2.5 Examples of Systemic autoimmune diseases Flashcards
What is a feature of systemic AI disease?
IgG auto-antibodies form against cellular components
What ECM component do IgG AA’s form against in systemic AI disease?
Collagen
What cell surface proteins do IgG AA’s form against in systemic AI disease?
HLA antigens
What cytoplasmic proteins do IgG AA’s form against in systemic AI disease?
Actin,Myelin
What nuclear components do IgG AA’s form against in systemic AI disease?
Histone proteins. DNA
What occurs in SAID after periods of intense inflammation?
Remission (relative calm)
3 examples of SAID?
Lupus, MS, Rheumatoid arthritis
Which conditions do Ectopic Lymphoid Tissues form?
MS and Rheumatoid arthritis
Which conditions do Ectopic Lymphoid Tissues form?
MS and Rheumatoid arthritis
What forms immune complexes in SAIDs?
Form when IgM IgG and IgA AA bind to Fc region of human IgG
What is the AA target in Poly/Dermatomyositis?
Nuclear. DNA. tRNA synthetases
What is the AA target in Rheumatoid Arthritis?
Citrullinated proteins and complexes.
What does ‘citrullinated’ mean?
Conversion of arginine to citrulline.
What is the AA target in MS?
Myelin Sheath
What is the AA target in Systemic Lupus ?
DNA, Nuclear protein and complexes.
What is the AA target in Sjogrens syndrome?
Nuclear protein and complexes
What is Dermatomyositis?
Profound muscle weakness that is symmetrical
How rare is Dermatomyositis?
6-7 out of 100,000
What is Dermatomyositis Perifascicular atrophy?
Small muscle fibres occur at periphery of fascicle
What is a KEY CHARACTERISTIC of Dermatomyositis?
T-cell infiltration into muscles
What happens to the skin n Dermatomyositis?
Heliotrope rash and Gottrons papules
Which muscles weaken in Dermatomyositis?
Proximal muscles
Which areas are affected by Rheumatoid Arthritis?
Joints of wrists, hands, elbows, shoulders, knees and ankles SYMETRICALLY.
Which joints become inflamed in RA?
Synovial membranes (synovium) of joints. Excess fluid product accumulates in joints.
What happens physically to bones/joints in RA?
Cartilage is rough/pitted and bones erode.
What is destroyed in MS?
Myelin sheath
Symptoms of MS?
Brain and spinal lesions. Sensory disturbances. Visual disturbance. Muscle control loss. Relapse/remittance/secondary.
What are symptoms of Lupus?
Wide range of symptoms and affected organs. Fatigue, pain in muscles/joints, weakness.
What do nuclear antibodies attack in lupus?
Target chromatin.
What is PRIMARY symptom of Sjogrens syndrome?
Dry mouth and eye
What organs may be impacted in Sjogrens syndrome?
Muscles/Kidneys/Lungs
What do immune cells target in Sjogrens?
Glands (salivary)
