244- tumor immunology

Question 1

what t cells tend to be good and bad in cancer?

Answer 1

Good: CD8 and Th1
Bad: Th2, Th17, Treg

Question 2

what t cells tend to be good and bad in cancer?

Answer 2

Good: CD8 and Th1
Bad: Th2, Th17, Treg

Question 3

three phases of immunoediting

Answer 3

Elimination (innate and adaptive)
Equilibrium (adaptive only, can persist for life)
Escape (circumventing recognition)

Question 4

what is an anti-apoptotic molecule that gets upgraded in cancer? A pro-apoptotic molecule that gets down regulated?

Answer 4

Bcl-2

Fas

Question 5

What are CTLA-4 and PD-1 antibodies used for?

Answer 5

they block the CTLA-4 and PD-1 ligands on CD8 and CD4 T-cells so they can’t react with the APC. They normally cause immunosuppression.

Question 6

What are CAR T-cells?

Answer 6

You collect T-cells then genetically engineer them to produce special receptors called Chimeric Antigen Receptors which allow the T cell to recognize a specific antigen on a tumor cell.. They’re grown in lab then injected

Question 7

three phases of immunoediting

Answer 7

Elimination (innate and adaptive)
Equilibrium (adaptive only, can persist for life)
Escape (circumventing recognition)

Question 8

what is an anti-apoptotic molecule that gets upgraded in cancer? A pro-apoptotic molecule that gets down regulated?

Answer 8

Bcl-2

Fas

Question 9

What are CTLA-4 and PD-1 antibodies used for?

Answer 9

they block the CTLA-4 and PD-1 ligands on CD8 and CD4 T-cells so they can’t react with the APC. They normally cause immunosuppression.

Question 10

What are CAR T-cells?

Answer 10

You collect T-cells then genetically engineer them to produce special receptors called Chimeric Antigen Receptors which allow the T cell to recognize a specific antigen on a tumor cell.. They’re grown in lab then injected