23.6.2013(46) Flashcards

0
Q

Boundaries of anatomical snuff box

A

Abductor pollicis longus,extensor pollicis brevis(anterior)
Extensor pollicis longus(posterior)
Radial styloid,scaphoid,trapezium,base of first MC(base)

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1
Q

Contents of anatomical snuff box

A

Cephalic vein
Superficial Br.radial nerve
Radial artery

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2
Q

Parietal cell is predominantly seen in which part of gastric gland

A

Neck

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3
Q

Parietal cells are found in

A

Fundus and BODY(parietal cells)

Chief cells are also found here(cardia)

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4
Q

Key executive role in sleep regulation is played by

A

Ventrolateral preoptic area

For awake state-posterior hypothalamus

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5
Q

Hexokinase belongs to class of

A

Transferase

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6
Q

Substances that prevent premature reanneling of DNA strands

A

Single strand binding proteins

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7
Q

Myocardial oxygen demand depends on

A

Intra myocardial tension
Inotropy
Chronotropy
Mean arterial pressure

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8
Q

Primase in E.coli

A

DnaG

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9
Q

Leading strand synthesis in eukaryotes

A

Epsilon

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10
Q

Lagging strand synthesis in eukaryotes

A

Delta

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11
Q

Proof reading in eukaryotes

A

Beta

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12
Q

Primase in eukaryotes

A

Alpha

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13
Q

Mitochondrial DNA synthesis in eukaryotes

A

Gamma

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14
Q

Processive enzymes in eukaryotic DNA synthesis

A

Epsilon

Delta

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15
Q

Transition from G2-M

A

Cyclin B

Cdk1

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16
Q

Synthesis of DNA in early S phase

A

Cyclin E and A

Cdk 2

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17
Q

Transition of G1-S checkpoint

A

Cyclin D

Cdk 4 and 6

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18
Q

Human to human transmission does not occur in

A

Leptospirosis

Legionella

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19
Q

Very stable RNA

A

t-RNA
r-RNA
sn-RNA

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20
Q

Unstable RNA

A

m-RNA

microRNA is stable

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21
Q

RNA polymerase 1 synthesises

A

r-RNA

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22
Q

RNA polymerase 2 synthesises

A

m-RNA
sn-RNA
micro-RNA

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23
Q

RNA polymerase 3 synthesises

A

t-RNA

5S-RNA

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24
Q

Sensitivity of RNA polymerases to alpha amanitin

A

Insensitive 1
Highly sensitive 2
Intermediate sensitivity 3

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25
Q

Hemorrhagic manifestation in Weil disease is commonly seen in

A

Lungs

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26
Q

Jaundice in Weil disease is

A

Bile plugging

Not due to hepatocellular damage

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27
Q

Electrolyte abnormalities in Weil disease

A

Hypomagnesimia

Hypokalemia

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28
Q

Partial deficiency of HGPRTase

A

Kelley-seegmiller syndrome

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29
Q

Difference btw Kelley seegmiller

A

No Dystonia
Normal intelligence
No compulsive self injurious behaviour
In Kelley-seegmiller

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30
Q

Rx of severe leptospirosis

A
1.I.V penicillin
Ampicillin
Amoxicillin
Ceftriaxone 
Cefotaxime
Erythromycin
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31
Q

Effect of oestrogen on lipids

A

Reduce LDL
Increase HDL
Increase triglycerides

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32
Q

Ocular side effect of tamoxifen

A

Retinal deposits

Cataract

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33
Q

Nephrin and podocin chromosomes

A

Podocin chr1

Nephrin chr19

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34
Q

Immediate postoperative complication of any “stoma”

A

Necrosis

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35
Q

Primary error in development

A

Malformation(intrinsic causes)

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36
Q

Secondary errors in development

A

Disruption(previously normal structure getting destroyed due to external factor)
Deformation(external compression)

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37
Q

Conditions with decreased LAP score

A

PNH

CML

38
Q

Conditions with increased LAP scores

A

Polycythemia
Leukomoid reaction
Infection

39
Q

Site of insulinoma

A

Equally distributed in pancreas

40
Q

Site of Glucagonoma

A

Tail and body(VIPoma)

41
Q

Site of Somatostatinoma

A

Head
Isthmus
Duodenopancreatic groove

42
Q

Most prevalent HCV genotype

A
Genotype 1
Genotype 3(India)
43
Q

Genotype of HCV resistant to Interferon

A

Genotype 1

44
Q

Criteria for evaluating strength of association between cause and effect

A

Bradford hill

45
Q

Multiple heart sounds are classical of

A

Ebstein anomaly

46
Q

Selenium is risk factor for

A

Lung and nasal carcinoma

47
Q

Indications for lumbar sympathectomy

A

1.hyperhydrosis
1.causalgia
PVD
beurger
Acrocyanosis/erythrocyanosis
Raynaud
Frost bite

48
Q

Best graft for infra inguinal occlusive disease

A

Great Saphenous vein

Suprainguinal PTFE

49
Q

Indication for repair in asymptomatic aortic aneurysm

A

Size greater than or equal to 55mm(men),greater than 45mm(women)
Rate of expansion is greater than 1cm per year

50
Q

Most common fetal response to hypoxia

A

Bradycardia

51
Q

Types of Von wilibrand disease

A

Type 1 quantitative defect (AD)
Type 2 qualitative defect(AR/AD)
Type 3 complete absence(AR)

52
Q

Angiostatic factors

A
Angiostatin
Endostatin
Thrombospondin
Pigment epithelium derived factor
INF A
Platelet factor 4
53
Q

MMP inhibitor

A

Doxycycline

54
Q

Medical Rx of aortic aneurysm

A

NSAID

doxycycline

55
Q

Most common type of Von wilibrand disease

A

Type 1

56
Q

Most common neurological manifestation of incontinentia pigmenti

A

Seizures

57
Q

Stages of incontinentia pigmenti

A

Linear vesicular
Verrucous
Hyperpigmented
Hypopigmented/atrophic

58
Q

vWD associated with thrombocytopenia

A

Type 2B

59
Q

Signs of successful stellate ganglion block

A

Horner
Flushing of face/conjunctival injection
Lacrimation(if superior cervical ganglion is involved)
Injection of ear drum(muller syndrome)
Stuffy nose(guttman sign) ipsilateral nose block
Increased temperature of face and upper extremity on ipsilateral side
Ventilation in ipsilateral extremity

60
Q

Diff btw infiltrating gall bladder carcinoma and adenoma

A

Focal or generalised thickening of the GB with comet tail artifacts
Hypertrophied rokitanski Aschoff sinuses

61
Q

Kommerell diverticulum

A

Aneurysm at the origin of abnormal rt subclavian artery

Causes dysphagia lusoria

62
Q

Characteristic feature of contrast CT in adrenal adenoma

A

Rapid uptake and rapid washout of contrast

63
Q

Vascular occlusion,bypass is done in

A

Aortic arch

64
Q

Vascular occlusion,PTA/stenting

A

Distal abdominal aorta

Iliac arteries

65
Q

Vascular occlusion,end arterectomy

A

Carotid bifurcation

66
Q

Transluminal angioplasty is best in

A

High flow

Large calibre

67
Q

vWF is high in

A
It's an acute phase reactant
Stress
Oestrogen
Pregnancy
Neoplasm 
Thyrotoxicosis
68
Q

vWF is low in which blood group

A

Group O

69
Q

Tuberculids

A

Hypersensitivity reaction to tubercular proteins

70
Q

vWF activity is measured as

A

Ristocetin cofactor activity

Collagen binding activity

71
Q

Diff btw vWD 2A and 2M

A

Qualitative defect with absent HMW multimers in 2A

72
Q

Persons with disability act,diseases covered

A
-Blindness
 Total absence of sight
  6/60 vision in better eye after correction
 Field of vision 20 degree or less
-low vision
-cured/uncured leprosy
-hearing impairment
  Loss of 60db or more in better ear
-locomotor disability
-MR
-cerebral palsy
-Mental illness
73
Q

Minimum percentage of disability that must be present to avail disability benefits

A

40%

74
Q

Test used to detect VWD type 2B

A

RIPA is increased

ristocetin induced platelet agglutination

75
Q

Best vascular graft for extra-anatomic bypass

A

PTFE

76
Q

Cause of increased RIPA in VWD 2B

A

High affinity vWF which causes thrombocytopenia and decreased circulating VWF

77
Q

VWD 2N

A

Factor VIII carrying activity of vWF is reduced

78
Q

Acquired haemophilia

A

VWD 2N

79
Q

Genetic screening marker for aggressive form of papillary carcinoma of thyroid in young

A

ret/PTC3

80
Q

Desmopressin should be avoided in which VWD

A

Type 2B

Most useful in type 1

81
Q

Giant panda sign is seen in

A

Wilson

82
Q

Radio pharmaceutical used for assessing myocardial perfusion

A

Thallium 201

83
Q

Signs of pulmonary embolism

A

Palla
McConnell
Westermark

84
Q

Non caseous granuloma is seen in which TB lesion

A

Lichen scrofulosrum

85
Q

Radiation dose associated with mammography

A

Less than 0.2 rads or cGY

86
Q

Breast within breast appearance is seen in

A

Hamartoma of breast

87
Q

Cutaneous tuberculosis

A
Exogenous
  Primary inoculation tuberculosis 
    Tuberculous chancre(occurs in individual not previously exposed to TB)
     Tuberculosis verrucosa cutis(occurs in sensitised individuals)
Endogenous
  Scrofuloderma
  Lupus vulgaris
  Metastatic tuberculous abscess
  Acute Milliary TB
  Orificial TB
TB due to BCG immunisation
88
Q

Tuberculid reactions

A

Lichen scrofulosorum
Papulonecrotic tuberculid
Erythema induratum

89
Q

Incontinentia pigmenti in males?

A

Klinfelter

90
Q

Cutaneous manifestations in incontinentia pigmenti appear

A

At birth or Within 2 weeks of birth

91
Q

Autosomal recessive VWD

A

Type 3

Type 2N

92
Q

HMW multimers are low in

A

2B
2A
3