23.3 NS: Learning and memory

Question 1

What did they do to HM?

What happened to his memory?

Answer 1

Resection of medial temporal lobe

Severe retrograde amnesia

Question 2

What did HM demonstrate on the mirror reversal task?

Answer 2

Implicit learning, he had no recollection of undertaking the task but showed signs of improvement

Question 3

What are the types of memory?

Answer 3

Declarative (explicit)

Nondeclarative (implicit)

Question 4

Where are memories stored?

Answer 4

Hippocampus in medial temporal lobe

Question 5

What is the NMDA receptor?

Answer 5

A glutamate receptor that has a role in memory

Question 6

What happens if we put a mutant (NR1 of the NMDA R’) mouse in the Morris water maze?

Answer 6

It has a memory deficit and can’t remember where the hidden platform is

Question 7

What is the ‘Doogie’ mouse? What does it show?

Answer 7

Mouse that has increased N2RB expression, shows cognitive enhancement

Question 8

What does LTP refer to?

Answer 8

Synaptic plasticity