261 - Intro to Neoplasia Flashcards

1
Q

What is the difference between grade 3, grade 4, and grade 5 prostate adenocarcinoma?

A
  • 3 - sheets of donuts, all are still distinct
  • 4 - donuts coalesce together
  • 5 - cells in sheets, not even trying to form glands
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

List 2 tumor mutations in a colon tumor that predict a poor response to anti-EGFR therapy

A
  • BRAF V600E
  • KRAS mutation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Microsatillite instablity (mutation in DNA mismatch repair genes) predicts a poor response to which chemotherapy agent?

A

5-FU

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

In colon carcinoma, what histologic feature is most important in tumor staging?

A

Depth of invasion

Tumor stage depends on depth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Expression of what protein is notably absent in lobular carcinoma?

A

E-cadherin

Cells will be in sigle file rows

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the most common subtype of breast cancer?

A

Invasive ductal carcionma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

In which organ is tumor size most relevant to staging?

  1. Breast
  2. Colon
  3. Prostate
A

a. Breast

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which type of colon polyp harbors risk of malignant transformation?

A

Tubular adenoma

Hyperplastic polyps have no risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the most important prognostic factor for a breast tumor?

A

Tumor size

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which type of breast cancer carries a higher risk of bilateral disease?

A

Lobular carcinoma (invasive and in-situ)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The majority of prostate cancers arise in which zone of the prostate gland?

A

Peripheral zone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly