1:Terms and Intro Flashcards
Define Auto Immunity
An immune response of Ab against Self Ag
What immunity is a humoral or cell mediated response against components of own cells/tissues?
Auto Immunity
What is an auto antibody?
An altered cell (auto antigen) that elicits production of antibodys
What is an Auto or Self-antigen?
Antigens present in a person’s own cells.
What antigens are altered by actions of bacteria, viruses , chemical or drugs?
Auto or Self-antigens
What is an autoimmune disease?
A group of disorders caused by tissue injury from humoral or cell mediated immune response to self -antigens.
What causes a humoral immune response to self antigens?
Auto - antibodies
What causes a cell-mediated immune response to self-antigens?
Auto-reactive T cells.
Do autoimmune responses involve the innate or adaptive immunity?
Adaptive
What is specific about the adaptive immune response?
Highly specific pathogen mediated process. Distinguishes between self and non-self.
What is developed after an adaptive immune response?
Immunological memory
Lost the causes of autoimmune disease:
. Sequestered or Hidden antigens
.Neo antigens
.Molecular Mimicry
.Loss of immunoregulation
Define a sequestered or Hidden antigen?
Antigens in secluded places that are not accessible to immune system.
What is an example of sequestered antigens?
Lens antigen, Sperms antigen and Thyroglobulin
Define a neo antigen?
Altered or modified antigens
How are neo antigens altered or modified?
Physically -Irridation
Chemical- Drugs
Microbial Agents- Intracellular Viruses
What is molecular Mimicry?
When a foreign antigen resembles itself.
What antigens do many species share?
Organ specific antigens
What is loss of immunoregulation?
A loss of self-tolerance
What causes loss of immunoregulation?
Over activity or lowered activity of T and B Cells
What percentage of women have thyroid disease?
Over 3%
How many people from general population have Rheumatoid arthritis?
1%
How many adult women are affected by Primary Sjögrens syndrome?
0.6-3%
How much of general population have Systemic lupus erythematosus?
0.12%
How much of general population have MS?
0.1%
How many children have T1 Diabetes?
0.1%
How many middle aged and elderly women have Primary Biliary cirrhosis?
0.05-0.1%
How much population have Myasthenia gravis?
0.01%
