3

Question 1

Where does most fatty acid synthesis occur

Answer 1

liver and adipose tissue

Question 2

Alcoholics

Answer 2

cant really synthesise fatty acids contributing to liver failure

Question 3

precursor for fatty acids

Answer 3

Acetyl CoA

Question 4

How to obtain acetyl CoA

Answer 4

Glycolysis
Pyruvate
Fatty acid breakdown

futile cycle

Question 5

Where in cell does fatty acid synthesis occur

Answer 5

Cytoplasm whereas degredation in mitochondrial matrix

Question 6

First step of fatty acid synthesis

Answer 6

Carboxylation of acetyl CoA to malonyl CoA by acetyl CoA carboxylase 1

irreversible

Question 7

Last step of fatty acid synthesis

Answer 7

Acetyl ACP formed which is a good substrate for thioesterase which hydrolyses to yield palmitate and ACP

thioesterase acts as a ruler

Question 8

Overall reaction for fatty acid synthesis

Answer 8

8 Acetyl CoA + 7 ATP + 14 NADPH + 6 H+ –> Palmitate + 14NADP + 6H + 8CoA + 6H2O + 7ADP + 7Pi

Question 9

How do you get Acetyl CoA into cytoplasm

Answer 9

convert to citrate and through some proteins then back to acteyl coA releasing some NADPH

extra NADPH come from pentose phosphate pathway

Question 10

Elongation and unsaturation of fatty acids

Answer 10

Endoplasmic reticulum

Question 11

When is fatty acid synthesis maximal

Answer 11

when carb levels are high

Question 12

Regulation of fatty acid synthesis allosteric

Answer 12

Acetyl CoA carboxylase stimulated by citrate and inhibited by palmitoyl CoA

Question 13

regulation of fatty acid hormonal

Answer 13

Glucagon and epinephrine inhibit fatty acid synthesis by phosphorylating the carboxylase