3 Flashcards
Biomembranes
Supra-molecular self-organizing structures that consist mainly of lipids and proteins which is hold by weak non-covalent interactions.
Types of Lipids (15 - 80 %): Phospholipids Sterol lipids Glycolipids Minor lipids:
main compound of the lipid bilayer (20 - 50 % of the total lipid content)
cholesterol, improves the barrier function of the membrane inhibiting fast phase transitions in the bilayer during temperature changes (0 - 20 %)
receptors (5-30 %)
Vitamin А and Е, fatty acids etc. (< 1 -2%)
Types of membrane proteins:
Integral proteins
Lipid anchored proteins
Peripheral proteins
Ion channels, proton pumps, trans-membrane receptors
Some G-proteins (signal transduction)
Some enzymes and hormones
Biomembrane functions:
Barrier = low permeability for ions Transport = protein channels, carriers or pumps for active transport of ions or molecules Mechanical = maintains the integrity and shape of cells, Signaling = specific binding sites (receptors) for signaling molecules atalytic = forms a dynamic matrix for enzymes Protecting = protects the cell from different harmful or destructing factors of biological, chemical or physical nature.
Physical properties:
Mechanical– fluidity ⇒ stability and deformability
Electrical-all cellular membranes have a high resistance
Optical -refraction and absorption of light,