2.14 Flashcards
Pharmaceutical Aspects
Drug is ready for absorption
“circulatory system”
Pharmacokinetic Aspects
Absorption, Distribution, Biotransformation, Elimination
“What they body does with the drug”
Pharmacodynamic Aspects
Actions to alter cellular-physiological systems
“What the does the drug do?”
Therapeutic Aspects
Responses that provide therapeutic and undesirable (“side effects”) actions
5 Aspects of the Receptor Theory
- Observations of the chemical and physiological specificity
- Genes encoding receptor proteins have been cloned and sequenced based
- Quantitative relationship between drug dose and pharmacologic effect (dose vs concentration (heart invitro))
- Selectivity of drug action
- Pharmacologic agonist and antagonists
There is no receptor in the body that doesnt have a unique chemical in body to react with
Most drugs dont create anything new they alter communication system
What are drug receptors?
- Cell surface or intracellular regulator proteins
- Enzymes
- Structural Proteins
Effect max
Maximum response of system
EC50
Concentration at half the maximum response
Law of Mass Action
Two opposing forces: augmentation or action and inhibition
Clark’s Theory
R + L RL
Ka=?
[RL]/([R][L])
Kd=?
([R][L])/[RL]
What happens to the affinity as Kd increases?
Affinity decreases
