3 Flashcards
Determined by the site of administration and the drug formulation
A. Rate of Absorption
B. Extent of Absorption
C. First-Pass Effect
D. Rate of elimination
A. Rate of Absorption
Time it takes for the amount of the drug falls to 50% of the earlier measurement is known as
A. Steady state concentration
B. Half-life
C. Dosing regimen
D. Elimination time
B. Half-life
Which route has 100% Bioavailability
A. Intravenous (IV)
B. Subcutaneous (SC)
C. Intramuscular (IM)
D. Oral (PO)
A. Intravenous (IV)
Greater when administered as a constant infusion than with intermittent dosing
Cumulative Effects
Due to the slow turnover of a physiologic substance that is involved in the expression of the drug effect.
Delayed Effects
Calculated from the dose divided by the AUC
Clearance
Pharmacodynamic variable/s
Neither clearance or volume of distribution
Just enough drug is given in each dose to replace the drug eliminated since the preceding dose
Maintenance Dose
Used for drugs with long half-lives
Loading Dose
Drugs are cleared very readily by the organ of elimination
Flow-limited elimination
Most of the drug in the blood perfusing the organ is eliminated on the first pass of the drug through it.
Flow limited elimination
T or F
Hyperthyroidism increases the half-life of drugs.
FALSE
T or F
Systemic clearance is not affected by bioavailability.
TRUE
T or F
Bioavailability is the concentration of the drug found at the receptor sites.
FALSE
T or F
A drug that is avidly bound to molecules in the peripheral tissues, requires a larger total dose to achieve measurable plasma concentration.
TRUE
