282 - Pediatric Cancer Flashcards

1
Q

What is the most common cause of cancer mortality in children?

A

CNS tumors

Second most common malignancy (behind ALL), most common solid tumor

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2
Q

What percentage of childhood caners are due to genetic predisposition?

A

5%

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3
Q

What translocation is associated with Ewing sarcoma?

A

t(11;22)

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4
Q

List 2 cancers more common in children with Down Syndrome

A

ALL

AML

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5
Q

List 2 cancers more commoni in children with neurofibromatosis-1

A

AML

Brain tumors

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6
Q

List 2 tumors mor common in children with Beckwith-Wiedemann syndrome

A

Hepatoblastoma

Nephroblastoma

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7
Q

A 4 year old child presents to the emergency department with fevers for 5 days, weight loss and night sweats. Lymph nodes in the cervical chains and axilla are large and non-tender. Laboratory studies reveal anemia and thrombocytopenia. Which of the following is the most likely diagnosis for this patient?

  1. Hodgkin’s Lymphoma
  2. Acute Myelogenous Leukemia (AML)
  3. Metastatic rhabdomyosarcoma
  4. Acute Lymphoblastic Leukemia (ALL)
  5. Langerhans Cell Histiocytosis
A

d. Acute Lymphoblastic Leukemia (ALL)

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8
Q

Which pediatric malignancy has the best prognosis?

A

ALL

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9
Q

List 2 tumors more common in children with Li-Fraumeni syndrome

A

Osteosarcoma

Rhabdomyosarcoma

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10
Q

A 15 year old male presents to the emergency department with complaints of right knee pain that has gradually been worsening over the last 2-3 months and a new palpable mass to just above the knee. An X-ray is obtained (shown below) and shows a mass to the medial aspect of the distal femur.

What is the most likely diagnosis?

  1. Hepatoblastoma
  2. Ewing Sarcoma
  3. Osteosarcoma
  4. Rhabdomyosarcoma
  5. Hodgkin Lymphoma
A

c. Osteosarcoma

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11
Q

What kind of pediatric cancer most often presents wtih a mediastinal mass?

A

Pediatric lymphoma

May be Hodgkin’s or non-Hodgkin’s

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12
Q

Late effects of cancer therapy can be life threatening in survivors of childhood cancer. Which of the following is not a well-recognized late effect of cancer therapy?

  1. Early death
  2. Accelerated growth
  3. Cardiomyopathy
  4. Mental health disorders
  5. Infertility
A

b. Accelerated growth

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13
Q

What is the most common malignant neoplasm in childhood?

A

Acute Leukemia (ALL)

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14
Q

What is the most common genetic change associated with the development of retinoblastoma?

A

RB1 mutation

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15
Q

A former 23 week premature infant, born at 1000 grams, presents to the pediatrician for evaluation for a palpable right upper quadrant mass. An ultrasound is obtained and showed a large mass within the right lobe of the liver. What is the most likely diagnosis?

  1. Wilms tumor
  2. Osteosarcoma
  3. Ewing Sarcoma
  4. Hepatoblastoma
  5. T-lymphoblastic lymphoma
A

d. Hepatoblastoma

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