265 - Hodgkin's Disease, T-Cell Disorders Flashcards

1
Q

Describe the cell morphology associated with Hodgkin Lymphoma

A

Reed-Sternberg cells

  • Bi-lobed nuclei, prominent nucleoli*
  • Notably CD20- (even though B origin), CD30+, CD15+*
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2
Q

In which T-cell lymphoma is the ALK gene relevant?

What does it tell you?

A

Anaplastic large cell lympoma (ALCL)

  • ALK+
    • Better prognosis
    • More common in peds
    • Results from t(2;5) translocation
  • ALK-
    • Poor prognosis
    • More common in elderly

ALK is a tyrosine kinase receptor

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3
Q

Describe the cell morphology associated with anaplastic large cell lymphoma (ALCL)

What are the relevant markers?

A

Large cells

Horse-shoe shaped nuclei

Nucelar clearing

CD30+, maybe ALK+

ALK status is important for tx; ALK- has worse prognosis

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4
Q

What is the genetic hallmark of ALK+ anaplastic large cell lymphoma? (ALCL)?

A

t(2;5)

  • ALK+ ALCL has a favorable prognosis, seen in peds*
  • ALK- ALCL has a poor prognosis, seen in adults*
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5
Q

What is the most common primary cutaneous T-cell lymphoma?

A

Mycosis Fungoides / sezary syndrome

  • Comes from CD4+ T cells*
  • Loss of CD7*
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6
Q

What cell morphology is associated with mycosis fungoides / sezary syndrome?

A

Small to medium sized T-cells with cerebriform nuclei

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7
Q

What is the classic triad of sezary syndrome?

A

Erythroderma

Generalized lymphadenopathy

Peripheral blood involved w/neoplastic cells with cerebriform nuceli

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8
Q

What is the difference in expression of CD3 between NK cells and T cells?

A
  • NK cells express cytoplasmic CD3
    • CD3- on flow, CD3+ on immunostain
  • T cell express surface CD3
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9
Q

What markers are associated with neoplastic cells in classic (nodular sclerosing) Hodgkin Lymphoma? (3)

A

Reed-Sternberg cells

CD30+

CD15+

CD20-

Vs. nodular lymphocyte predominant will be CD30-, CD15-, CD20+

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10
Q

What virus is most strongly associted with nasal-type extranodal NK or T-cell lymphoma?

A

EBV

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11
Q

Which malignany is caused by HTLV1?

A

Adult T-cell leukemia/lymphoma (ATLL)

Poor prognosis :(

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12
Q

List the 4 pan T-cell antigens

Which are most often lost in T-cell lymphoma?

A

CD2

CD3

CD5*

CD7*

*Most often lost in T-cell lymphoma

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13
Q
A

A. Classical hodgkin lymphoma - nodular sclerosing type

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14
Q

Which lymphoma of B cell origin will be CD20-?

A

Classic hodgkin lymphoma

CD30+, CD15+

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15
Q

Describe the cell morphology and relevant immunophenotype in adult T-cell lymphoma/leukemia

A

Flower-shaped nuclei

CD7-

Cell of origin = peripheral CD4+ T cells

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16
Q
A

A. Anaplastic large T cell lymphoma

  • t(2;5) leads to ALK+*
  • More common in ped*s (ALK- more common in adults)
17
Q

What markers are associated with neoplastic cells in nodular lymphocyte-predominant Hodgkin Lymphoma? (3)

A

CD20+

CD30-

CD15-

Vs. classic will be CD30+, CD15+, CD20-