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Autoimmune > 1:Terms and Intro > Flashcards

1:Terms and Intro Flashcards

1
Q

Define Auto Immunity

A

An immune response of Ab against Self Ag

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2
Q

What immunity is a humoral or cell mediated response against components of own cells/tissues?

A

Auto Immunity

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3
Q

What is an auto antibody?

A

An altered cell (auto antigen) that elicits production of antibodys

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4
Q

What is an Auto or Self-antigen?

A

Antigens present in a person’s own cells.

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5
Q

What antigens are altered by actions of bacteria, viruses , chemical or drugs?

A

Auto or Self-antigens

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6
Q

What is an autoimmune disease?

A

A group of disorders caused by tissue injury from humoral or cell mediated immune response to self -antigens.

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7
Q

What causes a humoral immune response to self antigens?

A

Auto - antibodies

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8
Q

What causes a cell-mediated immune response to self-antigens?

A

Auto-reactive T cells.

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9
Q

Do autoimmune responses involve the innate or adaptive immunity?

A

Adaptive

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10
Q

What is specific about the adaptive immune response?

A

Highly specific pathogen mediated process. Distinguishes between self and non-self.

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11
Q

What is developed after an adaptive immune response?

A

Immunological memory

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12
Q

Lost the causes of autoimmune disease:

A

. Sequestered or Hidden antigens
.Neo antigens
.Molecular Mimicry
.Loss of immunoregulation

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13
Q

Define a sequestered or Hidden antigen?

A

Antigens in secluded places that are not accessible to immune system.

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14
Q

What is an example of sequestered antigens?

A

Lens antigen, Sperms antigen and Thyroglobulin

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15
Q

Define a neo antigen?

A

Altered or modified antigens

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16
Q

How are neo antigens altered or modified?

A

Physically -Irridation
Chemical- Drugs
Microbial Agents- Intracellular Viruses

17
Q

What is molecular Mimicry?

A

When a foreign antigen resembles itself.

18
Q

What antigens do many species share?

A

Organ specific antigens

19
Q

What is loss of immunoregulation?

A

A loss of self-tolerance

20
Q

What causes loss of immunoregulation?

A

Over activity or lowered activity of T and B Cells

21
Q

What percentage of women have thyroid disease?

A

Over 3%

22
Q

How many people from general population have Rheumatoid arthritis?

A

1%

23
Q

How many adult women are affected by Primary Sjögrens syndrome?

A

0.6-3%

24
Q

How much of general population have Systemic lupus erythematosus?

A

0.12%

25
Q

How much of general population have MS?

A

0.1%

26
Q

How many children have T1 Diabetes?

A

0.1%

27
Q

How many middle aged and elderly women have Primary Biliary cirrhosis?

A

0.05-0.1%

28
Q

How much population have Myasthenia gravis?

A

0.01%

Autoimmune (4 decks)

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