3 Anticoagulation - Consultant Flashcards

1
Q

Symoptoms of DVT

A

Pain
Leg swelling
Redness

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2
Q

if patient has eGFR

A

UFH

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3
Q

High risk surgeries include

A

Orthopadedic, hip and knee replacement, gynacological

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4
Q

After surgery continue thromboprophylaxis until

A

mobile or discharge

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5
Q

commonest way to diagnose a DVT?

A

colour duplex scan

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6
Q

how to diagnose PE?

A

Perfusion scan (cannot see on xray)

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7
Q

Wells score tells us (DVT)

A

Which patients to scan and not
Likelyhood that pt is having a DVT
>2 is high
1-2 moderate

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8
Q

Wells score catagories (DVT):

LEARN

A
\+1 for:
Active cancer
Paralysis/ recent plaster
Bedridden/surgery
Tenderness along deep veins system
Entire leg swollen
Calf swelling
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9
Q

D dimer levels indicate

A

….clotting is occurring
D-dimer (or D dimer) is a fibrin degradation product (or FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis

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10
Q

What does the D-dimer test tell us?

A

Negative - rules out DVT

High - further testing required

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11
Q

Which first: D-dimer or wells score?

A

Well’s score

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12
Q

When to use D-dimer test?

A

When the risk is low to EXCLUDE DVT

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13
Q

Well’s score (PE) catagories:

LEARN

A
\+3:
Symptoms of PE
Alternative diagnosis less likely
\+1.5:
Heart rate >100
Immobilisation in past 4 weeks
Previous PE/DVT
\+1:
Haemoptysis
Cancer

High >6 ** Moderate 2-6 ** Low

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14
Q

Learn coagulation cascade slide

A

.

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15
Q

two types of heparin

A

Large UFH
and
LMWH

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16
Q

Route of admin of
UFH
LMWH

A

UFH - IV/SC

LMWH - SC only

17
Q

Which heparins require monitoring

A

UFH - yes - vital

LMWH - no usually

18
Q

Cost of heparins

A

UFH - low

LMWH - high

19
Q

Which heparin has greater
anti-Xa action
antithrombin action

A

LMWH - antiXa

UFH - antithrombin

20
Q

What do you monitor in UFH?

A
  • APTT

- Heprain (antifactorXa) assay is used in specialsed cercumstances (preg,paeds,renal fail)

21
Q

How often to meaure APTT

A

every 4h to start then every 6.

22
Q

Why do we try to avoid UFH?

A

monitoring is intensive

23
Q

Why are clotting tests different for UFH and LMWH?

A

UFH is a bigger molecule which wraps around trapping thrombin