261 - Intro to Neoplasia Flashcards
What is the difference between grade 3, grade 4, and grade 5 prostate adenocarcinoma?
- 3 - sheets of donuts, all are still distinct
- 4 - donuts coalesce together
- 5 - cells in sheets, not even trying to form glands
List 2 tumor mutations in a colon tumor that predict a poor response to anti-EGFR therapy
- BRAF V600E
- KRAS mutation
Microsatillite instablity (mutation in DNA mismatch repair genes) predicts a poor response to which chemotherapy agent?
5-FU
In colon carcinoma, what histologic feature is most important in tumor staging?
Depth of invasion
Tumor stage depends on depth
Expression of what protein is notably absent in lobular carcinoma?
E-cadherin
Cells will be in sigle file rows
What is the most common subtype of breast cancer?
Invasive ductal carcionma
In which organ is tumor size most relevant to staging?
- Breast
- Colon
- Prostate
a. Breast
Which type of colon polyp harbors risk of malignant transformation?
Tubular adenoma
Hyperplastic polyps have no risk
What is the most important prognostic factor for a breast tumor?
Tumor size
Which type of breast cancer carries a higher risk of bilateral disease?
Lobular carcinoma (invasive and in-situ)
The majority of prostate cancers arise in which zone of the prostate gland?
Peripheral zone