ventricle

A

Aorta valve

330
Q

What are half of heart disease deaths from

A

Coronary heart disease

331
Q

What does CHD effect

A

Coronary arteries

332
Q

What do coronary arteries do

A

Supply the heart with glucose and oxygen

333
Q

How can blood flow be impaired by CHD

A

By a build up of fatty deposits known as atheromas

334
Q

If blood flow to heart muscle is interrupted it can lead to …..

A

Myocardial infarction

335
Q

What is a myocardial infarction

A

Heart attack

336
Q

What is an atheroma

A

Fatty deposits form within the wall of the artery

337
Q

What are atheromas made of

A

Accumulations of wbc that have taken up low density lipoproteins

338
Q

What can atheromas enlarge to form

A

Atheromatous plaques

339
Q

What does atheromatous plaques cause

A

Bulge in the lumen
Takeing up room narrowing of arteries and blood flow is reduced
Leads to an increases risk of thrombosis or aneurism

340
Q

How does an atheromas interrupt the smooth flow of blood
What does this cause

A

It creates a rough surface
Blood clot (thrombus)

341
Q

What is a thrombus

A

Blood clot

342
Q

What can a thrombus cause

A

May block the blood vessel
Rescuing supply of blood
Region deprived of blood oftern Dies as a result of

343
Q

What is an embolism

A

A mobile clot

344
Q

What causes a heart attack

A

Reduced supply of O2 to the muscles of the heart due to a blockage in the coronary arteries
If it occurs close to the junction in coronary artery and Aorta it will stop beating

345
Q

What is an aneurysm

A

Artery walls bewecom weakens or damaged when elastic tissue is lost and hence swell
They may burst and cause internal bleeding

346
Q

Heart disease Risk factors

A

Smoking
Blood cholesterol
Diet

347
Q

How many times more likely are you to suffer from heart disease form smoking

A

2-6 times out of

348
Q

What 2 factors increase risk of heart disease form smoking

A

Carbon monoxide
Nicotine

349
Q

How can carbon monoxide lead to Heart disease

A

Combinds irreversible with heamoglobin to form carboxyheamoglobin which reduces oxygen carrying capacity og blood
The heart has to work harder to deliver the same amount of o2
High blood pressure increases risk of CHd and strokes

350
Q

How does nicotine increase risk of heart disease

A

Stimulates adrenaline production which increases heart rate and raises blood pressure
Makes RBC more ‘sticky’ and leads to high risk thrombosis

351
Q

What is cholesterol

A

An essential component of all cell membranes it is transported in plasma as spheres of lipoproteins

352
Q

What are the 2 types of blood cholesterol

A

High density lipoproteins
Low density lipoproteins

353
Q

What are high density lipoproteins

A

Removed chrolesterol from tissues and transports to liver for excretion
Helps protect against heart disease

354
Q

What are low density lip proteins

A

Transports cholesterol form liver to tissues
Including artery walls which they infiltrated s
Leading to atheroma

355
Q

How can diet increase risk of heart disease

A

High level of salts : raises blood pressure
High levels of saturated fats : increases low density lipoprotein

356
Q

How can diet decrease risk of heart disease

A

Antioxidants (vitamin c)
Reduces risk of heart disease
Non-starch polysaccharides

357
Q

Describe atria

A

have thin walls. They receive blood that is returning to the heart and force blood into the ventricles.

358
Q

Describe ventricles

A

The ventricles have thicker walls than the atria. This is because they have to pump blood a further distance than the atria (out of the heart and to the rest of the body) and withstand higher pressures.

359
Q

Pulmonary vein
Blood flows from…… to …….

A

Lungs
Left atrium

360
Q

Aorta
Blood flows from
…… to …….

A

Left atrium
Body

361
Q

Vena cava
Deoxygenated blood form body enters heart at….

A

Right atrium

362
Q

Pulmonary artery
Blood flows from ,..,,.. to l…….

A

Right ventricle
Lungs

363
Q

What do the truscupid and bicuspid valve do

A

) valves connect the atria to the ventricles. They stop blood flowing back into the atria when the ventricles contract a

364
Q

Describe the route blood takes form left ventricles to left atrium

A

Left ventricle
Aorta
Body tissue
Vena cava
Right atrium
Right ventricle
Pulmonary artery
Lungs
Pulmonary vein
Left atrium

365
Q

Describe double circulation system

A

Blood is pumped through heart twice when it makes a full circuit to ensure blood circulation isn’t to slow

366
Q

What is the left side of the heart responsible for

A

pumping oxygenated blood out the body

367
Q

What is the right side of the heart for

A

Pumps deoxygenated blood to lungs to become oxygenated

368
Q

What is the Importance of the double circulation system in mammals

A

Maintained concentration gradient – this is due to oxygenated and deoxygenated blood not mixing.
Blood pressure to lungs is slower – to avoid damaging delicate tissues and increase time for gas exchange.
Blood pressure to body tissues is higher.

369
Q

What are the plasma proteins

A

RBC
WBC
Platelets

370
Q

What are the blood components

A

Plasma proteins
Ions
Digestion products
Hormones

371
Q

What are the 3 body fluid types

A

Blood
Tissue fluid
Lymph

372
Q

What is another word for interstitial fluid

A

Tissue fluid

373
Q

What is ultra filtration

A

Filtration under pressure

374
Q

What is tissue fluid

A

Water liquids bathes all cells of the body, which is formed from blood plasma

375
Q

What does tissue fluid contain

A

Glusoce
Aa
Fatty acidic
Salts
Oxygen

Also recipes co2 and other waste materials from cells

376
Q

What 2 things from tissue fluid

A

Hydrostatic pressure
osmosis

377
Q

How does hydrostatic pressure form tissue fluid

A

Pressure of the blood form heart contractions forces fluid out of capillaries
Fluid moves out through gaps in the capillary walls
Some hydrostatic pressure form tissue fluid forces fluid back into capillaries - but net movement is only out

378
Q

What moves when fluid is forced out of capillaries due to hydrostatic pressure

A

Dissolved gases and nutrients move with is
But larger plasma proteins and cells do not

379
Q

How does osmosis contribute to formation of tissue fluid

A

A net movement of water from the capillaries due to hydrostatic forces
Fives them a more negative water potential
Water moves down the water potential gradient into the capillaries s

380
Q

How is movement of fluid calculate

A

As a net figure of hydrostatic. Pressure and osmotic pressure

381
Q

Hydrostatic pressure is much …..
At the arterial end of the capillaries then the venous end

So what does this mean for the net movement

A

Higher

Means the net movement is differnt at differnt ends of the capillary network

382
Q

What is oedema
And what is it due to

A

Swelling
Due to a failure of lymphatic vessels

383
Q

How does tissue fluid return to the circulator system

A

Blood at the venous end of the capillaries has a lower hydrostatic pressure than surrounding tissue fluid, hence some tissue fluid is forced back inside capillaries

The remainder drains into lymphatic vessels and is transported in the lymph until it drains back into the blood in subclavian veins

384
Q

Symptoms of a myocardial infarction

A

Pain
Shortness of breath
Sweating

385
Q

How long is the average cardiac cycle

A

0.8 seconds

386
Q

Describe atrial systole

A

Cardiac muscles of atria contact
So volume of atria decrease
So blood pressure in atria increases

387
Q

Describe ventricular systole

A

Cardiac muscles of ventricles now contact
Volume of ventricles start to decrease
Blood pressure in ventricles start to rise
When blood pressure increases above that it n atria the atrioventricular valves shut (audible lubb sound)
Blood pressure contains to rise as ventricular cardiac muscles continues to contact
Blood pressure now becomes greater in ventricles compared with arteries
Semilunar valves which have been shut until now open
Blood flows out of the heart into the aorta and pulmonary arteries

388
Q

What are the 2 audible lubb dub sounds from in the cardiac cycle

A

Lubb - atrioventricular valves smal shut
Dub - semi lunar valves slam shut

389
Q

What is atrial diastole

A

Occurs part way through ventricular systole
Atrial cardiac muscle relaxes
Pressure decreases and blood flows into atria from veins so volume increases

390
Q

What is ventricular diastole

A

Cardia muscles of ventricles relax
Pressure in ventricles start to decrease and volume increases
When blood pressure drops below that in arteries, the semi lunar valves slam shut
On further relaxation, continued increase in volume and drip in pressure brings the blood pressure of the ventricles below that in the atria
Atrioventricular valaves now open and blood starts to flow into the ventricles form the relaxed but filling atria

391
Q

Understand pressure changes in heart cycle - graph

A

.

392
Q

Cardiac contraction is also called what

A

Systole

393
Q

Cardiac relaxation is also called

A

Diastole

394
Q

Define
Heart rate

A

Number of heartbeats per minute

395
Q

Define
Stroke volume

A

Volume of blood ( cm ^3) pumped by heart in one beat

396
Q

Define
Cardiac output

A

Stroke volume multiplied by the heart rate gives you amount of blood (cm3^3) pumped by heart in 1 min

397
Q

Heart rate equation

A

beats

________
Minute

398
Q

Stroke volume calc

A

Blood (cm3)
—————
Beat

399
Q

Cardiac output calc

A

Blood (cm3). #beats. Blood
——————- —————- = ———
Beat. Minuet. Minuet

400
Q

What factors can change the cardiac output

A

Cardiovascular centre in brain
Hormones eg, adrenaline
Stretching of cardiac muscle

401
Q

Where is blood pressure measured

A

In blood vessels barters

402
Q

What is blood pressure determine by

A

Cardiac output and resistance of flow of blood in vessels

403
Q

what is resistance to blood flow affected by

A

Diameter if boood vessels
Narrowwe vessels ( vasoconstriction)
Wider vessels ( vasodilation )

404
Q

What factors effect bp

A

Cardiovascular centre
Smoking
Diet
Adrenaline
Increases blood viscosity

405
Q

How does cardiovascular centre effect bp

A

Diameter of blood vessels controlled by
stimulation of sympathetic and parasympathetic
nerves

406
Q

How does making effect blood pressure

A

Nicotine causes vasoconstriction
› Build up of fatty deposits in vessels

407
Q

How does diet effect bp

A

High fat diet leads to build up of fatty deposits in
blood vessels

408
Q

How does adrenaline effect bp

A

Causes selective Vadoconstriction and vasodilation

409
Q

How does increase in blood viscosity effect bp

A

Excess water loss ( sweating / excessive ruination)

410
Q

What is the control of heart beat cycle

A
  1. SA node starts initial stimulation
    2, a wave of excitation is started
  2. The wave spreads across both atria
  3. Atrial systole - blood I spushed into the ventricles
  4. Excitation reaches the av node
  5. The excitation reached the bottom of the bundle of his
  6. Excitation passes along the purine fibres
  7. The excitation moves up the sides of the ventricles
    9.the ventricles contract in a wringing movement
  8. Blood forces into arteries
  9. The heart is relaxed
  10. The atria refill with blood
  11. The next cycle starts
411
Q

What does xymes transport

A

Water + minerals

412
Q

What does the phloem transport

A

Organic substances
Eg, sucrose

413
Q

• Xylem & phloem tissues run close to each other to form……………(stem & leaves) or……….(roots)

A

Vascular bundle
Stele

414
Q

In a leaf what is at the top of the vascular bundle

A

Xylem

415
Q

In a leaf what is at the bottom of the vascular bundle

A

Phloem

416
Q

Describe the fibres in the xylem tissue

A

Long cells with thickened cell walls for support

417
Q

Describe the parenchyma in the xylem tissue

A

Cells with thin walls generally used as a storage

418
Q

What are the elements of the xylem vessels

A

Dead cells (walls made of lignin, impermeable to water)
The end of the walls break down to form an uninterrupted
pathway for the water (xylem vessels)
Gaps in the walls called pits to allow movements between vessels
and/or living tissues nearby

419
Q

What is transpiration

A

Plants take in water through their roots in the soil
And is lost through the leaves in the transpiration steam

420
Q

Why do plants need to balence water loss and water uptake

A

Stomata open - more gas exchange but also more water loss

Stomata closed - less water loss but also less gas exchange

421
Q

What does the rate of transpiration depend on

A

Temperature
Humidity
Air movement
Light

422
Q

Water potential is always……… inside the moist
mesophyll than the atmosphere so transpiration occurs………..

A

Greater
All of the time

423
Q

How does temp effect transpiration rate

A

As temp increases
Water molecules kinetic energy increase’s
So evaporation increases

424
Q

How does humidity effect transpiration rate

A

Humidity decrease
Evaporation increases

425
Q

How does air movement effect transpiration rate

A

Still air means saturation on the leaves increases
diffusion decrease

426
Q

Why does light intensity effect rate of transpiration

A

As light intensity also affects the stomatal openinng

427
Q

What are hydrophytes

A

Water plants

428
Q

What are xerophytes

A

Plants living in very dry conditions

429
Q

What are mesophytes

A

Plants living in normal conditions

430
Q

How does water move upwards in plants

A

Concentration of water in the air is lower
than within the leaves
• Through the stomata, diffusion makes
water vapour move into the air.
• Water loss from the mesophyll cells lowers
their water potential, so the nearby xylem
vessel replace the lost water (diffusion)
• Water pressure in the xylem (in the leaf)
drops so water moves upwards from the
roots where there is higher pressure

431
Q

What are the 3 water movement theories

A

Cohesion -tension
Root pressure
Capillarity

432
Q

What is cohesion tension theory

A

Water in the xylem vessels is pulled (therefore
under tension) towards the leaves because of
the transpiration (transpiration pull).
Water molecules attract each other, because
they are dipoles. This provides cohesion
(stickiness) of the molecules, hence the
uninterrupted column of water.

433
Q

What is the water movement theories for root pressure

A

In the roots, endodermis cells (around the
xylem vessels) actively transport mineral ions
into the xylem, reducing its water potential
water is drawn in hydrostatic pressure
increases water is pushed upwards
(mainly herbaceous plants)

434
Q

What is the water movement theories - capillarity

A

Water molecules ‘climb up’ in narrow tubes (µm)
because they are attracted (adhesion) to polar
molecules of the tube.
The narrower the tube the higher the water
goes.
(mainly small plants)

435
Q

Movement of water into / across roots

A

Water enters the plants through the root hairs (thin,
permeable, large surface area)…
…moving down a water potential gradient (by osmosis)
Why?
Because the vacuoles of root cells contain a strong
solution of dissolved substances, hence a lower water
potential than the soil

436
Q

What are the possible water pathways through roots

A

Apoplast
between the root cells along the cell walls

Vacuolar
from vacuole to vacuole

Symplast
through the cell membranes , cytoplasm or
plasmodesmata (gaps in the cell walls)

437
Q

As the water approaches the xylem, the
apoplast pathway is blocked by a layer of cells
(endodermis) surrounding the pericycle,……
So

A

Endodermis cells have thickened walls with
suberin (impermeable)
Suberin forms a band around these cells called
Casparian strip
The water is forced into the symplast pathway
and trough pits enters the Xylem

438
Q

How are mineral ions taken up in p
Andy

A

Plants obtain the mineral from the soil (except
carnivorous plants and legumes)
• Nitrogen usually enters the plant as
nitrates/ammonium ions
• Ions move into the roots by diffusion (down the
concentration gradient) or active transport
• Ions move across the roots in solution in the water.
• At the endodermis these ions are actively
transported to by-pass the Casparian bands. Plants
can so be selective of the ion taken in

439
Q

What does phloem tissue transport
And what is this called

A

substances made in
the leaves to all other parts of the plant. This
transport is called translocation

440
Q

What does the phloem transport

A

Sucrose (soluble carbohydrates)
Amino acids
Hormones
Mineral

441
Q

Translocation - transport of sucrose (sugar)
Mass Flow Hypothesis

A
  1. Sucrose is manufactured in leaves from glucose made in photosynthesis
  2. Sucrose is transported by facilitated diffusion into the companion cells
  3. Hydrogen ions are actively transported from companion cells into phloem
    along with sucrose.
  4. This means the contents of the phloem now has a lower water potential than
    the Xylem.
  5. Water from the xylem moves by osmosis into the phloem creating a
    hydrostatic pressure.
  6. Respiring cells are using up sucrose which lowers their water potential.
  7. Water then moves from the phloem into the xylem by osmosis.
    8 The pressure is lowered in respiring cells
    Sucrose moves from source to sink using the hydrostatic pressure gradient.
442
Q

What is the mass flow hypothesis

A

Fluids can move freely in sieve tubes just
following the hydrostatic pressure gradient
Sucrose is actively loaded into the sieve tube
from the source cell (leaves or storage organ)
Water follows the sucrose (osmosis) so the
pressure in the sieve tube increases
A sink cell (respiring/storage tissue) unloads
the sucrose (+water because of the osmosis) so
the pressure in the sieve tube decreases

443
Q

What are the 3 experiments to show phloem transports good substances

A

Using aphids
Ringing experiments
Radioactive tracers

444
Q

experiments to show phloem
transport food substances
1. U s i n g A p h i d s

A

Aphid penetrates the stem into
the phloem using its mouthpart
c a l l e d stylet a n d s u c k s t h e
plant s a p
A feeding aphid can be
a n a e s t h e t i z e d a n d t h e stylet
c u t off
The phloem sap flows out
through the stylet a n d c a n b e
analysed. It is found to contain
s u g a r s a n d other organic
s u b s t a n c e s

445
Q

experiments to show phloem
transport food substances - ringing experiments

A

In the ringing experiment, a ring of bark is scraped away that also
removes the phloem, exposing the xylem. Sugar then attempts to
move down the stem but is stopped by the ring. This is demonstrated
by a bulge of sugar forms above the ring, suggesting that sugar moves
down the stem in the phloem and water is transported by the xylem.

446
Q

experiments to show phloem
transport food substances - radioactive tracers

A

These show the direction of
flow of sucrose, This
method uses radioactive
carbon dioxide (14C). This
radioactive carbon dioxide
is put in a bag over a leaf
and sealed. The carbon
dioxide gets converted into
glucose and an x-ray can
be taken that will show the
radioactive C in the phloem.

447
Q

What is a photometer

A

A piece of apparatus used to estimate transpiration rates
Measure water uptake by a plant but assume the water uptake by plant is directly related to water loss by leaves

448
Q

How can unused a potometer to estimate transpiration rate

A

1) cut a shoot underwater to prevent air from ene tearing the xylem, cut it ata slant to increases surface area available for water uptake
2)Assemble the potometer in water and insert the shoot underwater, so no air can enter.
Remove the apparatus from the water but keep the end of the capillary tube submerged in a beaker of water.
4) Check that the apparatus is watertight and airtight.
5) Dry the leaves, allow time for the shoot to acclimatise, and then shut the tap.
Remove the end of the capillary tube from the beaker of water until one air bubble has formed, then put the end of the tube back into the water.
6) remove the end of the capillary tube from the beaker of water until one air bubble has formed then put the tube back into the water
7) record starting position of air bubbles
8)start a stopwatch and record distance moved by bubble per unit time, the rate of air bubble movement is an estimate of transpiration rate

449
Q

How can you dissect a plant

A

1)Use a scalpel (or razor blade) to cut a cross-section of the stem. Cut the sections as thinly as possible — thin sections are better for viewing under a microscope.
2) Use tweezers to gently place the cut sections in water until you come to use them. This stops them from drying out.
Transfer each section to a dish containing a stain, e.g. toluidine blue O (TBO), and leave for one minute. TBO stains the lignin in the walls of the xylém vessels blue-green.
This will let you see the position of the xylem vessels and examine their structure.
Rinse off the sections in water and mount each one onto a slide

450
Q

What are sieve tube elements

A

Living cells that from the tube for transporting solutes, thus have no nucleus and few organelles

451
Q

What is a companion cell

A

Carry out living functions for sieve cell

452
Q

What are solutes sometimes called

A

Assimilates

453
Q

What makes sure there is always a lower concentration at the sink of the source

A

Enzymes maintain a conc gradient at the source to the sink by chaining the solutes at the sink

454
Q

Explain mass flow hypothesis

A

Active transport is used to actively load the solutes from companion cells into sieve tubes of the phloem at the source
This lowers the water potential inside the sieve tubes so water enters the tubes by osmosis from the Xylem and companion cells
This creates a high-pressure inside the tube at the source end of the phloem

At the sink, salutes are removed from thephloem to be used up this increases the water potential inside the sieve tube so water also leaves the tubes by osmosis
This lowers rhe pressure inside the sieve tubes

The result is a pressure gradient from the source end to the sink end
The gradient pushes solute along the sieve tube towards the sink
When they reach the sink for solute will be used up or stored

455
Q

Give some against evidence for mass flow hypothesis

A

Sugar travels to many different sinks, not just to the one with She highest water potential, as the model would suggest.
The sieve plates would create a barrier to mass flow. A lot of pressure would be needed for the solutes to get through at a reasonable rate.

456
Q

Explain how the translocation of solutes be demonstrated experimentally
Using C14

A

The Translocation of Solutes Can be Demonstrated Experimentally Translocation of solutes in plants can be modelled in an experiment using radioactive tracers.
1) This can be done by supplying part of a plant (often a leaf) with an organic substance that has a radioactive label. One example is carbon dioxide containing the radioactive isotope 14C. This radioactively-labelled COw can be supplied to a single leaf by being pumped into a container which completely surrounds the leal.

The radioactive carbon will then be incorporated into organic substances produced by the leaf (e.g. sugars produced by photosynthesis), which will be moved around the plant by translocation.
The movement of these substances can be tracked using a technique called
autoradiography. To reveal where the radioactive tracer has spread to in a plant, the plant is killed (e.g. by freezing it using liquid nitrogen) and then the whole plant (or sections of it) is placed on photographic film- the radioactive substance is present wherever the film turns black

The results demonstrate the translocation of substances from source to sink over time — for example, autoradiographs of plants
killed at different times show an overall movement of solutes (e.g. products of photosynthesis) from the leaves towards the roots.

457
Q

What evidence support the mass flow hypothesis

A

• there is a pressure within sieve tubes, as shown by sap being released when they are cut.
• the concentration of sucrose is higher in leaves (source) than in roots (sink).
• downward flow in the phloem occurs in daylight, but ceases when leaves are shaded, or at night.
• increases in sucrose levels in the leaf are followed by similar increases in sucrose levels in the phloem a little later.
.metabolic poisons and/or lack of oxygen inhibit translocation of sucrose in the phioem.
- companion cells possess many mitrochondira and readily produce ATP

458
Q

Evidence question the mass flow hypothesis

A

the function of the sieve plates is unclear, as they would seem to hinder mass flow it has been suggested that they may have a structural function, helping to prevent the tubes from bursting under pressure).

not all solutes move at the same speed - they should do so if movement is by mass flow.

sucrose is delivered at more or less the same rate to all regions, rather than going more quickly to the ones with the lowest sucrose concentration, which the mass flow theory would suggest.