2.8

Question 1

What reaction is important with the benzodiazepines?

Answer 1

Oxidation at Carbons alpha to Carbonyls and Imines

Question 2

Where do aliphatic oxidation’s take place?

Answer 2

On the terminal methyl (omega) or omega-1 (methyl before terminal methyl)

Question 3

In aliphatic oxydation (hydroxylation) which reaction is preferred?

Answer 3

omega-1 reaction

Question 4

Where does Oxidative N-dealkylation take place?

Answer 4

C-N system

Question 5

N-dealkylations take place on:

Answer 5

Aliphatic Amines Alicyclic Amines Substituted amines

Question 6

Speed of Oxidative N-dealkylations?

Answer 6

Generally fast

Question 7

What happens to oxidation at a carbon alpha to the N?

Answer 7

Gives an unstable carbinolamine

Question 8

Dealkylation rates

Answer 8

3 > 2 > 1 >

Question 9

Which aliphatic groups are dealkylated?

Answer 9

Aliphatic groups with H atoms alpha to the N

Question 10

What do Oxidative O-dealkylations occur on?

Answer 10

Ethers

Question 11

What do Oxidative S-dealkylations occur on?

Answer 11

Thioethers

Question 12

What enzymes are used in Oxidative Deamination?

Answer 12

MFO, MAO, and Diamine oxidase

Question 13

What is MAO?

Answer 13

Flavin containing enzyme located on the other membrane of mitochondria

Question 14

What does Oxidative Deamination occur on?

Answer 14

Only aliphatic amines

Question 15

What is the enzyme for the Oxidation of 1’ and 2’ alcohols?

Answer 15

Alcohol dehydrogenase

Question 16

What is the coenzyme of the Oxidation of 1’ and 2’ alcohols?

Answer 16

NAD+

Question 17

3 enzymes involved in the oxidation of aldehydes?

Answer 17

NAD+ specific aldehyde dehydrogenase xanthine oxidase aldehyde oxidase and others

Question 18

Enzymes involved in Amine Oxidations?

Answer 18

MFO and NADPH-flavin dependent monooxygenases

Question 19

Coenzyme for Reductions

Answer 19

NADPH

Question 20

What is the result of a reduction of an aldehyde or ketone?

Answer 20

1’ or 2’ alcohols

Question 21

What groups does nitroreduction involve?

Answer 21

Both aliphatic and aromatic nitrogen groups

Question 22

3 Mammalian nitroreductase enzymes

Answer 22

aldehyde oxidase

xanthine oxidase

DT diaphorase

Question 23

What is an azoreduction?

Answer 23

Reducion between R-N=N-R’ –>R-NH2 + R”-NH2

Question 24

What does the hydrolysis of Carbamates yeild?

Answer 24

An amine, an alcohol, and a carbon dioxide

Question 25

What enzyme is involved in the hydrolysis of epoxides?

Answer 25

Epoxide hydrase

Question 26

Epoxide stereochemistry

Answer 26

-cis