260: Intro to Heme Malignancies Flashcards
All ___ cells are CD3+
All T cells are CD3+
What markers are present on all NK cells? (2)
CD56+ and CD16+
What kind of cell is this?
Monocyte
From the myeloid lineage
Differentiates into macrophages, dendritic cells
What kind of cell is this?
Neutrophil
From common myeloid progenitor
Multi-lobed; shoul have 4, more lobes is concerning
What is the difference beween lymphoma and leukemia?
Lymphoma = tissue based, derived from lymphoid cells (B and T)
Leukemia = in bone marrow, can have myeloid or lymphoid origin
But there is ambiguity. No strict criteria.
All ____ cells are CD19+
All B cells are CD19+
What is the major difference between myelodysplastic and myeloproliferative neoplasms?
It’s all in the name!
Myelodysplastic = dysplasia (will see decreased peripheral counts)
Myeloproliferative = elevated blood counts
List 5 white blood cell progeny of the common myeloid progenitor
- Neutrophils
- Eosinophils
- Basophils
- Mast cells
- Antigen-presenting cells (monocytes)
RBCs and platlets also derived from the common myeloid progenitor, but are not WBCs
The diagnosis of acute leukemia requires ___% blasts in the peripheral blood or bone marrow
The diagnosis of acute leukemia requires 20% blasts in the peripheral blood or bone marrow
Even if the peripheral blood looks fine, do a bone marrow biopsy - sometimes the blasts just hang out here, and it’s still leukemia
What kind of cell is this?
Lymphocyte
I think T cells and B cells look about the same
What kind of cell is this?
Basophil
What kind of cell is this?
Eosinophil
Eosiniphilic (red) cytoplasm
List 4 progeny of the common lymphoid progenitor
- NK cells
- T cells
- B cells
- Plasma cells (differntiated B cells)
