2.5 Examples of Systemic autoimmune diseases

Question 1

What is a feature of systemic AI disease?

Answer 1

IgG auto-antibodies form against cellular components

Question 2

What ECM component do IgG AA’s form against in systemic AI disease?

Answer 2

Collagen

Question 3

What cell surface proteins do IgG AA’s form against in systemic AI disease?

Answer 3

HLA antigens

Question 4

What cytoplasmic proteins do IgG AA’s form against in systemic AI disease?

Answer 4

Actin,Myelin

Question 5

What nuclear components do IgG AA’s form against in systemic AI disease?

Answer 5

Histone proteins. DNA

Question 6

What occurs in SAID after periods of intense inflammation?

Answer 6

Remission (relative calm)

Question 7

3 examples of SAID?

Answer 7

Lupus, MS, Rheumatoid arthritis

Question 8

Which conditions do Ectopic Lymphoid Tissues form?

Answer 8

MS and Rheumatoid arthritis

Question 9

Which conditions do Ectopic Lymphoid Tissues form?

Answer 9

MS and Rheumatoid arthritis

Question 10

What forms immune complexes in SAIDs?

Answer 10

Form when IgM IgG and IgA AA bind to Fc region of human IgG

Question 11

What is the AA target in Poly/Dermatomyositis?

Answer 11

Nuclear. DNA. tRNA synthetases

Question 12

What is the AA target in Rheumatoid Arthritis?

Answer 12

Citrullinated proteins and complexes.

Question 13

What does ‘citrullinated’ mean?

Answer 13

Conversion of arginine to citrulline.

Question 14

What is the AA target in MS?

Answer 14

Myelin Sheath

Question 15

What is the AA target in Systemic Lupus ?

Answer 15

DNA, Nuclear protein and complexes.

Question 16

What is the AA target in Sjogrens syndrome?

Answer 16

Nuclear protein and complexes

Question 17

What is Dermatomyositis?

Answer 17

Profound muscle weakness that is symmetrical

Question 18

How rare is Dermatomyositis?

Answer 18

6-7 out of 100,000

Question 19

What is Dermatomyositis Perifascicular atrophy?

Answer 19

Small muscle fibres occur at periphery of fascicle

Question 20

What is a KEY CHARACTERISTIC of Dermatomyositis?

Answer 20

T-cell infiltration into muscles

Question 21

What happens to the skin n Dermatomyositis?

Answer 21

Heliotrope rash and Gottrons papules

Question 22

Which muscles weaken in Dermatomyositis?

Answer 22

Proximal muscles

Question 23

Which areas are affected by Rheumatoid Arthritis?

Answer 23

Joints of wrists, hands, elbows, shoulders, knees and ankles SYMETRICALLY.

Question 24

Which joints become inflamed in RA?

Answer 24

Synovial membranes (synovium) of joints. Excess fluid product accumulates in joints.

Question 25

What happens physically to bones/joints in RA?

Answer 25

Cartilage is rough/pitted and bones erode.

Question 26

What is destroyed in MS?

Answer 26

Myelin sheath

Question 27

Symptoms of MS?

Answer 27

Brain and spinal lesions. Sensory disturbances. Visual disturbance. Muscle control loss. Relapse/remittance/secondary.

Question 28

What are symptoms of Lupus?

Answer 28

Wide range of symptoms and affected organs. Fatigue, pain in muscles/joints, weakness.

Question 29

What do nuclear antibodies attack in lupus?

Answer 29

Target chromatin.

Question 30

What is PRIMARY symptom of Sjogrens syndrome?

Answer 30

Dry mouth and eye

Question 31

What organs may be impacted in Sjogrens syndrome?

Answer 31

Muscles/Kidneys/Lungs

Question 32

What do immune cells target in Sjogrens?

Answer 32

Glands (salivary)