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PCOL 1st Shifting > 2 > Flashcards

2 Flashcards

1
Q

This drug receptor is usually inhibited rather than activated:
A. Regulatory protein
B. Enzyme
C. Transport protein
D. Structural protein

A

B. Enzyme

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2
Q

Binding with these molecules will result to no detectable change in the function of the biologic system:
A. Effector
B.Receptor
C. Inert Binding site
D. Spare receptor

A

C. Inert Binding site

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3
Q

Produces the full maximal effect when receptors are saturated:
A. Full agonist
B. Partial Agonist
C. Competitive Antagonist
D. Irreversible Antagonist

A

A. Full agonist

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4
Q

Secondary messenger that mediate most hormonal response:
A. cAMP
B. Calcium
C. PIP
D. cGMP

A

A. cAMP

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5
Q

The dose at which 50% of the test population exhibit unintended effects:
A. ED50
B. LD50
C. MD50
D. TD50

A

TD50

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6
Q

Maximal efficacy & potency are derived from this
A. Graded dose-response relationship
B. Quantal dose-response relationship
C. Both
D. Neither

A

A. Graded dose-response relationship

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7
Q

Decreased sensitivity acquired as a result of exposure to the drug
A. Idiosyncratic
B. Tolerance
C. Hyporeactive
D. Hypereactive

A

B. Tolerance

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8
Q

Down regulation which varies the drug response is due to:
A. Variation in drug concentration
B. Alteration in endogenous ligands
C. Alteration in receptor
D. Changes in 2nd messenger

A

C. Alteration in receptor

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9
Q

Measured with a graded dose-response curve but not with quantal dose-response curve
A. Maximal Efficacy
B. Potency
C. Clinical sensitivity
D. Tachyphylaxis

A

A. Maximal Efficacy

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10
Q

Drug interaction wherein one drug enhances the effect of another by inhibiting its metabolizing enzyme
A. Additive
B. Antagonism
C. Synergistic
D. Potentation

A

D. Potentation

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11
Q

Binds to the drug inhibited

A

Chemical Antagonst

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12
Q

Binds to the drug receptor

A

Competitive Antagonist / Irreversible Antagonist

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13
Q

Binds via covalent bonds

A

Irreversible Antagonist

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14
Q

Utilizes another regulatory pathway

A

Physiologic Antagonist

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15
Q

Receptor dimerization

A

Tyrosine kinase mediated

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16
Q

Epinephrine

A

G-protein mediated

17
Q

Used by neurons in synapse

A

Ligand-gated Ion channel

18
Q

Increase cGMP phosphodiesterase

A

Gt1 , Gt2

19
Q

Increase phospholipase C

A

Gs

20
Q

Increase adenylyl cyclase

A

Gl1, Gl2, Gl3

21
Q

Decrease adenylyl cyclase

A

Gl1, Gl2, Gl3

22
Q

Opens cardiac K+channels

A

Gt1 , Gt2

23
Q

Most potent

A

drug A / B

24
Q

Most efficacious

A

drug D

25
Q

`Least potent

A

Drug D

26
Q

Least efficacious

A

drug A

27
Q

QUANTITATIVE RELATIONSHIP
Shade A if 1>2 , B if 1<2, C if 1=2
With spare receptors
1. Kd 2. EC50

A

A. 1>2

28
Q

QUANTITATIVE RELATIONSHIP
Shade A if 1>2 , B if 1<2, C if 1=2
Drug Affinity
1. Kd=10 2. Kd= 100

A

B. 1<2

29
Q

QUANTITATIVE RELATIONSHIP
Shade A if 1>2 , B if 1<2, C if 1=2

Margin of safety
1. Therapeutic index=2
2. Therapeutic index = 50

A

C. 1=2

30
Q

VARIATION RELATIONSHIP
Shade A if an increase in 1 is followed by an increase in 2
B if an increase in 1 is followed by a decrease in 2
C if an increase in 1 will not affect 2

1.ED50 2. Efficacy

A

B. increase in 1 is followed by a decrease in 2

31
Q

VARIATION RELATIONSHIP
Shade A if an increase in 1 is followed by an increase in 2
B if an increase in 1 is followed by a decrease in 2
C if an increase in 1 will not affect 2

  1. Irreversible antagonist 2. Emax
A

B. increase in 1 is followed by a decrease in 2

32
Q

VARIATION RELATIONSHIP
Shade A if an increase in 1 is followed by an increase in 2
B if an increase in 1 is followed by a decrease in 2
C if an increase in 1 will not affect 2

1.EC50 2. Potency

A

C. an increase in 1 will not affect 2

33
Q

T or F

LD50 is the median toxic dose and means that 50% of the individuals manifested the toxic effects.

A

FALSE

34
Q

T or F
A very safe drug might be expected to have a very large toxic dose and a much larger effective dose.

A

FALSE

35
Q

T or F
Drug interactions are expected to produce adverse effects.

A

PCOL 1st Shifting (3 decks)

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