1 Flashcards
T or F
Most drugs fall between 100 and 1000 in molecular weight.
TRUE
T or F
Transport of drugs that use special carriers can be saturated.
T or F
Weak bases are usually excreted faster in alkaline urine.
FALSE
T or F
Inert binding sites does not affect pharmacokinetics of drugs.
The science of drug preparation and the medical uses of drugs, precursor of pharmacology.
a. Experimental Physiology
b. Materia Medica
c. Pharmacokinetics
d. Pharmacogenetics
B. Materia Medica
Molecules with no ligands or no known function:
a. antisense oligonucleotides
b. orphan receptors
c. mirco-RNAs
d.siRNAs
B. Orphan Receptors
Study of drug mechanism of action, receptor interactions as well as dose-response phenomena
a. Pharmacodynamics
b. Pharmacogenomics
c. Pharmacokinetics
d. Pharmacogenetics
A. Pharmacodynamics
Specific cell molecules being acted upon by the drug to produce a clinical effect:
a. cell membrane
b. domain
c. ligand
d. receptor
D. receptor
Which of the following processes is best suited for permeation of very large protein molecules into cells?
A. Aqueous diffusion
B. Lipid diffusion
C. Endocytosis
D. Special carrier transport
A. Aqueous diffusion
QUANTITATIVE RELATIONSHIP
A if 1>2
B if 1<2
C if 1=2
Rate of absorption
1. stomach 2. small intestines
QUANTITATIVE RELATIONSHIP
A if 1>2
B if 1<2
C if 1=2
Bioavailability
1. Enteral route 2. Intravenous route
QUANTITATIVE RELATIONSHIP
A if 1>2
B if 1<2
C if 1=2
Bond strength
1. electrostatic 2. covalent
QUANTITATIVE RELATIONSHIP
A if 1>2
B if 1<2
C if 1=2
Response
Full agonist + allosteric activator
Full agonist + partial agonist
VARIATION RELATIONSHIP
Shade A if an increase in 1 is followed by an increase in 2
B if an increase in 1 is followed by a decrease in 2
C if an increase in 1 will not affect 2
- Charge 2. Lipid solubility
Shade A if an increase in 1 is followed by an increase in 2
B if an increase in 1 is followed by a decrease in 2
C if an increase in 1 will not affect 2
- Drug size 2. Rate of diffusion
