28/02 Flashcards
What cancers are the BRCA2 gene most associated with?
Breast Cancer
Can cause prostate cancer and ovarian cancer also
What is the most common cause of Guillain Barre Syndrome?
Campylobacter jejuni
What is a feature of facial nerve palsy?
Hyperacusis (intolerance to sounds- hearing loud sounds can be painful)
Facial paralysis- difficulty making facial expressions
What are features of hypocalcaemia?
Muscle twitching/cramping/spasm
Perioral paraesthesia
Prolonged QT
Cataracts
Trosseau sign
-cramping of hand during BP being taken- wrist flexion and fingers drawn together
What are causes of hypocalcaemia?
Vit D deficiency CKD Hypoparathyroidism Phenytoin Mg deficiency Late stage rhabdomyolysis
What can be used as prophylaxis of variceal bleeding?
Propanolol
What is the management of SIADH?
Fluid restriction
Vasopressin receptor antagonists- to reduce ADH levels
What is a side effect of metoclopramide in young people?
Acute dystonia- involuntary muscle contractions
What are complications of nephrotic syndrome?
Increased risk of VTE Increased risk of infections CV complications Anaemia Acute renal failure Hypovolaemic crises
How is a restrictive picture shown in spirometry?
Normal or increased FEV1:FVC
FVC massively decreased
FEV1 normal or decreased
What are causes of restrictive lung disease?
Neuromuscular disorders
Pulmonary fibrosis
Acute respiratory distress syndrome
Obesity
What are causes of obstructive lung disease?
Asthma
COPD
Bronchiectasis
