2.11

Question 1

4 N-acetylations

Answer 1

Amines (aromatic/aliphatic)-most common (only 1’)
Amino Acids
Hydrazines
Sulfamido groups

Question 2

Reaction not that important in xenobiotic metabolism?

Answer 2

Methylation

Question 3

Enzyme and Coenzyme used in methylation

Answer 3

methyltransferase

S-adenosylmethionine (SAM)

Question 4

One of the most important Phase II reactions?

Answer 4

Glucuronidation

Question 5

What does “Glucuronic acid conjugation” give?

Answer 5

Beta glucuronides

Question 6

Glucuronide conjugates are typically?

Answer 6

Inactive

Question 7

Which glucuronide conjugate is active?

Answer 7

morphine-6-gluronide

Question 8

Enzyme used in Glucuronidation?

Answer 8

glucuronyltransferase

specifically:Uridine diphosphoglucuronyltransferase

Question 9

Coenzyme used in Glucuronidation?

Answer 9

uridine diphosphoglucuronic acid (UDPGA)

Question 10

What does O-glucuroides act on?

Answer 10

Alcohols, phenols, and carboxylic acids

Question 11

N-glucuronides act on?

Answer 11

aromatic amines-acetylation is more important

aliphatic amines-deamination is more important

Question 12

Sulfate Conjugation acts primarily on?

Answer 12

Alcohols and phenols

Question 13

Enzyme and coenzyme for Sulfate Conjugation?

Answer 13

sulfotransferases

3 phosphoadenosine 5 phosphosulfate (PAPS)

Question 14

What is PAPS?

Answer 14

The active sulfate